The James Potter Lab studies the effect of ethanol and its metabolites on the a2(I) and a1(I) collagen promoters; the role of leptin on fibrogenesis; the role of Kupffer cells, cytokines, retinoic acid and leptin in stellate cell tansdifferentiation and collagen production; hormonal regulation of rat class I alcohol dehydrogenase; and transcriptional regulation of rat class I alcohol dehydrogenase promotor.
The Glunde lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The lab is developing mass spectrometry imaging as part of multimodal molecular imaging workflows to image and elucidate hypoxia-driven signaling pathways in breast cancer. They are working to further unravel the molecular basis of the aberrant choline phospholipid metabolism in cancer. The Glunde lab is developing novel optical imaging agents for multi-scale molecular imaging of lysosomes in breast tumors and discovering structural changes in Collagen I matrices and their role in breast cancer and metastasis.