Research Lab Results for colorectal cancer
Brindusa Truta LabPrincipal Investigator:
Brindusa Truta, M.D., M.A.S.
The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ul...cerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history. view moreResearch Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis
Franck Housseau LabPrincipal Investigator:
Franck Housseau, Ph.D.
The Franck Housseau Lab focuses on the role of the microbiome in colorectal tumorigenesis and o...n developing a better understanding of the tumor immune microenvironment. The lab is currently working to define the biomarkers of a pre-existing antitumor immune response in metastatic colorectal cancer to define a population of patients eligible for checkpoint blockade therapies. view moreResearch Areas: microbiology, tumor immunology, microbiome, colorectal cancer, cancer, colon cancer, tumor microenvironment, immunotherapy
Lei Zheng LabLab WebsitePrincipal Investigator:
Lei Zheng, M.D., Ph.D.
Zheng’s research focuses on two R01-funded projects; first, the group has developed a pancreati...c cancer immunotherapy research program on a neoadjuvant therapy platform as well as a number of preclinical models of pancreatic cancer for developing innovative immunotherapy strategies. The group has applied the knowledge gained from pancreatic cancer immune-based therapies to the development of a colorectal cancer GVAX vaccine. Second, the group is aimed at understanding the mechanistic roles of the tumor microenvironment in cancer development and metastasis and identifying new targets for pancreatic cancer therapies by dissecting the tumor microenvironment of pancreatic cancer. view moreResearch Areas: cancer, pancreatic cancer, translational research, tumor microenvironment, immunotherapy
Linda Smith-Resar LabLab WebsitePrincipal Investigator:
Linda Smith Resar, M.D.
The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanism...s that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention. view moreResearch Areas: blood disorders, sickle cell diseases, blood management programs, hematologic malignancies
Reezwana Chowdhury LabPrincipal Investigator:
Reezwana Chowdhury, M.D.
The Reezwana Chowdhury Lab performs clinical research on Inflammatory Bowel Disorder and colore...ctal cancer. view moreResearch Areas: Inflammatory Bowel Disorder, colorectal cancer