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Research Lab Results for clinical trials

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  • Maureen Horton Lab

    Principal Investigator:
    Maureen Horton, M.D.
    Medicine

    The Maureen Horton Lab conducts research on pulmonary fibrosis through the use of both preclini...cal models and human trials. Our studies have helped to develop novel, genetic, tissue-specific models of immune dysfunction, which have aided in defining the immune regulation of fibrosis and in the development of treatment strategies. We have used T-cell skewing immunotherapy to prevent and reverse chemical-induced lung fibrosis and have conducted clinical trials for idiopathic pulmonary fibrosis (IPF), which led to one of the first treatments that helped to improve quality of life in IPF patients. view more

    Research Areas: interstitial lung diseases, idiopathic pulmonary fibrosis, pulmonary fibrosis, autoimmune diseases, occupational lung diseases, T cells
  • Molecular Oncology Laboratory

    Principal Investigator:
    Valsamo Anagnostou, M.D., Ph.D.
    Oncology

    Our Molecular Oncology lab seeks to understand the genomic wiring of response and resistance to... immunotherapy through integrative genomic, transcriptomic, single-cell and liquid biopsy analyses of tumor and immune evolution. Through comprehensive exome-wide sequence and genome-wide structural genomic analyses we have discovered that tumor cells evade immune surveillance by elimination of immunogenic mutations and associated neoantigens through chromosomal deletions. Additionally, we have developed non-invasive molecular platforms that incorporate ultra-sensitive measurements of circulating cell-free tumor DNA (ctDNA) to assess clonal dynamics during immunotherapy. These approaches have revealed distinct dynamic ctDNA and T cell repertoire patterns of clinical response and resistance that are superior to radiographic response assessments. Our work has provided the foundation for a molecular response-adaptive clinical trial, where therapeutic decisions are made not based on imaging but based on molecular responses derived from liquid biopsies. Overall, our group focuses on studying the temporal and spatial order of the metastatic and immune cascade under the selective pressure of immune checkpoint blockade with the ultimate goal to translate this knowledge into “next-generation” clinical trials and change the way oncologists select patients for immunotherapy. view more

    Research Areas: integrative mutli-omic analyses, Cancer genomics, liquid biopsies, tumor evolution, lung cancer, immunogenomic biomarkers
  • Nicholas Rowan Lab

    Dr. Rowan is actively involved in both outcomes and translational research relating to chronic ...rhinosinusitis and endoscopic skull base surgery. He has a keen interest patient-reported quality of life outcomes as well as those that pertain to smell and taste. Dr. Rowan is also involved in sinus-related clinical trials, pursuing new medical therapies and technological advancements for the treatment of patients with chronic rhinosinusitis. view more

    Research Areas: clinical trials, smell and taste outcomes, Quality of life outcomes
  • Richard Chaisson Lab

    Principal Investigator:
    Richard Chaisson, M.D.
    Medicine

    Research in the Richard Chaisson Lab primarily examines tuberculosis and HIV infection, with sp...ecific focus on global epidemiology, clinical trials, diagnostics and public health interventions. Our recent research has involved evaluating a molecular diagnostic test for tuberculosis in HIV patients; observing TB responses during treatment of pulmonary tuberculosis; and examining antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. view more

    Research Areas: global health, epidemiology, infectious disease, AIDS, HIV, tuberculosis
  • Robert Wise Lab

    Principal Investigator:
    Robert Wise, M.D.
    Medicine

    The Robert Wise Lab conducts clinical trials to study chronic obstructive lung diseases (COPD).... We investigate inhaled corticosteroids in patients with mild to moderate COPD and the effectiveness of anti-inflammatories in allowing lung growth in mild to moderate asthmatic children. Our research includes exploring the efficacy of various treatments for asthmatic women who are pregnant and of lung-volume reduction surgery for emphysema patients. We also conduct studies of the clinical epidemiology, pathobiology and treatment of interstitial lung disease in patients with scleroderma. view more

    Research Areas: critical care medicine, emphysema, scleroderma, pulmonary medicine, asthma, lung-volume reduction surgery, COPD
  • Roy Brower Lab

    Principal Investigator:
    Roy Brower, M.D.
    Medicine

    The Roy Brower Lab conducts clinical trials related to the management of acute respiratory dist...ress syndrome (ARDS). Our research also involves oxygen toxicity, a potentially fatal condition caused by too much supplemental oxygen. view more

    Research Areas: acute respiratory distress syndrome, oxygen toxicity, acute lung injury
  • Saleh Alqahtani Lab

    Principal Investigator:
    Saleh Alqahtani, M.B.Ch.B., M.S.
    Medicine

    The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver diseas...e and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients. view more

    Research Areas: fatty liver disease, Hepatitis, liver transplants, cirrhosis, liver diseases, liver cancer
  • Sherita Golden Lab

    Principal Investigator:
    Sherita Golden, M.D., M.H.S.
    Medicine

    Research in the Sherita Golden Lab focuses on identifying endocrine risk factors associated wit...h the development of diabetes and cardiovascular disease. We conduct our research by incorporating measures of hormonal function into the design of clinical trials of cardiovascular risk modification, observational studies of incident cardiovascular disease and diabetes, and studies evaluating diabetic complications. view more

    Research Areas: epidemiology, stress, hormones, diabetes, cardiovascular diseases, endocrinology
  • Spinal Column Surgical Outcomes Lab

    Lab Website
    Principal Investigator:
    Ali Bydon, M.D.
    Neurosurgery

    The Spinal Column Surgical Outcomes Laboratory aims to improve the neurological outcomes and fu...nctional capacity of patients undergoing spinal surgery. We collect large-scale retrospective patient databases and prospective patient registries to report high-quality data relating to the outcomes of neurosurgical operations. The laboratory participates in the National neurosurgical Quality and Outcomes Database (N2QOD). This multi-institutional collaboration has set forth a 3-year prospective study to benchmark quality and surgical outcome measures across several academic institutions. The Spinal Column Surgical Outcomes Laboratory specializes in biostatistical analysis of large-scale clinical databases, studying the outcomes of traditional and novel spinal procedures, quality control and cost-effectiveness research and clinical trials relating to spinal surgery outcomes. view more

    Research Areas: spine
  • Steven Levin Lab

    Lab Website

    Research in the Steven Levin Lab focuses on chemical neurolysis, epiduroscopy (and training for... physicians), opioid administration, and the use of alternative therapies for pain management. In collaboration with the American Society of Law, Medicine and Ethics and with funding from a Donahue Foundation Grant, we study social and ethical considerations in pain management. We have also been involved in clinical trials of novel analgesics. view more

    Research Areas: opioids, pain management, chemical neurolysis, epiduroscopy
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