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Displaying 1 to 16 of 16 results for hepatitis C

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  • Andrea Cox Lab

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design.

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells

    Principal Investigator

    Andrea Cox, M.D., Ph.D.

    Department

    Medicine

  • Anna Durbin Lab

    The Anna Durbin Lab evaluates experimental vaccines through human clinical trials. We have conducted both pediatric and adult clinical trials on vaccines for HIV, hepatitis C, HPV, influenza, malaria, dengue virus, rotavirus and other viruses. We also have a longstanding interest in better understanding the immunologic factors of dengue infection and disease. We’re working to identify the viral, host and immunologic factors that cause severe dengue illness.

    Research Areas: dengue fever, epidemiology, international health, vaccines, HPV, clinical trials, HIV, malaria, hepatitis C, flu

    Lab Website

    Principal Investigator

    Anna Durbin, M.D.

    Department

    Medicine

  • Ashwin Balagopal Lab

    Research in the Ashwin Balagopal Lab examines innate immunology and hepatic inflammation. Specifically, we explore microbial translocation Kupffer cells in HIV- hepatitis C virus (HCV) coinfection, while also developing in situ liver studies of HIV-HCV pathogenesis. Previous work has focused on antiretroviral therapy, interferon sensitivity and virologic setpoint in HIV/hepatitis C virus coinfected patients.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, HIV, hepatitis C

    Principal Investigator

    Ashwin Balagopal, M.D.

    Department

    Medicine

  • Chloe Thio Lab

    Research in the Chloe Thio lab focuses on several areas. First, HBV virology and immunology in HBV monoinfected and HIV-HBV co-infected individuals that will ultimately help develop a cure for HBV. Second, HCV infection in men who have sex with men. Third, non-alcoholic fatty liver disease with a focus on HIV-infected individuals. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance.

    Research Areas: HIV-HBV co-infection, hepatitis B, genomics, hepatitis C, fatty liver

    Principal Investigator

    Chloe Thio, M.D.

    Department

    Medicine

  • Christine Durand Lab

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopkins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased ...donor liver transplantation. view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C

    Principal Investigator

    Christine Durand, M.D.

    Department

    Medicine

  • David Thomas Lab

    The David Thomas Lab oversees clinical research projects that aim to understand the natural history and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people.

    Research Areas: HIV, hepatitis C, liver diseases

    Principal Investigator

    David Thomas, M.D., M.P.H.

    Department

    Medicine

  • Ernesto Freire Laboratory

    The Ernesto Freire Lab studies the use of novel drugs to treat disease. Our research has resulted in the development of a thermodynamic platform for drug discovery and optimization. Our aim is to achieve high binding affinity and selectivity as well as appropriate pharmacokinetics with the platform. We are currently focusing on drug targets such as HIV/-1 protease inhibitors (HIV/AIDS), plasmepsin inhibitors (malaria), HCV protease inhibitors (hepatitis C), coronavirus 3CL-pro protease inhibitors (SARS and other viral infections), HIV-1 gp120 inhibitors (HIV/AIDS), chymase inhibitors (cardiovascular disease) and beta lactamase inhibitors (antibiotic resistance).

    Research Areas: pharmaceuticals, thermodynamics, AIDS, drug discovery, HIV, protease inhibitors, malaria

  • Geetanjali Chander Lab

    Our research focuses at the nexus of HIV and alcohol and other substance use. We examine epidemiological aspects of HIV and alcohol use/other drug use among persons with HIV (PWH), and work on the adaptation and testing of person and computer-delivered interventions for unhealthy alcohol use, particularly among women.

    Research Areas: Ressearch at the intersection of alcohol and other substance use and HIV, intervention, substance abuse, alcohol use, HIV, hepatitis C

    Principal Investigator

    Geetanjali Chander, M.D., M.P.H.

    Department

    Medicine

  • Gregory Kirk Lab

    Research in the Gregory Kirk Lab examines the natural history of viral infections — particularly HIV and hepatitis viruses — in the U.S. and globally. As part of the ALIVE (AIDS Linked to the Intravenous Experience) study, our research looks at a range of pathogenetic, clinical behavioral issues, with a special focus on non-AIDS-related outcomes of HIV, including cancer and liver and lung diseases. We use imaging and clinical, genetic, epigenetic and proteomic methods to identify and learn more about people at greatest risk for clinically relevant outcomes from HIV, hepatitis B and hepatitis C infections. Our long-term goal is to translate our findings into targeted interventions that help reduce the disease burden of these infections.

    Research Areas: global health, Hepatitis, Africa, AIDS, cancer, HIV, drugs, liver diseases

    Principal Investigator

    Gregory Kirk, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Justin Bailey Lab

    Research in the Justin Bailey Lab explores immune responses against hepatitis C virus (HCV), particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. Recent studies have demonstrated that early and broad neutralizing antibody (nAb) responses against HCV are associated with HCV clearance, suggesting a key role for nAb in limiting HCV replication. The findings of this research will enhance understanding of how HIV infection may contribute to the lower rate of HCV clearance in HCV/HIV coinfected individuals, and the results could have implications for persistence of other viruses commonly occurring as coinfections with HIV.

    Research Areas: humoral immune response, vaccines, infectious disease, AIDS, HIV, hepatitis C

    Lab Website

    Principal Investigator

    Justin Bailey, M.D., Ph.D.

    Department

    Medicine

  • Kelly Gebo Lab

    Work in the Kelly Gebo Lab focuses on topics such as evidence-based practice, health utilization, policy generation, health disparities in patient access to health care, HIV/AIDS, aging and hepatitis. As part of the HIV Research Network (HIVRN), our lab gathers clinical and demographic data on HIV-infected patients to help develop a single, nationwide research database. In addition, our ongoing research explores evidence-based practice in relation to the management of hepatitis C as well as HIV/AIDS in mentally ill patients. We also investigate racial and gender disparities in patients who receive highly active antiretroviral therapy.

    Research Areas: Hepatitis, AIDS, HIV, aging, health care policy, evidence-based medicine, health disparities

    Principal Investigator

    Kelly Gebo, M.D., M.P.H.

    Department

    Medicine

  • Mark Sulkowski Lab

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

    Research Areas: infectious disease, hepatitis B, hepatitis C

    Lab Website

    Principal Investigator

    Mark Sulkowski, M.D.

    Department

    Medicine

  • Michael Melia Lab

    Research in the Michael Melia Lab focuses primarily on nocardia infections, Lyme disease and hepatitis C. Our studies have included key topics such as risk factors for incident infections during hepatitis C treatment, racial differences in eligibility for hepatitis C treatment and misdiagnosis of Lyme arthritis using the Borrelia burgdorferi immunoblot testing method. We also have a longstanding interest in medical education and work on curriculum to improve the quality of education for medical students and interns.

    Research Areas: medical education, nocardia infections, infectious disease, AIDS, HIV, Lyme disease, hepatitis C

    Principal Investigator

    Michael Melia, M.D.

    Department

    Medicine

  • Mohamed Atta Lab

    Research in the Mohamed Atta Lab focuses on kidney diseases in patients with HIV. We recently reviewed the published nephrotoxic effects of newer antiviral therapies for HIV and hepatitis C, specifically looking at the role of epithelial organic transporters in explaining renal toxicities. We also examined the relationship between the APOL1 genotype and renal histology among black patients with HIV who had undergone kidney biopsies.

    Research Areas: kidney diseases, HIV, hepatitis C

    Principal Investigator

    Mohamed Atta, M.B.B.Ch., M.D., M.P.H.

    Department

    Medicine

  • Namandje N. Bumpus Lab

    The Bumpus Laboratory uses mass spectrometry and molecular pharmacology-based approaches to study the biotransformation of clinically used drugs by the cytochromes P450s. Specifically, we are studying ways to define a role for cytochrome P450-dependent metabolites in the drug-induced acute liver failure that is associated with certain antiviral drugs used to treat HIV and hepatitis C. Our long-term goal is to gain information that can be used to develop therapies that are devoid of toxic events by preventing the formation of a toxic metabolite or by developing strategies for preventing toxicity using concomitant therapy.

    Research Areas: antiviral therapy, drug metabolism, mass spectrometry, HIV, drugs, cellular signaling, cytochromes P450, pharmacology, molecular pharmacology, hepatitis C, metabolomics

    Lab Website

    Principal Investigator

    Namandje Bumpus, Ph.D.

    Department

    Medicine

  • Stuart C. Ray Lab

    Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and an increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV.

    Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology

    Lab Website

    Principal Investigator

    Stuart Ray, M.D.

    Department

    Medicine

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