Skip Navigation

Find a Research Lab

Research Lab Results for homeostasis

Displaying 1 to 13 of 13 results
Results per page:
  • Anderson Lab

    Lab Website
    Principal Investigator:
    Mark Anderson, M.D., Ph.D.
    Medicine

    Research in the Anderson laboratory focuses on cellular signaling and ionic mechanisms that cau...se heart failure, arrhythmias and sudden cardiac death, major public health problems worldwide. Primary focus is on the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII). The laboratory identified CaMKII as an important pro-arrhythmic and pro-cardiomyopathic signal, and its studies have provided proof of concept evidence motivating active efforts in biotech and the pharmaceutical industry to develop therapeutic CaMKII inhibitory drugs to treat heart failure and arrhythmias.

    Under physiological conditions, CaMKII is important for excitation-contraction coupling and fight or flight increases in heart rate. However, myocardial CaMKII is excessively activated during disease conditions where it contributes to loss of intracellular Ca2+ homeostasis, membrane hyperexcitability, premature cell death, and hypertrophic and inflammatory transcription. These downstream targets appear to contribute coordinately and decisively to heart failure and arrhythmias. Recently, researchers developed evidence that CaMKII also participates in asthma.

    Efforts at the laboratory, funded by grants from the National Institutes of Health, are highly collaborative and involve undergraduate assistants, graduate students, postdoctoral fellows and faculty. Key areas of focus are:
    • Ion channel biology and arrhythmias
    • Cardiac pacemaker physiology and disease
    • Molecular physiology of CaMKII
    • Myocardial and mitochondrial metabolism
    • CaMKII and reactive oxygen species in asthma

    Mark Anderson, MD, is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital.
    view more

    Research Areas: heart failure, arrhythmia, cardiovascular diseases, sudden cardiac death
  • Dwight Bergles Laboratory

    Lab Website
    Principal Investigator:
    Dwight Bergles, Ph.D.
    Neuroscience

    The Bergles Laboratory studies synaptic physiology, with an emphasis on glutamate transporters ...and glial involvement in neuronal signaling. We are interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. The lab studies glutamate transport physiology and function. Because glutamate transporters play a critical role in glutamate homeostasis, understanding the transporters' function is relevant to numerous neurological ailments, including stroke, epilepsy, and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Other research in the laboratory focuses on signaling between neurons and glial cells at synapses. Understanding how neurons and cells communicate, may lead to new approaches for stimulating re-myelination following injury or disease. Additional research in the lab examines how a unique form of glia-to-neuron signaling in the cochlea influences auditory system development, whether defects in cell communication lead to certain hereditary forms of hearing impairment, and if similar mechanisms are related to sound-induced tinnitus. view more

    Research Areas: epilepsy, synaptic physiology, ALS, stroke, neuronal signaling, glutamate transport physiology and function, audiology, neuroscience, neurology, nervous system, molecular biology
  • Enid Neptune Lab

    Principal Investigator:
    Enid Neptune, M.D.
    Medicine

    Work in the Enid Neptune Lab focuses on topics within the fields of pulmonary and critical care... medicine. Our research centers primarily on therapeutic strategies for Marfan syndrome and hepatocyte growth factor signaling in airspace homeostasis. We also conduct research on chronic obstructive pulmonary disease (COPD), with a focus on its mechanisms and potential methods for preventing its progression. Our research within critical care has most recently involved investigating superoxide dismutase 3 dysregulation in neonatal lung injuries. view more

    Research Areas: critical care medicine, pulmonary medicine, COPD, Marfan syndrome
  • Espenshade Lab

    Lab Website
    Principal Investigator:
    Peter Espenshade, Ph.D.
    Cell Biology

    The Espenshade Lab uses a multi-organismal and multidisciplinary approach to understand how euk...aryotic cells measure insoluble lipids and dissolved gases. We have chosen cholesterol and oxygen as our model molecules, based on their essential roles in cell function and the importance of their proper homeostasis for human health. view more

    Research Areas: cell biology, oxygen, eukaryotic cells, cholesterol
  • Gregg Semenza Lab

    Principal Investigator:
    Gregg Semenza, M.D., Ph.D.
    Pediatrics

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned an...d characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.
    view more

    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia
  • Guang William Wong Lab

    Principal Investigator:
    Guang Wong, Ph.D.
    Physiology

    The Wong Lab seeks to understand mechanisms employed by cells and tissues to maintain metabolic... homeostasis. We are currently addressing how adipose- and skeletal muscle-derived hormones (adipokines and myokines), discovered in our lab, regulate tissue crosstalk and signaling pathways to control energy metabolism. We use transgenic and knockout mouse models, as well as cell culture systems, to address the role of the CTRP family of hormones in physiological and disease states. We also aim to identify the receptors that mediate the biological functions of CTRPs. view more

    Research Areas: energy metabolism, insulin resistance, hormones, diabetes, metabolic homeostasis
  • Intestinal Na/H Exchangers

    Principal Investigator:
    Ming-Tseh Lin, M.D., Ph.D.
    Medicine

    Secretory diarrhea is a leading cause of childhood morbidity and mortality in developing countr...ies. While diarrhea can be treated with oral rehydration solution (ORS), inclusion of zinc with oral ORS has been shown to reduce the duration of diarrhea. However, how zinc improves diarrhea is not known.

    It has been shown that zinc acts as an intestinal epithelial cell basolateral potassium channel blocker of cyclic AMP-mediated chloride secretion. We discovered that zinc also stimulates intestinal sodium and water absorption via the epithelial Na/H exchanger, NHE3. Zinc reverses the effect of cyclic AMP inhibition of NHE3 activity. The effect of zinc on NHE3 cannot be duplicated with other divalent metal ions. It has been well established that Na/H exchanger regulatory proteins are involved in NHE3 regulation.

    Whether these regulatory proteins are involved in zinc stimulation of NHE3 is a focus of our study. Our goal is to reveal mechanisms to explain how zinc improves diarrhea and to understand the role of zinc in salt and water homeostasis in the gut. Our study will provide a scientific basis to justify the inclusion of zinc in ORS for the treatment of secretory diarrhea.
    view more

    Research Areas: gastroenterology, diarrhea
  • Laboratory of Airway Immunity

    We are interested in understanding how innate immune responses regulate lung health. Innate imm...unity involves ancient, and well-conserved mediators and their actions regulate the balance between homeostasis and pathogenesis. In the lungs, innate immunity play a critical role in response to environmental exposures such as allergen and ambient particulate matter. My lab focuses on how these exposures can promote aberrant mucosal responses that can drive the development of diseases like asthma. view more

    Research Areas: allergy, type 2 immunity, asthma, particulate matter, allergens, innate immunity
  • Landon King Lab

    Principal Investigator:
    Landon King, M.D.
    Medicine

    The Landon King Lab studies aquaporins water-specific membrane channel proteins. We hope to und...erstand how these proteins contribute to water homeostasis in the respiratory tract and how their expression or function may be altered in disease states. view more

    Research Areas: respiratory system, proteomics, aquaporins
  • Suzanne Jan de Beur Lab

    Principal Investigator:
    Suzanne Jan De Beur, M.D.
    Medicine

    Researchers in the Suzanne Jan de Beur Lab are interested in bone and mineral metabolism, endoc...rinology and osteoporosis. In addition, we focus on hormonal regulators of phosphate homeostasis, parathyroid hormone signaling and the molecular basis of hypophosphatemic disorders. view more

    Research Areas: osteoporosis, metabolism, diabetes, endocrinology
  • Svetlana Lutsenko Laboratory

    Lab Website
    Principal Investigator:
    Svetlana Lutsenko, Ph.D.
    Physiology

    The research in the Svetlana Lutsenko Laboratory is focused on the molecular mechanisms that re...gulate copper concentration in normal and diseased human cells. Copper is essential for human cell homeostasis. It is required for embryonic development and neuronal function, and the disruption of copper transport in human cells results in severe multisystem disorders, such as Menkes disease and Wilson's disease. To understand the molecular mechanisms of copper homeostasis in normal and diseased human cells, we utilize a multidisciplinary approach involving biochemical and biophysical studies of molecules involved in copper transport, cell biological studies of copper signaling, and analysis of copper-induced pathologies using Wilson's disease gene knock-out mice. view more

    Research Areas: biophysics, biochemistry, menkes disease, Wilson's disease, cell biology, multisystem disorders, physiology, copper, molecular biology
  • The Sun Laboratory

    Lab Website
    Principal Investigator:
    Shuying Sun, Ph.D.
    Pathology

    The nervous system has extremely complex RNA processing regulation. Dysfunction of RNA metaboli...sm has emerged to play crucial roles in multiple neurological diseases. Mutations and pathologies of several RNA-binding proteins are found to be associated with neurodegeneration in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). An alternative RNA-mediated toxicity arises from microsatellite repeat instability in the human genome. The expanded repeat-containing RNAs could potentially induce neuron toxicity by disrupting protein and RNA homeostasis through various mechanisms.

    The Sun Lab is interested in deciphering the RNA processing pathways altered by the ALS-causative mutants to uncover the mechanisms of toxicity and molecular basis of cell type-selective vulnerability. Another major focus of the group is to identify small molecule and genetic inhibitors of neuron toxic factors using various high-throughput screening platforms. Finally, we are also highly interested in developing novel CRISPR technique-based therapeutic strategies. We seek to translate the mechanistic findings at molecular level to therapeutic target development to advance treatment options against neurodegenerative diseases.
    view more

    Research Areas: ALS, neurodegeneration, RNA
  1. 1
Create lab profile
Edit lab profile
back to top button