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• Charles Hugh Brown Lab

  The Charles Hugh Brown Lab researches cognitive dysfunction, with a focus on quality of care and outcomes regarding perioperative management of older patients. Our studies explore post-operative delirium, cognitive changes and transfusion practices. We also have a longstanding interest in cerebral autoregulation and its role in post-surgical outcomes.

  Research Areas: critical care medicine, cognitive dysfunction, post-operative delirium, post-surgical outcomes, cerebral autoregulation

  

  Principal Investigator

  Charles Brown, M.D.

  Department

  Anesthesiology and Critical Care Medicine
  

• Courtney Robertson Lab

  Work in the Courtney Robertson Lab is focused on identifying interventions that could minimize the neurological deficits that can persist after pediatric traumatic brain injury (TBI). One study used a preclinical model to examine potential disruption of mitochondrial function and alterations in cerebral metabolism. It was found that a substantial amount of mitochondrial dysfunction is present in the first six hours after TBI. In addition, we are using nuclear magnetic resonance spectroscopy to evaluate global and regional alterations in brain metabolism after TBI. We're also collaborating with researchers at the University of Pennsylvania to compare mitochondrial function after head injury in different clinically relevant models.

  Research Areas: traumatic brain injuries, magnetic resonance spectroscopy, pediatrics, mitochondria, pediatric critical care medicine

  Lab Website

  

  Principal Investigator

  Courtney Robertson, M.D.

  Department

  Anesthesiology and Critical Care Medicine
  

• David Hager Lab

  Research in the David Hager Lab focuses on critical care medicine. Recent studies includes an analysis of advances in the management of the acute respiratory distress syndrome (ARDS) and the development of a targeted real-time early warning score predicting septic shock. Other interests include ventilator-induced lung injury and high-frequency ventilation.

  Research Areas: critical care medicine, acute respiratory distress syndrome, high-frequency ventilation, ventilator-induced lung injury

  

  Principal Investigator

  David Hager, M.D., Ph.D.

  Department

  Medicine
  

• Donald Shaffner Lab

  Work in the Donald Shaffner Lab investigates several topics within critical care medicine. Our team conducts research on the mechanisms involved in neurologic injury from global ischemia as a result of cardiac arrest and resuscitation. We also study neurologic outcomes of pediatric patients who experience cardiac arrest.

  Research Areas: hyperthermia, critical care medicine, cardiac arrest, resuscitation, ischemia, pediatrics, neurology

  

  Principal Investigator

  Donald Shaffner, M.D.

  Department

  Anesthesiology and Critical Care Medicine
  

• Elizabeth Daugherty Lab

  The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection control and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence.

  Research Areas: critical care medicine, patient safety, infection control, nosocomial infections

  

  Principal Investigator

  Elizabeth Daugherty, M.D., M.P.H.

  Department

  Medicine
  

• Enid Neptune Lab

  Work in the Enid Neptune Lab focuses on topics within the fields of pulmonary and critical care medicine. Our research centers primarily on therapeutic strategies for Marfan syndrome and hepatocyte growth factor signaling in airspace homeostasis. We also conduct research on chronic obstructive pulmonary disease (COPD), with a focus on its mechanisms and potential methods for preventing its progression. Our research within critical care has most recently involved investigating superoxide dismutase 3 dysregulation in neonatal lung injuries.

  Research Areas: critical care medicine, pulmonary medicine, COPD, Marfan syndrome

  

  Principal Investigator

  Enid Neptune, M.D.

  Department

  Medicine
  

• Franco D’Alessio Lab

  The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

  Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

  

  Principal Investigator

  Franco D'Alessio, M.D.

  Department

  Medicine
  

• Ivor Berkowitz Lab

  Research in the Ivor Berkowitz Lab targets pediatric critical care medicine. We are particularly interested in the pathophysiology behind the cerebrovascular dysfunction that occurs in bacterial meningitis as well as the anesthetic and perioperative complications of patients with dwarfing syndromes.

  Research Areas: cerebrovascular dysfunction, bacterial meningitis, dwarfing syndromes, pediatric critical care medicine

  

  Principal Investigator

  Ivor Berkowitz, M.B.B.Ch.

  Department

  Anesthesiology and Critical Care Medicine
  

• John McCloskey Lab

  Research in the John McCloskey Lab focuses on quality improvements in the operating room and pediatric intensive care unit (PICU). Our work aims to improve the throughput of adolescents undergoing spinal fusions in order to better define interventions to ameliorate anesthesia emergence delirium and to improve protocols for sedation. One of our projects established an early oral feeding program for critically ill patients. Our goal is to enhance the delivery and quality of children’s health care while making it safer and more affordable.

  Research Areas: patient safety, patient outcomes, anesthesia, delirium, sedation, intensive care, pediatric critical care medicine

  Lab Website

  

  Principal Investigator

  John McCloskey, M.D.

  Department

  Anesthesiology and Critical Care Medicine
  

• Jonathan Jun Lab

  The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

  Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

  Lab Website

  

  Principal Investigator

  Jonathan Jun, M.D.

  Department

  Medicine
  

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