At the brain tumor laboratory, Henry Brem, M.D. and Betty Tyler, along with more than 350 train...ees, have conducted scientific research, contributed to scientific literature, amended clinical practice, and illuminated new pathways for improving clinical outcomes.



The laboratory has advanced the understanding of gene therapy, angiogenesis, intracranial implantation of biodegradable polymers to treat malignant glioma, tumor genetics and proteomics, microchip drug delivery and drug resistance studies. Dr. Brem and his colleagues have designed and led many multi-institutional clinical trials to improve and expand the range of therapeutic options for patients with brain tumors. view more

The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection contro...l and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence. view more

Researchers in the Elizabeth Hunt Lab study innovative ways to improve the care quality and cli...nical outcomes of children who suffer cardiopulmonary arrest. Our work includes implementing rapid-response systems, capturing and analyzing cardiac-arrest data, and redesigning medical devices and simulators. We've introduced novel simulation approaches to education, including data-driven debriefing and the Rapid Cycle Deliberate Practice approach. view more

Research in the Jonathan Orens Lab examines topics such as clinical outcomes of lung transplant...ation, chronic allograft rejection and ischemic reperfusion injury, also known as primary graft dysfunction. view more

Research in the Sanjay Desai Lab focuses primarily on clinical outcomes in survivors of critica...l illnesses, such as acute lung injury. We also investigate techniques to improve graduate medical education and are conducting a clinical trial on the comparative effectiveness of models that optimize patient safety and resident education. Our research examines factors such as residency work-hour reform, hand hygiene practices and the use of etiquette-based communication. view more