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The Lima Lab’s research is concentrated on the development and application of imaging and technology to address scientific and clinical problems involving the heart and vascular system.
Specifically, our research is focused on developing magnetic resonance imaging (MRI) contrast techniques to investigate microvascular function in patients and experimental animals with myocardial infarction; functional reserve secondary to dobutamine stimulation and myocardial viability assessed by sodium imaging; and cardiac MRI and computed tomography (CT) program development of techniques to characterize atherosclerosis in humans with cardiovascular or cerebrovascular disease.
Current projects include:
• The Coronary Artery Risk Development in Young Adults (CARDIA) Study
• The MESA (Multi-Ethnic Study of Atherosclerosis) Study
• The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) Study
Joao Lima, MD, is a professor of medicine, radiology and... epidemiology at the Johns Hopkins School of Medicine. view less
The Lisa Cooper Lab is dedicated to researching patient-centered interventions for improving health outcomes and overcoming racial and ethnic disparities in health care. Our primary focus is on the factors of physician communication skills and cultural competence training, patient shared decision-making and self-management skills training. Recently, we have explored patient-centered depression care for African Americans, tactics for improving patient-physician communication about management of hypertension, and reducing ethnic and social disparities in health. In addition, we are currently researching racial disparities in cardiovascular health outcomes for patients living in Baltimore.
Lisa Maragakis Lab
Researchers in the Lisa Maragakis Lab are interested in health care-acquired infections and antimicrobial-resistant Gram-negative bacilli. We are particularly interested in the epidemiology, prevention and management of these infections.
Margaret Daniele Fallin Lab
Work in the Margaret Daniele Fallin Lab focuses on the genetic epidemiology of neuropsychiatric conditions. Our team primarily studies the genetic basis of autism spectrum disorder, Alzheimer’s disease, schizophrenia and bipolar disorder. We also explore the integration of genetic susceptibility and environmental risk. Our current research involves applying genetic epidemiology methods to develop applications and methods for epigenetic epidemiology, with a focus on mental health and development.
Mark Jennings Lab
The Mark Jennings Lab conducts research on bacterial infection in patients with cystic fibrosis. We are currently conducting a clinical trial to investigate the epidemiology and treatment of small-colony variant staphylococcus aureus in cystic fibrosis. We’ve also recently studied eradication strategies for persistent methicillin-resistant staphylococcus aureus infection in patients with cystic fibrosis.
Michael Klag Lab
The Michael Klag Lab focuses on the epidemiology and prevention of kidney disease, cardiovascular disease and hypertension. Our research determined that the U.S. was experiencing an epidemic of end-stage kidney disease, pinpointed the incidence of kidney disease and published scholarship on risk factors for kidney disease such as race, diabetes and socioeconomic status. Our Precursors Study has shown that serum cholesterol measured at age 22 years is a predictor for midlife cardiovascular disease, a finding that has influenced policy about cholesterol screening in young adults. We also research health behaviors that lead to hypertension and study how differences in these behaviors affect urban and non-urban populations.
Nae-Yuh Wang Lab
The Nae-Yuh Wang Lab concentrates on a wide range of multicenter studies and randomized controlled trials. Recent studies have focused on pediatric cochlear implantation and longitudinal data analysis. One recent study found that partnering with primary care providers to deliver weight loss programs may promote greater participant satisfaction and weight loss. Another active study is assessing the effectiveness of promising interventions to reduce race disparities in live donor kidney transplantation.
Naresh Punjabi Lab
The Naresh Punjabi Lab primarily studies sleep apnea, epidemiology, cardiovascular disease, insulin resistance and type 2 diabetes. Our current research focuses on the epidemiology of sleep apnea with a particular emphasis on associated sequelae, including insulin resistance, type 2 diabetes mellitus and cardiovascular disease. We have been part of the multi-center Sleep Heart Health Study, an epidemiological study on the longitudinal effects of sleep apnea on hypertension, cardiovascular disease and mortality. Our lab is examining the independent effects of intermittent hypoxia on various pathways to help elucidate the links between sleep apnea, insulin resistance and metabolic dysfunction.
Patrick Breysse Lab
Research in the Patrick Breysse Lab seeks to better understand the biological, chemical and physical factors that can impact a patient’s health. Our team is currently studying the effects of indoor and outdoor air pollution on childhood asthma, respiratory tract infections, chronic obstructive pulmonary disease (COPD) and other respiratory conditions. We also conduct research on secondhand smoke exposure around the world and have participated in a range of health and exposure studies in Peru, Nepal, Mongolia, Columbia and India.
The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative study of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.
As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.
Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coron...ary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.
Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.
Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine. view less