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The overall goal of the Auditory Brainstem Library is to understand how abnormal auditory input from the ear affects the brainstem, and how the brain in turn affects activity in the ear through efferent feedback loops. Our emphasis is on understanding the effects of different forms of acquired hearing loss (genetic, conductive, noise-induced, age-related, traumatic brain injury-related) and environmental noise. We are particularly interested in plastic changes in the brain that compensate for some aspects of altered auditory input, and how those changes relate to central auditory processing deficits, tinnitus, and hyperacusis. Understanding these changes will help refine therapeutic strategies and identify new targets for treatment. We collaborate with other labs in the Depts. of Otolaryngology, Neuroscience, Neuropathology, the Wilmer Eye Institute, and the Applied Physics Laboratory at Johns Hopkins, in addition to labs outside the university to increase the impact and clinical relev...ance of our research. view more
The Center for Nanomedicine engineers drug and gene delivery technologies that have significant implications for the prevention, treatment and cure of many major diseases facing the world today. Specifically, we are focusing on the eye, central nervous system, respiratory system, women's health, gastrointestinal system, cancer, and inflammation.
We are a unique translational nanotechnology effort located that brings together engineers, scientists and clinicians working under one roof on translation of novel drug and gene delivery technologies
Utilizing a combination of tissue-based, cell-based, and molecular approaches, our research goals focus on abnormal telomere biology as it relates to cancer initiation and tumor progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype. In addition, our laboratories focus on cancer biomarker discovery and validation with the ultimate aim to utilize these novel tissue-based biomarkers to improve individualized prevention, detection, and treatment strategies.
The APL Health Technologies program's functional restoration focus area includes two portfolios with particular relevance in neurology. The first focuses on motor restoration, using teams with expertise in robotics, microsensors, haptics, artificial intelligence and brain-machine interfaces. One set of projects, currently sponsored by Defense Advanced Research Projects Agency (DARPA) and the Henry Jackson Foundation, centers on a bionic arm technology that integrates with bone and muscle in amputee patients, restoring a variety of normal functions to the patient like cooking, folding clothing, hand shaking, and hand gestures. This portfolio explores direct brain control of the bionic limb, through work led by Dr. Nathan Crone of Johns Hopkins Neurology and Dr. Pablo Celnik of Johns Hopkins Physical Medicine and Rehabilitation. Another set of related work aims to restore motor function by better understanding and using brain signals through brain-machine interfaces. This work is current...ly funded by the National Science Foundation and industry partners. Also in the functional restoration focus area is the vision restoration portfolio. In a partnership with Second Sight and the Mann Fund, the work aims to enhance function of a bionic eye, which couples a retinal implant with a computer vision system to restore vision in blind individuals with retinitis pigmentosa. Current work in the human-machine teaming focus area includes a portfolio that is building artificial intelligence systems that improve radiologic and ophthalmic diagnostics. Another portfolio, currently focused in the surgical setting, enhances the physician's ability to visualize and manipulate the physical world, such as with orthopaedic surgery. view less
Neuro-Vestibular and Ocular Motor Laboratory
In our laboratory we study the brain mechanisms of eye movements and spatial orientation.
-How magnetic stimulation through transcranial devices affects cortical brain regions
-Neural mechanisms underlying balance, spatial orientation and eye movement
-Mathematical models that describe the function of ocular motor systems and perception of spatial orientation
-Short- and long-term adaptive processes underlying compensation for disease and functional recovery in patients with ocular motor, vestibular and perceptual dysfunction
Developing and testing novel diagnostic tools, treatments, and rehabilitative strategies for patients with ocular motor, vestibular and spatial dysfunction
Our research is directed toward how the brain controls the movements of the eyes (including eye movements induced by head motion) using studies in normal human beings, patients and experimental animals. The focus is on mechanisms underlying adaptive ocular motor control. More specifically, what are mechanisms by which the brain learns to cope with the changes associated with normal development and aging as well as the damage associated with disease and trauma? How does the brain keep its eye movement reflexes properly calibrated? Our research strategy is to make accurate, quantitative measures of eye movements in response to precisely controlled stimuli and then use the analytical techniques of the control systems engineer to interpret the findings.
Research areas: 1) learning and compensation for vestibular disturbances that occur either within the labyrinth or more centrally within the brain, 2) the mechanisms by which the brain maintains correct alignment of the eyes to prevent d...iplopia and strabismus, and 3) the role of ocular proprioception in localizing objects in space for accurate eye-hand coordination.
The lab studies the development of blood vessels in the eye and how they change in diseases like retinopathy of prematurity, sickle cell and diabetic retinopathies, and age-related macular degeneration (AMD). The ultimate goal of the lab is to develop a new generation of therapies that, when delivered to the eye, allow the tissues of the eye to essentially treat themselves only when needed. The goal is to have the tissues generate their own therapeutics when needed, and stop production when the condition is resolved. These therapies will help reduce the need for repeated treatment and provide focused therapy, rather than treating the body with chemicals.
Research in the Vestibular NeuroEngineering Lab (VNEL) focuses on restoring inner ear function through “bionic” electrical stimulation, inner ear gene therapy, and enhancing the central nervous system’s ability to learn ways to use sensory input from a damaged inner ear. VNEL research involves basic and applied neurophysiology, biomedical engineering, clinical investigation and population-based epidemiologic studies. We employ techniques including single-unit electrophysiologic recording; histologic examination; 3-D video-oculography and magnetic scleral search coil measurements of eye movements; microCT; micro MRI; and finite element analysis. Our research subjects include computer models, circuits, animals and humans. For more information about VNEL, click here.
VNEL is currently recruiting subjects for two first-in-human clinical trials:
1) The MVI Multichannel Vestibular Implant Trial involves implantation of a “bionic” inner ear stimulator intended to partially restore sensation... of head movement. Without that sensation, the brain’s image- and posture-stabilizing reflexes fail, so affected individuals suffer difficulty with blurry vision, unsteady walking, chronic dizziness, mental fogginess and a high risk of falling. Based on designs developed and tested successfully in animals over the past the past 15 years at VNEL, the system used in this trial is very similar to a cochlear implant (in fact, future versions could include cochlear electrodes for use in patients who also have hearing loss). Instead of a microphone and cochlear electrodes, it uses gyroscopes to sense head movement, and its electrodes are implanted in the vestibular labyrinth. For more information on the MVI trial, click here.
2) The CGF166 Inner Ear Gene Therapy Trial involves inner ear injection of a genetically engineered DNA sequence intended to restore hearing and balance sensation by creating new sensory cells (called “hair cells”). Performed at VNEL with the support of Novartis and through a collaboration with the University of Kansas and Columbia University, this is the world’s first trial of inner ear gene therapy in human subjects. Individuals with severe or profound hearing loss in both ears are invited to participate. For more information on the CGF166 trial, click here. view more
The mission of the laboratory of vestibular neurophysiology is to advance the understanding of how the body perceives head motion and maintains balance - a complex and vital function of everyday life. Although much is known about the vestibular part of the inner ear, key aspects of how the vestibular receptors perceive, process and report essential information are still mysterious. Increasing our understanding of this process will have tremendous impact on quality of life of patients with vestibular disorders, who often suffer terrible discomfort from dizziness and vertigo.
The laboratory group's basic science research focuses on the vestibulo-ocular reflexes - the reflexes that move the eyes in response to motions of the head. They do this by studying the vestibular sensors and nerve cells that provide input to the reflexes; by studying eye movements in humans and animals with different vestibular disorders, by studying effects of electrical stimulation of vestibular sensors, and b...y using mathematical models to describe these reflexes. Researchers are particularly interested in abnormalities of the brain's inability to compensate for vestibular disorders.