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Displaying 1 to 10 of 14 results for hypoxia

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  • Charles Wiener Lab

    The Charles Wiener Lab primarily conducts research on pulmonary circulation and hypoxia as well as respiratory muscle function in patients with neuromuscular diseases. Our recent studies have included investigating the treatment of pericardial effusions in patients with pulmonary arterial hypertension and examining the use of non-invasive ventilation in patients with amyotrophic lateral sclerosis (ALS). We also have an interest in medical education research. Our work in this area has included reviewing the role of academic medical centers in emerging health care markets.

    Research Areas: respiratory system, neuromuscular diseases, ALS, pulmonary medicine, hypertension, hypoxia

    Principal Investigator

    Charles Wiener, M.D.

    Department

    Medicine

  • Gilkes Lab

    Our lab is focused on determining the role of hypoxia in breast cancer metastasis. We are particularly interested in the changes in the extracellular matrix that occur under hypoxic conditions and promote cancer cell migration.

    Research Areas: breast cancer, HIF-1, hypoxia, ECM

    Principal Investigator

    Daniele Gilkes, Ph.D.

    Department

    Oncology

  • Gregg Semenza Lab

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned and characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.

    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia

    Principal Investigator

    Gregg Semenza, M.D., Ph.D.

    Department

    Pediatrics

  • Jonathan Jun Lab

    The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

    Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

    Lab Website

    Principal Investigator

    Jonathan Jun, M.D.

    Department

    Medicine

  • Kristine Glunde Lab

    The Glunde lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The lab is developing mass spectrometry imaging as part of multimodal molecular imaging workflows to image and elucidate hypoxia-driven signaling pathways in breast cancer. They are working to further unravel the molecular basis of the aberrant choline phospholipid metabolism in cancer. The Glunde lab is developing novel optical imaging agents for multi-scale molecular imaging of lysosomes in breast tumors and discovering structural changes in Collagen I matrices and their role in breast cancer and metastasis.

    Research Areas: breast cancer, mass spectrometry, imaging, cancer, metastasis, metabolism, optical imaging

  • Larissa Shimoda Lab

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and critical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodeling in patients with pulmonary hypertension.

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia

    Principal Investigator

    Larissa Shimoda, M.S., Ph.D.

    Department

    Medicine

  • Mahendra Damarla Lab

    Work in the Mahendra Damarla Lab focuses primarily on the field of vascular biology. Much of our research involves exploring alternatives to mechanical ventilation as a therapy for acute lung injury. We investigate mitogen-activated protein kinase-activated protein kinase 2 as a method to mediate apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. We have also conducted research on the prevalence of confirmatory tests in patients hospitalized with congestive heart failure or chronic obstructive pulmonary disease (COPD).

    Research Areas: critical care medicine, acute lung injury, lung disease, COPD, vascular biology, hypoxia

    Principal Investigator

    Mahendra Damarla, M.D.

    Department

    Medicine

  • Marie-France Penet Lab

    The Penet lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The lab research focuses on using multimodal imaging techniques to better understand the microenvironment and improve cancer early detection, especially in ovarian cancer. By combining MRI, MRS and optical imaging, we are studying the tumor microenvironment to understand the role of hypoxia, tumor vascularization, macromolecular transport and tumor metabolism in tumor progression, metastasis and ascites formation in orthotopic models of cancer. We also are studying the role of tumor-associated macrophages in tumor progression.

    Research Areas: tumor vascularization, prostate cancer, tumor metabolism, magnetic resonance spectroscopy, macromolecular transport, optical imaging, pancreatic cancer, MRI, tumor-associated macrophages, hypoxia, ovarian cancer, cancer-induced cachexia, cancer imaging

  • Mark Liu Lab

    Research in the Mark Liu Lab explores several areas of pulmonary and respiratory medicine. Our studies primarily deal with allergic inflammation, chronic obstructive pulmonary disease (COPD) and asthma, specifically immunologic responses to asthma. We have worked to develop a microfluidic device with integrated ratiometric oxygen sensors to enable long-term control and monitoring of both chronic and cyclical hypoxia. In addition, we conduct research on topics such as the use of magnetic resonance angiography in evaluating intracranial vascular lesions and tumors as well as treatment of osteoporosis by deep sea water through bone regeneration.

    Research Areas: respiratory system, pulmonary medicine, asthma, COPD, inflammation, hypoxia

    Principal Investigator

    Mark Liu, M.D.

    Department

    Medicine

  • Naresh Punjabi Lab

    The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.

    Research Areas: epidemiology, type 2 diabetes, insulin resistance, cardiovascular diseases, sleep apnea

    Principal Investigator

    Naresh Punjabi, M.D., Ph.D.

    Department

    Medicine

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