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• Aniket Sidhaye Lab

  Dr. Sidhaye is interested in improving the care of persons with cystic fibrosis, type 1 diabetes mellitus and hospitalized person with diabetes. research topics include bone health of persons with CF undergoing lung transplant, CF-related diabetes mellitus, Care of persons with type 1 diabetes mellitus transitioning from pediatrics to adult specialty clinics, Management of hospitalized persons with diabetes.

  Research Areas: biochemistry, obesity, hormones, diabetes, transitional care, endocrinology, thyroid

  Lab Website

  

  Principal Investigator

  Aniket Sidhaye, M.D.

  Department

  Medicine
  

• Christian Merlo Lab

  Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients.

  Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

  

  Principal Investigator

  Christian Merlo, M.D., M.P.H.

  Department

  Medicine
  

• Kristin Riekert Lab

  Work in the Kristin Riekert Lab focuses on methods for improving health care quality and delivery, particularly among underserved and disadvantaged populations. Our research covers a range of important topics, including health beliefs, treatment adherence, doctor-patient communication, self-management interventions, mobile health initiatives, health disparities and patient-reported outcome methodology. We also work with the National Institutes of Health on multiple intervention trials focused on improving adherence and health outcomes in asthma, chronic kidney disease, cystic fibrosis (CF), sickle cell disease and secondhand smoke reduction.

  Research Areas: health care quality, treatment adherence, cystic fibrosis, patient-provider relationships, chronic illnesses, health disparities

  

  Principal Investigator

  Kristin Riekert, Ph.D.

  Department

  Medicine
  

• Liudmila Cebotaru Lab

  Research in the Liudmila Cebotaru Lab studies cystic fibrosis transmembrane conductance regulator (CFTR) mutants. We also investigate corrector molecules that are currently in clinical trials to get a better understanding of their mechanism of action. A major focus of our research is on developing more efficient gene therapy vectors with the ultimate goal of developing a gene therapy for cystic fibrosis.

  Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, corrector molecules

  

  Principal Investigator

  Liudmila Cebotaru, J.D., M.D.

  Department

  Medicine
  

• Michelle Eakin Lab

  The Michelle Eakin Lab conducts research on behavioral science and adherence and asthma outcomes in inner-city children. Our studies into behavioral science have included exploring the impact of medication adherence on lung health outcomes in patients with cystic fibrosis, disparities in anti-hypertensive medication adherence in adolescents and other key topics. We also investigate methods for improving asthma care and treatment as well as health disparities among various ethnicities, particularly in pediatric patients.

  Research Areas: cystic fibrosis, asthma, behavioral medicine, health disparities

  

  Principal Investigator

  Michelle Eakin, M.A., Ph.D.

  Department

  Medicine
  

• Natalie West Lab

  The Natalie West Lab collaborates with Noah Lechtzin’s lab to study cystic fibrosis, with a particular focus on new resistant bacteria and their effect on the lung function of people with cystic fibrosis.

  Research Areas: microbiology, cystic fibrosis, resistant organisms

  Lab Website

  

  Principal Investigator

  Natalie West, M.D., M.H.S.

  Department

  Medicine
  

• Noah Lechtzin Lab

  Research in the Noah Lechtzin Lab investigates several important aspects of cystic fibrosis (CF), including the impact of antibiotic-resistant bacterial infections in CF patients and new therapy options for individuals with CF. Our research into new CF therapies has included studies on home electronic symptom and lung function monitoring, transbronchial needle aspiration and bedside percutaneous endoscopic gastrostomy tube placement. We also explore the role of metabolic complications in CF patients by examining how the disease is impacted by factors such as vitamin D deficiency, osteoporosis and testosterone deficiency.

  Research Areas: osteoporosis, cystic fibrosis, pulmonary medicine, metabolism, antibiotic-resistant bacterial infections, testosterone

  

  Principal Investigator

  Noah Lechtzin, M.D., M.H.S.

  Department

  Medicine
  

• William B. Guggino Lab

  Work in the William B. Guggino Lab focuses on the structure of the cystic fibrosis transmembrane conductance regulator (CFTR) and water channels; the molecular structure of transport proteins in epithelial cell membranes; and gene therapies to treat cystic fibrosis (CF) patients. We are also working to identify CF’s specific defect in chloride channel regulation. One recent study showed that insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR.

  Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, ion channels

  Lab Website

  

  Principal Investigator

  William Guggino, Ph.D.

  Department

  Physiology
  

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