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Research Lab Results for imaging

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  • J. Webster Stayman Lab

    Lab Website

    The J. Webster Stayman Lab studies both emission tomography and transmission tomography (CT, to...mosynthesis and cone-beam CT). Our research activities relate to 3-D reconstruction, including model-based statistical / iterative reconstruction, regularization methods and modeling of imaging systems. We are developing a generalized framework for penalized likelihood (PL) reconstruction combining statistical models of noise and image formation with incorporation of prior information, including patient-specific prior images, atlases and models of components / devices known to be in the field of view. Our research includes algorithm development and physical experimentation for imaging system design and optimization. view more

    Research Areas: 3-D, imaging, emission tomography, transmission tomography, radiology, computed tomography
  • James Pekar Lab

    Lab Website

    How do we see, hear, and think? More specifically, how can we study living people to understand... how the brain sees, hears, and thinks? Recently, magnetic resonance imaging (MRI), a powerful anatomical imaging technique widely used for clinical diagnosis, was further developed into a tool for probing brain function. By sensitizing magnetic resonance images to the changes in blood oxygenation that occur when regions of the brain are highly active, we can make "movies" that reveal the brain at work. Dr. Pekar works on the development and application of this MRI technology.

    Dr. Pekar is a biophysicist who uses a variety of magnetic resonance techniques to study brain physiology and function. Dr. Pekar serves as Manager of the F.M. Kirby Research Center for Functional Brain Imaging, a research resource where imaging scientists and neuroscientists collaborate to study brain function using unique state-of-the-art techniques in a safe comfortable environment, to further develop such techniques, and to provide training and education. Dr. Pekar works with center staff to serve the center's users and to keep the center on the leading edge of technology.
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    Research Areas: magnetic resonance, functional magnetic resonance imaging, radiology
  • Janet Record Lab

    Principal Investigator:
    Janet Record, M.D.
    Medicine

    Research in the Janet Record Lab focuses on medical education and patient-centered care. We’re ...currently developing a curriculum for internal medicine residents in the inpatient general medicine service setting. The curriculum teaches residents to use hand-carried ultrasound for imaging the inferior vena cava to assess volume status. view more

    Research Areas: medical education, patient-centered health care, imaging, internal medicine, inferior vena cava
  • Jeff Bulte Lab

    The clinical development of novel immune and stem cell therapies calls for suitable methods tha...t can follow the fate of cells non-invasively in humans at high resolution. The Bulte Lab has pioneered methods to label cells magnetically (using tiny superparamagnetic iron oxide nanoparticles) in order to make them visible by MR imaging.

    While the lab is doing basic bench-type research, there is a strong interaction with the clinical interventional radiology and oncology groups in order to bring the methodologies into the clinic.
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    Research Areas: immunology, stem cells, cancer, MRI, interventional radiology
  • Jinyuan Zhou Lab

    Lab Website

    Dr. Zhou's research focuses on developing new in vivo MRI and MRS methodologies to study brain ...function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, high-resolution diffusion tensor imaging (DTI), magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, and tissue protein MR imaging. Notably, Dr. Zhou and his colleagues invented the amide proton transfer (APT) approach for brain pH imaging and tumor protein imaging. His initial paper on brain pH imaging was published in Nature Medicine in 2003 and his most recent paper on tumor treatment effects was published in Nature Medicine in 2011. A major part of his current research is the pre-clinical and clinical imaging of brain tumors, strokes, and other neurologic disorders using the APT and other novel MRI techniques. The overall goal is to achieve the MRI contrast at the protein and peptide level without injection of exogenous agents and improve the diagnostic capability of MRI and the patient outcomes. view more

    Research Areas: magnetic resonance, functional magnetic resonance imaging, brain, stroke
  • Jon Russell Lab

    The Jon Russell lab focuses on thyroid and parathyroid pathology as well as improving patient s...afety and education using healthcare technology. Additional focuses include utilizing new technology to advance on the techniques of minimally invasive neck surgery. Current and previous efforts include the development of mobile and web-based applications to educate physicians and patients, utilizing ultrasound for vocal cord imaging, understanding the nuances of advanced thyroid cancer, and exploring the role of scarless thyroid surgery in a North American population. view more

    Research Areas: patient satisfaction, thyroid cancer, perioperative information delivery, health outcomes, otolaryngology, postoperative care, endocrinology
  • Jun Hua Lab

    Lab Website

    Dr. Hua's research has centered on the development of novel MRI technologies for in vivo functi...onal and physiological imaging in the brain, and the application of such methods for studies in healthy and diseased brains. These include the development of human and animal MRI methods to measure functional brain activities, cerebral perfusion and oxygen metabolism at high (3 Tesla) and ultra-high (7 Tesla and above) magnetic fields. He is particularly interested in novel MRI approaches to image small blood and lymphatic vessels in the brain. Collaborating with clinical investigators, these techniques have been applied 1) to detect functional, vascular and metabolic abnormalities in the brain in neurodegenerative diseases such as Huntingdon's disease (HD), Parkinson's disease (PD), Alzheimer's disease (AD) and mental disorders such as schizophrenia; and 2) to map brain functions and cerebrovascular reactivity for presurgical planning in patients with vascular malformations, brain tumors and epilepsy. view more

    Research Areas: imaging technology development, applications in brain diseases
  • Karakousis Lab

    Lab Website
    Principal Investigator:
    Petros Karakousis, M.D.
    Medicine

    The Karakousis Lab is primarily focused on understanding the molecular basis of Mycobacterium t...uberculosis persistence and antibiotic tolerance. A systems biology-based approach, including the use of several novel in vitro and animal models, in combination with transcriptional, proteomic, genetic, imaging, and computational techniques, is being used to identify host cytokine networks responsible for immunological control of M. tuberculosis growth, as well as M. tuberculosis regulatory and metabolic pathways required for bacillary growth restriction and reactivation. In particular, we are actively investigating the regulatory cascade involved in the mycobacterial stringent response. Another major focus of the lab is the development of host-directed therapies for TB, with the goal of shortening treatment and improving long-term lung function. Additional research interests include the development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB disease, and for the detection of drug resistance. view more

    Research Areas: diagnostics, persistence, infectious disease, Mycobacterium tuberculosis, host-directed therapy, latency, drugs, antibiotics, tuberculosis
  • Kashani Lab

    Lab Website
    Principal Investigator:
    Amir Kashani, M.D., Ph.D.
    Ophthalmology

    Dr. Amir Kashani and his team are developing novel diagnostic and therapeutic methods to diagno...se and treat retinal diseases using advanced imaging methods. These methods can detect the earliest changes in retinal capillaries before they are noticeable to the patient or doctor. view more

    Research Areas: Retinal Vascular Disease, OCT Angiography, Vascular Cognitive Impairment and Dementia, diabetic retinopathy, Stem Cell Therapy of Retinal Disease
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