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Research Lab Results for hypertension

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  • Charles Wiener Lab

    Principal Investigator:
    Charles Wiener, M.D.
    Medicine

    The Charles Wiener Lab primarily conducts research on pulmonary circulation and hypoxia as well... as respiratory muscle function in patients with neuromuscular diseases. Our recent studies have included investigating the treatment of pericardial effusions in patients with pulmonary arterial hypertension and examining the use of non-invasive ventilation in patients with amyotrophic lateral sclerosis (ALS). We also have an interest in medical education research. Our work in this area has included reviewing the role of academic medical centers in emerging health care markets. view more

    Research Areas: respiratory system, neuromuscular diseases, ALS, pulmonary medicine, hypertension, hypoxia
  • Edgar Miller Lab

    Principal Investigator:
    Edgar Miller, M.D., Ph.D.
    Medicine

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current... projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease. view more

    Research Areas: nutrition, kidney diseases, diabetes, inflammation
  • Hsin-Chieh Yeh Lab

    Lab Website
    Principal Investigator:
    Hsin-Chieh Yeh, Ph.D.
    Medicine

    Work in the Hsin-Chieh Yeh Lab focuses on clinical trials and cohort studies of diabetes, obesi...ty and behavioral intervention, cancer and hypertension. Recent investigations have focused on novel risk factors and complications related to obesity and type 2 diabetes, particularly lung function, smoking and cancer. We recently co-led a randomized clinical trial of tailored dietary advice for consumption of dietary supplements to lower blood pressure and improve cardiovascular disease risk factors in hypertensive urban African Americans. view more

    Research Areas: epidemiology, African Americans, cancer, obesity, hypertension, diabetes, behavioral medicine
  • Hsu Lab

    Principal Investigator:
    Steven Hsu, M.D.
    Medicine

    Our work is focused on the translational human in vivo and ex vivo assessments of right ventric...ular (RV) function in the setting of pulmonary hypertension.

    Among patients with group I pulmonary arterial hypertension PAH, those with systemic-sclerosis-associated PAH (SSc-PAH) have a particularly poor prognosis and less optimal response to PAH-guided therapy. Using in vivo pressure-volume catheterization of the right ventricle, we have uncovered key deficiencies in resting and reserve RV function in the SSc-PAH group when compared to idiopathic PAH (IPAH) patients. These studies have uncovered key discoveries with regards to right ventricular-pulmonary arterial (RV-PA) coupling in PAH. In the lab, by studying myofilament function from RV endomyocardial biopsies from these same patients, we have uncovered corresponding deficiencies in myofilament contractility and calcium sensitivity as well. Ongoing work is directed towards determining the underlying mechanism of these findings, which will hopefully lead to therapeutic applications for RV failure in SSc-PAH.

    Further endeavors are directed towards studying RV failure in other populations, including exercise-induced PH, PH secondary to left-heart disease, and the left ventricular assist device population.
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    Research Areas: pulmonary hypertension, exercise-induced pulmonary hypertension
  • Hypertension Center

    Lab Website

    The Hypertension Center at Johns Hopkins performs clinical research to advance the science of t...he diagnosis and treatment of hypertension. view more

    Research Areas: hypertension
  • J. Hunter Young Lab

    Principal Investigator:
    Jeffery Young, M.D., M.H.S.
    Medicine

    Research in the J. Hunter Young Lab focuses on the genetic epidemiology and physiology of cardi...ovascular disease and its risk factors, especially hypertension, diabetes and obesity. Current activities include an observational study of hypertension among African Americans; a genetic epidemiology study of worldwide cardiovascular disease susceptibility patterns; and several population-based observational studies of cardiovascular and renal disease. A recent focus group study found that changes in housing and city policies might lead to improved environmental health conditions for public housing residents. view more

    Research Areas: epidemiology, kidney diseases, obesity, hypertension, diabetes, genomics, physiology, cardiovascular diseases
  • James Sham Lab

    Principal Investigator:
    James Sham, Ph.D.
    Medicine

    Research in the James Sham Lab focuses on pulmonary arteries. Studies include local calcium sig...naling in the pulmonary arteries and transient receptor potential (TRP) channels in pulmonary arterial smooth muscle cells. We’re also interested in calcium regulation in chronic hypoxic pulmonary hypertension. view more

    Research Areas: chronic hypoxic pulmonary hypertension, pulmonary medicine, arteries
  • Kass Lab

    Lab Website
    Principal Investigator:
    David Kass, M.D.
    Medicine

    Basic science investigations span an array of inquiries, such as understanding the basic mechan...isms underlying cardiac dyssynchrony and resynchronization in the failing heart, and beneficial influences of nitric oxide/cGMP/protein kinase G and cGMP-targeted phosphdiesterase signaling cascades on cardiac maladaptive stress remodeling. Recently, the latter has particularly focused on the role of phosphodiesterase type 5 and its pharmacologic inhibitors (e.g. sildenafi, Viagra®), on myocyte signaling cascades modulated by protein kinase G, and on the nitric oxide synthase dysregulation coupled with oxidant stress.

    The lab also conducts clinical research and is presently exploring new treatments for heart failure with a preserved ejection fraction, studying ventricular-arterial interaction and its role in adverse heart-vessel coupling in left heart failure and pulmonary hypertension, and testing new drug, device, and cell therapies for heart disease. A major theme has been with the use of advanced non-invasive and invasive catheterization-based methods to assess cardiac mechanics in patients.asive and invasive catheterization-based methods to assess cardiac mechanics in patients.

    David Kass, MD, is currently the Director at the Johns Hopkins Center for Molecular Cardiobiology and a professor in cellular and molecular medicine.
    view more

    Research Areas: pulmonary hypertension, heart disease, cardiac hypertrophy, heart failure, cardiology
  • Kathryn Carson Lab

    Principal Investigator:
    Kathryn Carson, Sc.M.
    Medicine

    The Kathryn Carson Lab investigates ways to improve medical research, particularly in the areas... of brain and thyroid cancer, Alzheimer’s disease, atherosclerosis, hypertension, HIV and lupus. Our team seeks to help researchers optimize their studies through better study design, protocol and grant writing, data cleaning and analysis, and publication writing. We work with investigators from a wide range of departments through the Johns Hopkins Institute for Clinical and Translational Research. view more

    Research Areas: epidemiology, lupus, research methods, data analysis, cancer, hypertension, clinical trials, HIV, biostatistics, Alzheimer's disease
  • Larissa Shimoda Lab

    Principal Investigator:
    Larissa Shimoda, Ph.D., M.S.
    Medicine

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and cr...itical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodeling in patients with pulmonary hypertension. view more

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia
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