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Research Lab Results for diabetes

Displaying 11 to 20 of 31 results
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  • Jodi Segal Lab

    Principal Investigator:
    Jodi Segal, M.D., M.P.H.
    Medicine

    Research in the Jodi Segal Lab focuses on developing methodologies to use observational data to understand the use of new drugs, particularly drugs for treating diabetes, blood disorders and osteoporosis. We apply advanced methods for evidence-based review and meta-analysis, and—in collaboration with Johns Hopkins biostatisticians—we have developed new methodologies for observational research (using propensity scores to adjust for covariates that change over time) and methods to account for competing risks and heterogeneity of treatment effects in analyses.

    Research Areas: blood disorders, osteoporosis, diabetes, drugs, evidence-based medicine
  • Katherine Wilson Lab

    Principal Investigator:
    Katherine Wilson, Ph.D.
    Cell Biology

    Research in the Wilson Lab focuses on three components of nuclear lamina structure: lamins, LEM-domain proteins (emerin), and BAF.

    These three proteins all bind each other directly, and are collectively required to organize and regulate chromatin, efficiently segregate chromosomes and rebuild nuclear structure after mitosis. Mutations in one or more of these proteins cause a variety of diseases including Emery-Dreifuss muscular dystrophy (EDMD), cardiomyopathy, lipodystrophy and diabetes, and accelerated aging.

    We are examining emerin's role in mechanotransduction, how emerin and lamin A are regulated, and whether misregulation contributes to disease.

    Research Areas: cell biology, Emery-Dreifuss muscular dystrophy (EDMD), accelerated aging, chromatin, diabetes, genomics, emerin, nuclear lamina, lipodystrophy, cardiomyopathy
  • Kendall Moseley Lab

    Principal Investigator:
    Kendall Moseley, M.D.
    Medicine

    Research in the Kendall Moseley Lab is focused on the interplay between type 2 diabetes, aging and osteoporosis. We also study the function of bone stem cells in the regulation of bone remodeling.

    Research Areas: type 2 diabetes, osteoporosis, stem cells, aging
  • Lee Bone Lab

    Principal Investigator:
    Lee Bone, M.P.H.
    Medicine

    Research in the Lee Bone Lab uses community-based participatory approaches to promote health in underserved urban African-American populations. We conduct randomized clinical trials on cardiovascular disease, diabetes and cancer detection and control in order to test the success of community interventions. We focus in particular on making interventions sustainable and on implementing electronic education to improve communication.

    Research Areas: African Americans, cancer, diabetes, community outreach, cardiovascular diseases, community health education
  • Mark Sulkowski Lab

    Lab Website
    Principal Investigator:
    Mark Sulkowski, M.D.
    Medicine

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clinical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group.

    Research Areas: infectious disease, hepatitis B, hepatitis C
  • Michael Klag Lab

    Principal Investigator:
    Michael Klag, M.D., M.P.H.
    Medicine

    The Michael Klag Lab focuses on the epidemiology and prevention of kidney disease, cardiovascular disease and hypertension. Our research determined that the U.S. was experiencing an epidemic of end-stage kidney disease, pinpointed the incidence of kidney disease and published scholarship on risk factors for kidney disease such as race, diabetes and socioeconomic status. Our Precursors Study has shown that serum cholesterol measured at age 22 years is a predictor for midlife cardiovascular disease, a finding that has influenced policy about cholesterol screening in young adults. We also research health behaviors that lead to hypertension and study how differences in these behaviors affect urban and non-urban populations.

    Research Areas: longitudinal data, kidney diseases, health behaviors, hypertension, cardiovascular diseases, cholesterol
  • Michael Matunis Lab

    Principal Investigator:
    Michael Matunis, Ph.D.
    Cell Biology

    Research in the Michael Matunis Lab focuses on the SUMO family of small ubiquitin-related proteins. We study the covalent conjugation of SUMOs to other cellular proteins, which regulates numerous processes needed for cell growth and differentiation, and which, when defective, can lead to conditions such as cancer, neurodegenerative disease and diabetes.

    Research Areas: SUMO proteins, neurodegenerative diseases, cellular biology, proteomics, cancer, diabetes, malaria
  • Michael Wolfgang Laboratory

    The Wolfgang Laboratory is interested in understanding the metabolic properties of neurons and glia at a mechanistic level in situ. Some of the most interesting, enigmatic and understudied cells in metabolic biochemistry are those of the nervous system. Defects in these pathways can lead to devastating neurological disease. Conversely, altering the metabolic properties of the nervous system can have surprisingly beneficial effects on the progression of some diseases. However, the mechanisms of these interactions are largely unknown.

    We use biochemical and molecular genetic techniques to study the molecular mechanisms that the nervous system uses to sense and respond to metabolic cues. We seek to understand the neurometabolic regulation of behavior and physiology in obesity, diabetes and neurological disease.

    Current areas of study include deconstructing neurometabolic pathways to understand the biochemistry of the nervous system and how these metabolic pathways impact animal beh...avior and physiology, metabolic heterogeneity and the evolution of metabolic adaptation. view more

    Research Areas: metabolic biochemistry, obesity, diabetes, genomics, neurology, nervous system, molecular biology
  • Mihail Zilbermint Lab

    Principal Investigator:
    Mihail Zilbermint, M.D.
    Medicine

    Research in the Mihail Zilbermint Lab focuses on diabetes, adrenal disease and thyroid disease. Recent areas of focus include pseudohypoaldosteronism type 1 related to novel variants of SCNN1B gene, genetic variance in the ARMC5 gene in primary macronodular adrenocortical hyperplasia and hyperaldosteronism due to de novo KCNJ5 mutation.

    Research Areas: hypoaldosteronism, genetics, tumor, diabetes, hyperplasia, protein kinases
  • Nestoras Mathioudakis Lab

    Lab Website

    The Nestoras Mathioudakis Lab focuses on improving patient safety and quality for hospitalized diabetes patients. Our interests include inpatient glucose management, type 2 diabetes mellitus and diabetic foot ulcers.

    Research Areas: glucose management, health care quality, safety, diabetes, diabetic foot ulcers
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