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• Eun Ji Shin Lab

  Research interests in the Eun Ji Shin Lab include clinical research on obesity and the effect on GI neoplasia/malignancy.

  Research Areas: gastroenterology, neoplasms, obesity

  

  Principal Investigator

  Eun Shin, M.D.

  Department

  Medicine
  

• Florin Selaru Lab

  Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.

  Research Areas: gastroenterology, cancer, inflammation, molecular biology

  

  Principal Investigator

  Florin Selaru, M.D.

  Department

  Medicine
  

• James Potter Lab

  The James Potter Lab studies the effect of ethanol and its metabolites on the a2(I) and a1(I) collagen promoters; the role of leptin on fibrogenesis; the role of Kupffer cells, cytokines, retinoic acid and leptin in stellate cell tansdifferentiation and collagen production; hormonal regulation of rat class I alcohol dehydrogenase; and transcriptional regulation of rat class I alcohol dehydrogenase promotor.

  Research Areas: collagen, gastroenterology, cytokines, ethanol, fibrogenesis

  

  Principal Investigator

  James Potter

  Department

  Medicine
  

• Joanna Peloquin Lab

  The Joanna Peloquin Lab focuses on inflammatory bowel disease (IBD). We're working on individualized care for IBD patients through functional genomic studies, specifically those related to diet, host and microbiota interactions.

  Research Areas: inflammatory bowel disease, gastroenterology, nutrition, microbiota, genomics

  

  Principal Investigator

  Joanna Melia, M.D.

  Department

  Medicine
  

• Mark Donowitz Lab

  Research in the Mark Donowitz Lab is primarily focused on the development of drug therapy for diarrheal disorders, intestinal salt absorption and the proteins involved including their regulation, and the use of human enteroids to understand intestinal physiology and pathophysiology. We study two gene families initially recognized by this laboratory: mammalian Na/H exchangers and the subgroup of PDZ domain containing proteins present in the brush border of epithelial cells called NHERF family. A major finding is that NHE3 exists simultaneously in different sized complexes in the brush border, which change separately as part of signal transduction initiated by mimics of the digestive process. Relevance to the human intestine is being pursued using mini-human intestine made from Lgr5+ stems cells made from intestinal biopsies and measuring function via two-photon microscopy.

  Research Areas: gastrointestinal system, gastroenterology, pathophysiology, diarrhea, drugs, physiology

  Lab Website

  

  Principal Investigator

  Mark Donowitz, M.D.

  Department

  Medicine
  

• Pankaj Jay Pasricha Lab

  Researchers in the Pankaj Jay Pasricha Lab are interested in the molecular mechanisms of visceral pain and restoration of enteric neural function with novel strategies, including neural stem cell transplants. Recent research has focused on the enteric nervous system and gut-brain axis, and the complexity of pain in chronic pancreatitis. Another recent study indicates that patients with underlying small intestinal bacterial overgrowth have significant delays in small bowel transit time as compared to those without, while another explored the safety and efficacy of carbon dioxide cryotherapy for treatment of neoplastic Barrett's esophagus.

  Research Areas: gastroenterology, stem cells, neurogastroenterology, pancreatitis, pain, Barrett's esophagus, motility disorders

  

  Principal Investigator

  Jay Pasricha, M.B.B.S., M.D.

  Department

  Medicine
  

• Sharon Dudley Brown Lab

  Research in the Sharon Dudley Brown Lab focuses on gastroenterology and hepatology, inflammatory bowel disease and ulcerative colitis.

  Research Areas: inflammatory bowel disease, gastroenterology, hepatology, ulcerative colitis

  

  Principal Investigator

  Sharon Dudley-Brown, Ph.D.

  Department

  Medicine
  

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