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Displaying 41 to 57 of 57 results for epidemiology

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  • Post Lab

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative study of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coron...ary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
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    Research Areas: coronary artery disease, cardiovascular, ethnicity, pathogenesis, atherosclerosis, sudden cardiac death

    Lab Website

    Principal Investigator

    Wendy Post, M.D., M.S.

    Department

    Medicine

  • Qian Li Lab

    The Qian Li Lab's primary area of statistical expertise is the development and application of statistical methods for: (1) handling the truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (2) missing data, including outcome (e.g., frailty) censoring by a competing risk (e.g., mortality) and (3) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models.

    Research Areas: epidemiology, outcomes, biostatistics

    Principal Investigator

    Qian Li, M.S., Ph.D.

    Department

    Medicine

  • Qian-Li Xue Lab

    The primary area of statistical expertise in the Qian-Li Xue Lab is the development and application of statistical methods for: (1) handling the truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (2) missing data, including outcome (e.g., frailty) censoring by a competing risk (e.g., mortality) and (3) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models. In Women's Health and Aging Studies, we have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time.

    Research Areas: epidemiology, disabilities, longitudinal data, hormonal dysregulation, women's health, inflammation, frailty, biostatistics, gerontology, latent variables

    Principal Investigator

    Qian-Li Xue, Ph.D.

    Department

    Medicine

  • Rakhi Naik Lab

    The Rakhi Naik Lab studies sickle cell disease. We focus on complications related to the disease, including chronic kidney disease and venous thromboembolism. By defining the risks and factors for diseases related to the sickle cell trait, we hope to improve genetic counseling and screening and treatment recommendations. Other research in the lab examines the epidemiology and unique mechanisms of thrombosis in patients with hemoglobin disorders. Specifically, we are trying to identify mechanisms of hypercoagulability and develop treatments for patients with hemoglobinopathies.

    Research Areas: epidemiology, sickle cell diseases, kidney diseases, venous thromboembolism, hemoglobin disorders, genetic counseling

    Principal Investigator

    Rakhi Naik, M.D., M.H.S.

    Department

    Medicine

  • Raymond Reid Lab

    Research in the Raymond Reid Lab focuses on community health and pediatric infectious diseases among Native American populations; epidemiologic studies of enteric infections, Haemophilus influenzae, and pneumococcus; and field testing of vaccines and treatments.

    Research Areas: epidemiology, community health, vaccines, infectious disease, enteric infections

    Principal Investigator

    Raymond Reid, M.D.

    Department

    Medicine

  • Richard Chaisson Lab

    Research in the Richard Chaisson Lab primarily examines tuberculosis and HIV infection, with specific focus on global epidemiology, clinical trials, diagnostics and public health interventions. Our recent research has involved evaluating a molecular diagnostic test for tuberculosis in HIV patients; observing TB responses during treatment of pulmonary tuberculosis; and examining antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa.

    Research Areas: global health, epidemiology, infectious disease, AIDS, HIV, tuberculosis

    Principal Investigator

    Richard Chaisson, M.D.

    Department

    Medicine

  • Richard Moore Lab

    Research interests in the Richard Moore Lab include clinical epidemiology, costs, cost-effectiveness and outcomes of HIV/AIDS. We recently examined whether the effect of delaying antiretroviral therapy initiation in HIV-positive adults is modified by age at entry into care.

    Research Areas: epidemiology, antiretroviral therapies, AIDS, HIV

    Principal Investigator

    Richard Moore, M.D.

    Department

    Medicine

  • Robert Wise Lab

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD). We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma.

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD

    Principal Investigator

    Robert Wise, M.D.

    Department

    Medicine

  • Sara Cosgrove Lab

    The Sara Cosgrove Lab researches how infections with antibiotic-resistant bacteria affect patients. We are interested in the methods needed to make sure patients receive the best possible antibiotic treatment, including the development of tools and programs to promote the rational use of antimicrobials. We also study the epidemiology and management of S. aureus bacteremia.

    Research Areas: epidemiology, antimicrobials, antibiotics, resistant organisms

    Principal Investigator

    Sara Cosgrove, M.D.

    Department

    Medicine

  • Sevil Yasar Lab

    Research areas in the Sevil Yasar Lab include dementia, cognitive decline, hydrocephalus and pharmacoepidemiology. Recently, we studied the ability of fatty acid amide hydrolase (FAAH) inhibitors to block the rewarding effects of nicotine in squirrel monkeys.

    Research Areas: cognition, epidemiology, pharmacoepidemiology, dementia, gerontology, hydrocephalus

    Principal Investigator

    Sevil Yasar, M.D., Ph.D.

    Department

    Medicine

  • Sherita Golden Lab

    Research in the Sherita Golden Lab focuses on identifying endocrine risk factors associated with the development of diabetes and cardiovascular disease. We conduct our research by incorporating measures of hormonal function into the design of clinical trials of cardiovascular risk modification, observational studies of incident cardiovascular disease and diabetes, and studies evaluating diabetic complications.

    Research Areas: epidemiology, stress, hormones, diabetes, cardiovascular diseases, endocrinology

    Principal Investigator

    Sherita Golden, M.D., M.H.S.

    Department

    Medicine

  • Stephen Sozio Lab

    Researchers in the Stephen Sozio Lab study chronic kidney disease epidemiology, determine risk factors for stroke and cognitive impairment in patients with kidney disease, and perform comparative effectiveness research in patients with ESRD.

    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke

    Principal Investigator

    Stephen Sozio, M.D.

    Department

    Medicine

  • Susan Hutfless Lab

    The Susan Hutfless Lab uses administrative data to investigate epidemiologic questions about the causes of and treatments for chronic diseases, with a focus on gastrointestinal disorders. Our team has provided epidemiologic expertise to help design and analyze large-dataset studies of cervical cancer, colorectal cancer and mortality related to inflammatory bowel disease (IBD). We also have conducted research on infection-related triggers of Crohn’s disease in susceptible military personnel as well as prenatal and childhood predictors of pediatric-onset IBD.

    Research Areas: inflammatory bowel disease, Crohn’s disease, epidemiology, data analysis, maternal health, chronic disease, gastrointestinal

    Principal Investigator

    Susan Hutfless, Ph.D., S.M.

    Department

    Medicine

  • Thomas Quinn Lab

    Research in the Thomas Quinn Lab encompasses epidemiology, pathogenesis and clinical features of HIV/AIDS internationally, which includes the interaction between STDs and tropical diseases on the natural history and spread of HIV/AIDS in developing countries. Our recent research has examined the viral kinetics and transmission probabilities of HIV among discordant couples with the subsequent design and application of interventions, including therapy to prevent transmission of HIV. Molecular studies have mapped the molecular epidemic of HIV on a global basis, linking virologic changes to the spread of HIV and measuring the demographic impact of the epidemic.

    Research Areas: epidemiology, infectious disease, AIDS, HIV, sexually transmitted diseases, pathogenesis

    Principal Investigator

    Thomas Quinn, M.D.

    Department

    Medicine

  • Virginia Weaver Lab

    The Virginia Weaver Lab uses molecular epidemiology tools to evaluate chemically exposed populations. We explore the validation of exposure and early biological effect markers for research and medical surveillance. Our primary research area is the effects of occupational and environmental toxicants on the kidney. We are currently investigating how metals affect kidney function, examining in particular clinical measures and early biological effect markers, including urinary N-acetyl-beta-D-glucosaminidase. Our studies have involved populations of lead workers in South Korea and environmentally exposed adolescents in Mexico.

    Research Areas: medical surveillance, global health, epidemiology, biomarkers, kidney diseases, environment

    Principal Investigator

    Virginia Weaver, M.D., M.P.H.

    Department

    Medicine

  • William Checkley Lab

    Research in the William Checkley Lab explores the field of lung health, with an emphasis on the epidemiology of obstructive lung diseases as well as acute lung injury and mechanical ventilation. We also explore the interactions between nutrition and infection, and the impact of environmental exposures to health.

    Research Areas: critical care medicine, epidemiology, international lung health, mechanical ventilation, acute lung injury, lung disease

    Lab Website

    Principal Investigator

    William Checkley, M.D., Ph.D.

    Department

    Medicine

  • Zackary Berger Lab

    The research mission of the Zackary Berger Lab is to bridge evidence-based medicine and shared decision-making in the context of patient-centered care. Lab studies investigate how to accomplish this in the common case of uncertainty, while seeking to clarify the ethics of decision-making and empirically describe how shared decision-making is and should be done.

    Zackary Berger, MD, PhD, is an assistant professor in the Division of General Internal Medicine at the Johns Hopkins School of Medicine. In addition to his work as an internist and primary care physician, Dr. Berger is an associate faculty member in the Berman Institute of Bioethics, and core faculty in the Evidence Based Practice Center as well as the Center for Health Services and Outcomes Research.

    Research Areas: epidemiology, patient-centered health care, evidence-based medicine, bioethics

    Principal Investigator

    Zackary Berger, M.D., Ph.D.

    Department

    Medicine

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