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Displaying 1 to 10 of 14 results for epigenetics

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  • Alison Moliterno Lab

    The Alison Moliterno Lab studies the molecular pathogenesis of myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocytosis and idiopathic myelofibrosis. Our research is focused on the genetic and epigenetic lesions associated with MPDs, with the goal of improving diagnosis and treatment for these disorders.

    Research Areas: blood disorders, idiopathic myelofibrosis, essential thrombocytosis, epigenetics, genomics, polycythemia vera, myeloproliferative disorders

    Principal Investigator

    Alison Moliterno, M.D.

    Department

    Medicine

  • Andrew Feinberg Laboratory

    The Feinberg Laboratory studies the epigenetic basis of normal development and disease, including cancer, aging and neuropsychiatric illness. Early work from our group involved the discovery of altered DNA methylation in cancer as well as common epigenetic (methylation and imprinting) variants in the population that may be responsible for a significant population-attributable risk of cancer.

    Over the last few years, we have pioneered the field of epigenomics (i.e., epigenetics at a genome-scale level), founding the first NIH-supported NIH epigenome center in the country and developing many novel tools for molecular and statistical analysis. Current research examines the mechanisms of epigenetic modification, the epigenetic basis of cancer, the invention of new molecular, statistical, and epidemiological tools for genome-scale epigenetics and the epigenetic basis of neuropsychiatric disease, including schizophrenia and autism.

    Research Areas: autism, cancer, epigenetics, schizophrenia, human development, aging, DNA, genomics, neuropsychiatric disease

    Lab Website

    Principal Investigator

    Andrew Feinberg, M.D., M.P.H.

    Department

    Medicine

  • Constance Monitto Lab

    The Constance Monitto Lab conducts clinical research on pediatric pain management as well as basic science studies on chemotherapy resistance. In our pediatric pain management research, we work to assess the impact of low-dose opioid antagonism on opioid-related side effects, such as nausea and vomiting. We also analyze data on current methods of pediatric pain management in the United States. In addition, our team uses basic science studies to assess the success of epigenetic gene regulation on the development of resistance to chemotherapeutic agents in cancer.

    Research Areas: chemotherapy, opioids, epigenetics, gene regulation, pain, pediatrics

  • Daria Gaykalova Lab

    The Daria Gakalova Lab defines the functional role of epigenetics in transcriptional regulation of head and neck squamous cell carcinoma (HNSCC) progression. To evaluate the whole-genome distribution of various histone marks, her team is using chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-Seq) for primary tissues, a method recently developed by her lab. The research group of Daria Gaykalova was the first to demonstrate the cancer-specific distribution of H3K4me3 and H3K27ac marks and their role in cancer-related gene expression in HNSCC. The research showed that an aberrant chromatin alteration is a central event in carcinogenesis and that the therapeutic control of chromatin structure can prevent the primary of secondary cancerization. Further preliminary data suggest that the differential enrichment of these disease-specific histone marks and DNA methylation correlate with alternative splicing events (ASE) formation. For this project, Dr. Gaykalova... and her team employed a novel bioinformatical tool for the detection of cancer-specific ASEs. Through thorough functional validation of the individual ASEs, the lab demonstrated that each of them has a unique mechanism of malignant transformation of the cells. Due to high disease specificity, ASEs represent the perfect biomarkers of the neoantigens and have direct application to clinical practice. view more

    Research Areas: Head and neck squamous cell carcinoma, Human papillomavirus, Alternative splicing, epigenetics, Chromatin structure, Cancer genomics, head and neck cancer

  • Early Detection of Pancreatic Cancer Laboratory

    The goal of the lab's research is to identify molecular abnormalities that can improve the outcome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer.

    Thus, marker efforts have been focused mostly on identifying markers of advanced precancerous neoplasia (PanINs and IPMNs) that could improve our ability to effectively screen patients at risk of developing pancreatic cancer. We lead or participate in a number of clinical research protocols involved in the screening and early detection of pancreatic neoplasia including the CAPS clinical trials. We maintain a large repository of specimens from cases and controls with and without pancreatic disease and use this repository to investigate candidate markers of pancreatic cancer for their utility to predict pancreatic cancer risk.
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    In addition, we have been working to identify familial pancreatic cancer susceptibility genes and identified BRCA2 as a pancreatic cancer susceptibility gene in 1996. We participate in the PACGENE consortium and the familial pancreatic cancer sequencing initiative. My lab also investigates pancreatic cancer genetics, epigenetics, molecular pathology, tumor stromal interactions and functional analysis of candidate genes and miRNAs. Dr. Goggins is the principal investigator of a phase I/II clinical trial evaluating the Parp inhibitor, olaparib along with irinotecan and cisplatin for patients with pancreatic cancer.
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    Research Areas: pancreatic cancer

    Lab Website

    Principal Investigator

    Michael Goggins, M.B.B.Ch., M.D.

    Department

    Medicine

  • GI Biomarkers Laboratory

    The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.

    Research Areas: gastrointestinal system, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis

    Lab Website

    Principal Investigator

    Stephen Meltzer, M.D.

    Department

    Medicine

  • Karen Reddy Laboratory

    The focus of the research in the Reddy Laboratory is to begin to understand how the nuclear periphery and other subcompartments contribute to general nuclear architecture and to specific gene regulation. Our research goals can be broken down into three complementary areas of research: understanding how genes are regulated at the nuclear periphery, deciphering how genes are localized (or "addressed") to specific nuclear compartments and how these processes are utilized in development and corrupted in disease.

    Research Areas: biological chemistry, cell biology, nuclear structure, epigenetics, gene regulation

    Principal Investigator

    Karen Reddy, Ph.D.

    Department

    Biological Chemistry

  • Li Gao Lab

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex cardiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lung diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis.

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis

    Principal Investigator

    Li Gao, M.D., Ph.D.

    Department

    Medicine

  • Michael Mingzhao Xing Lab

    Investigators in the Michael Mingzhao Xing Lab study the cellular and molecular mechanisms of thyroid cancer, including its genetic and epigenetic alterations and related cellular behaviors. We are particularly interested in exploring cellular and molecular derangements associated with the MAP kinase and PI3K/Akt pathways as a fundamental mechanism in thyroid tumorigenesis. The clinical translation of research findings is an important focus for us. Examples include the team’s demonstrations of the prognostic value of the BRAF mutation for risk stratification of thyroid cancer, as well as its preoperative value when tested on thyroid fine-needle biopsy specimens.

    Research Areas: thyroid cancer, molecular genetics, epigenetics, genomics

    Lab Website

    Principal Investigator

    Michael Xing, M.D., Ph.D.

    Department

    Medicine

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