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Displaying 21 to 24 of 24 results for environment

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  • Shyam Sundar Biswal Lab

    xResearch in the Shyam Biswal Lab focuses on therapeutic resistance of cancer due to a gain-of-function mutation in transcription factor Nrf2. Using patient-derived xenografts in humanized immunocompetent mice and GEM models, we aim to understand the mechanisms of oncogenic cooperation and metabolic adaptation in cancer cells. We’re also investigating the systemic and pulmonary effects of air pollution as well as the health effects of recent tobacco products, such as electronic cigarettes and water pipes.

    Research Areas: Nrf2, tobacco use, genetics, cancer, pulmonary medicine, environment, lung cancer

    Principal Investigator

    Shyam Biswal, Ph.D.

    Department

    Medicine

  • Stivers Lab

    The Stivers Lab is broadly interested in the biology of the RNA base uracil when it is present in DNA. Our work involves structural and biophysical studies of uracil recognition by DNA repair enzymes, the central role of uracil in adapative and innate immunity, and the function of uracil in antifolate and fluoropyrimidine chemotherapy. We use a wide breadth of structural, chemical, genetic and biophysical approaches that provide a fundamental understanding of molecular function. Our long-range goal is to use this understanding to design novel small molecules that alter biological pathways within a cellular environment. One approach we are developing is the high-throughput synthesis and screening of small molecule libraries directed at important targets in cancer and HIV-1 pathogenesis.

    Research Areas: biophysics, enzymes, cell biology, uracil, cancer, HIV, DNA, RNA

  • Virginia Weaver Lab

    The Virginia Weaver Lab uses molecular epidemiology tools to evaluate chemically exposed populations. We explore the validation of exposure and early biological effect markers for research and medical surveillance. Our primary research area is the effects of occupational and environmental toxicants on the kidney. We are currently investigating how metals affect kidney function, examining in particular clinical measures and early biological effect markers, including urinary N-acetyl-beta-D-glucosaminidase. Our studies have involved populations of lead workers in South Korea and environmentally exposed adolescents in Mexico.

    Research Areas: medical surveillance, global health, epidemiology, biomarkers, kidney diseases, environment

    Principal Investigator

    Virginia Weaver, M.D., M.P.H.

    Department

    Medicine

  • Zaver M. Bhujwalla Lab – Cancer Imaging Research

    Dr. Bhujwalla’s lab promotes preclinical and clinical multimodal imaging applications to understand and effectively treat cancer. The lab’s work is dedicated to the applications of molecular imaging to understand cancer and the tumor environment. Significant research contributions include 1) developing ‘theranostic agents’ for image-guided targeting of cancer, including effective delivery of siRNA in combination with a prodrug enzyme 2) understanding the role of inflammation and cyclooxygenase-2 (COX-2) in cancer using molecular and functional imaging 3) developing noninvasive imaging techniques to detect COX-2 expressing in tumors 4) understanding the role of hypoxia and choline pathways to reduce the stem-like breast cancer cell burden in tumors 5) using molecular and functional imaging to understand the role of the tumor microenvironment including the extracellular matrix, hypoxia, vascularization, and choline phospholipid metabolism in prostate and breast cancer invasion and metast...asis, with the ultimate goal of preventing cancer metastasis and 6) molecular and functional imaging characterization of cancer-induced cachexia to understand the cachexia-cascade and identify novel targets in the treatment of this condition. view more

    Research Areas: molecular and functional imaging, preventing cancer metastasis, metastasis, image-guided targeting of cancer, cancer-induced cachexia, cancer imaging

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