Skip Navigation

Find a Research Lab

Research Lab Results for clinical trials

Displaying 21 to 38 of 38 results
Results per page:
  • Kawsar Rasmy Talaat Lab

    Principal Investigator:
    Kawsar Talaat, M.D.
    Medicine

    Research in the Kawsar Rasmy Talaat Lab focuses on international health and parasitology, with ...an emphasis on vaccines, avian influenza and pandemic influenza. Our team conducts clinical trials of vaccines for a range of diverse pathogens, including flu strains that have the potential to reach pandemic status. Our studies seek to evaluate the safety and immunogenicity of vaccine candidates. We also have a longstanding interest in tropical medicine. view more

    Research Areas: international health, vaccines, infectious disease, flu
  • Kayode Williams Lab

    The Kayode Williams Lab conducts translational research on neuromodulation. We primarily examin...e the mechanisms and efficacy of spinal cord stimulation in treating neuropathic pain, peripheral neuropathies and peripheral vascular disease. Our clinical trials explore spinal cord stimulation in the treatment of painful diabetic neuropathy and the treatment of critical non-reconstructible critical leg ischemia. We also have a longstanding interest in the business of medicine and seek to enhance value propositions for hospitals and physician groups through more effective management of resources. view more

    Research Areas: pain management, neuropathic pain, translational research, vascular diseases
  • Kelly E. Dooley Laboratory

    Lab Website

    Research focuses on clinical pharmacology of new anti-tuberculosis regimens with an emphasis on...: (1) Phase I clinical trials of new or existing anti-TB drugs including dose escalation trials and studies of drug-drug interactions between anti-TB agents and antiretrovirals to treat HIV; (2) Use of PK/PD analysis and modelling in Phase II tuberculosis clinical treatment trials to determine concentration-effect relationships that will allow for optimization of dosing; and (3) Evaluation of TB and HIV drug concentrations in special populations, such as pregnant women and children; (4) Evaluation of treatment-shortening regimens for drug-sensitive TB and investigational regimens for treatment of multidrug-resistant TB; and (5) Translational work involving novel animal models of cavitary pulmonary TB disease to understand drug distribution in diseased lung. view more

    Research Areas: anti-infective drugs, antiretroviral therapies, tuberculosis and HIV treatments, HIV, lung disease, pharmacology, tuberculosis
  • Laura Hummers Lab

    Lab Website
    Principal Investigator:
    Laura Hummers, M.D.
    Medicine

    The Laura Hummers Lab participates in a number of clinical trials and clinical investigations a...t the Scleroderma Center at Johns Hopkins. We have a particular interest in the predictors of outcomes in scleroderma. We’ve established a prospective cohort of 300 scleroderma patients to identify incident vascular outcomes in the hopes of identifying new biomarkers for disease development and progression. view more

    Research Areas: rheumatology, biomarkers, scleroderma
  • Liudmila Cebotaru Lab

    Research in the Liudmila Cebotaru Lab studies cystic fibrosis transmembrane conductance regulat...or (CFTR) mutants. We also investigate corrector molecules that are currently in clinical trials to get a better understanding of their mechanism of action. A major focus of our research is on developing more efficient gene therapy vectors with the ultimate goal of developing a gene therapy for cystic fibrosis. view more

    Research Areas: cell biology, cystic fibrosis, kidney diseases, gene therapy, corrector molecules
  • Marek Mirski Lab

    Lab Website

    Work in the Marek Mirski lab explores the subcortical mechanisms of seizure propagation and cor...tical synchrony. The primary goal of our research is to develop methodologies for inhibiting seizures using site-specific subcortical electrical stimulation. Our identification of synaptically linked subcortical elements that contribute to seizure propagation has led to FDA-sanctioned phase III clinical trials to assess the use of targeted thalamic stimulation in patients with intractable seizures. We also conduct clinical research on the treatment of acute head injury, elevated intracranial pressure, cerebral edema, ischemic stroke and ICU sedation. view more

    Research Areas: edema, stroke, head injury, seizure, sedation
  • Mark Sulkowski Lab

    Lab Website
    Principal Investigator:
    Mark Sulkowski, M.D.
    Medicine

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clin...ical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group. view more

    Research Areas: infectious disease, hepatitis B, hepatitis C
  • Molecular Oncology Laboratory

    Principal Investigator:
    Valsamo Anagnostou, M.D., Ph.D.
    Oncology

    Our Molecular Oncology lab seeks to understand the genomic wiring of response and resistance to... immunotherapy through integrative genomic, transcriptomic, single-cell and liquid biopsy analyses of tumor and immune evolution. Through comprehensive exome-wide sequence and genome-wide structural genomic analyses we have discovered that tumor cells evade immune surveillance by elimination of immunogenic mutations and associated neoantigens through chromosomal deletions. Additionally, we have developed non-invasive molecular platforms that incorporate ultra-sensitive measurements of circulating cell-free tumor DNA (ctDNA) to assess clonal dynamics during immunotherapy. These approaches have revealed distinct dynamic ctDNA and T cell repertoire patterns of clinical response and resistance that are superior to radiographic response assessments. Our work has provided the foundation for a molecular response-adaptive clinical trial, where therapeutic decisions are made not based on imaging but based on molecular responses derived from liquid biopsies. Overall, our group focuses on studying the temporal and spatial order of the metastatic and immune cascade under the selective pressure of immune checkpoint blockade with the ultimate goal to translate this knowledge into “next-generation” clinical trials and change the way oncologists select patients for immunotherapy. view more

    Research Areas: integrative mutli-omic analyses, Cancer genomics, liquid biopsies, tumor evolution, lung cancer, immunogenomic biomarkers
  • Nicholas Rowan Lab

    Dr. Rowan is actively involved in both outcomes and translational research relating to chronic ...rhinosinusitis and endoscopic skull base surgery. He has a keen interest patient-reported quality of life outcomes as well as those that pertain to smell and taste. Dr. Rowan is also involved in sinus-related clinical trials, pursuing new medical therapies and technological advancements for the treatment of patients with chronic rhinosinusitis. view more

    Research Areas: clinical trials, smell and taste outcomes, Quality of life outcomes
  • Richard Chaisson Lab

    Principal Investigator:
    Richard Chaisson, M.D.
    Medicine

    Research in the Richard Chaisson Lab primarily examines tuberculosis and HIV infection, with sp...ecific focus on global epidemiology, clinical trials, diagnostics and public health interventions. Our recent research has involved evaluating a molecular diagnostic test for tuberculosis in HIV patients; observing TB responses during treatment of pulmonary tuberculosis; and examining antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. view more

    Research Areas: global health, epidemiology, infectious disease, AIDS, HIV, tuberculosis
  • Robert Wise Lab

    Principal Investigator:
    Robert Wise, M.D.
    Medicine

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view more

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD
  • Roy Brower Lab

    Principal Investigator:
    Roy Brower, M.D.
    Medicine

    The Roy Brower Lab conducts clinical trials related to the management of acute respiratory dist...ress syndrome (ARDS). Our research also involves oxygen toxicity, a potentially fatal condition caused by too much supplemental oxygen. view more

    Research Areas: acute respiratory distress syndrome, oxygen toxicity, acute lung injury
  • Saleh Alqahtani Lab

    Principal Investigator:
    Saleh Alqahtani, M.B.Ch.B., M.S.
    Medicine

    The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver diseas...e and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients. view more

    Research Areas: fatty liver disease, Hepatitis, hepatitis B, liver transplants, cirrhosis, Drug Induced Liver Injury, hepatitis C, liver diseases, liver cancer
  • Sherita Golden Lab

    Principal Investigator:
    Sherita Golden, M.D., M.H.S.
    Medicine

    Research in the Sherita Golden Lab focuses on identifying endocrine risk factors associated wit...h the development of diabetes and cardiovascular disease. We conduct our research by incorporating measures of hormonal function into the design of clinical trials of cardiovascular risk modification, observational studies of incident cardiovascular disease and diabetes, and studies evaluating diabetic complications. view more

    Research Areas: epidemiology, stress, hormones, diabetes, cardiovascular diseases, endocrinology
  • Spinal Column Surgical Outcomes Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Surgical Outcomes Laboratory aims to improve the neurological outcomes and fu...nctional capacity of patients undergoing spinal surgery. We collect large-scale retrospective patient databases and prospective patient registries to report high-quality data relating to the outcomes of neurosurgical operations. The laboratory participates in the National neurosurgical Quality and Outcomes Database (N2QOD). This multi-institutional collaboration has set forth a 3-year prospective study to benchmark quality and surgical outcome measures across several academic institutions. The Spinal Column Surgical Outcomes Laboratory specializes in biostatistical analysis of large-scale clinical databases, studying the outcomes of traditional and novel spinal procedures, quality control and cost-effectiveness research and clinical trials relating to spinal surgery outcomes. view more

    Research Areas: spine
  • Steven Levin Lab

    Lab Website

    Research in the Steven Levin Lab focuses on chemical neurolysis, epiduroscopy (and training for... physicians), opioid administration, and the use of alternative therapies for pain management. In collaboration with the American Society of Law, Medicine and Ethics and with funding from a Donahue Foundation Grant, we study social and ethical considerations in pain management. We have also been involved in clinical trials of novel analgesics. view more

    Research Areas: opioids, pain management, chemical neurolysis, epiduroscopy
  • Vestibular NeuroEngineering Lab

    Lab Website

    Research in the Vestibular NeuroEngineering Lab (VNEL) focuses on restoring inner ear function ...through “bionic” electrical stimulation, inner ear gene therapy, and enhancing the central nervous system’s ability to learn ways to use sensory input from a damaged inner ear. VNEL research involves basic and applied neurophysiology, biomedical engineering, clinical investigation and population-based epidemiologic studies. We employ techniques including single-unit electrophysiologic recording; histologic examination; 3-D video-oculography and magnetic scleral search coil measurements of eye movements; microCT; micro MRI; and finite element analysis. Our research subjects include computer models, circuits, animals and humans. For more information about VNEL, click here.
    VNEL is currently recruiting subjects for two first-in-human clinical trials:
    1) The MVI Multichannel Vestibular Implant Trial involves implantation of a “bionic” inner ear stimulator intended to partially restore sensation of head movement. Without that sensation, the brain’s image- and posture-stabilizing reflexes fail, so affected individuals suffer difficulty with blurry vision, unsteady walking, chronic dizziness, mental fogginess and a high risk of falling. Based on designs developed and tested successfully in animals over the past the past 15 years at VNEL, the system used in this trial is very similar to a cochlear implant (in fact, future versions could include cochlear electrodes for use in patients who also have hearing loss). Instead of a microphone and cochlear electrodes, it uses gyroscopes to sense head movement, and its electrodes are implanted in the vestibular labyrinth. For more information on the MVI trial, click here.
    2) The CGF166 Inner Ear Gene Therapy Trial involves inner ear injection of a genetically engineered DNA sequence intended to restore hearing and balance sensation by creating new sensory cells (called “hair cells”). Performed at VNEL with the support of Novartis and through a collaboration with the University of Kansas and Columbia University, this is the world’s first trial of inner ear gene therapy in human subjects. Individuals with severe or profound hearing loss in both ears are invited to participate. For more information on the CGF166 trial, click here.
    view more

    Research Areas: neuroengineering, audiology, multichannel vestibular prosthesis, balance disorders, balance, vestibular, prosthetics, cochlea, vestibular implant
  1. 1
  2. 2
Create lab profile
Edit lab profile
back to top button