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Displaying 51 to 57 of 57 results for cardiovascular

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  • The Arking Lab

    The Arking Lab studies the genomics of complex human disease, with the primary goal of identifying and characterizing genetics variants that modify risk for human disease. The group has pioneered the use of genome-wide association studies (GWAS), which allow for an unbiased screen of virtually all common genetic variants in the genome. The lab is currently developing improved GWAS methodology, as well as exploring the integration of additional genome level data (RNA expression, DNA methylation, protein expression) to improve the power to identify specific genetic influences of disease.

    The Arking Lab is actively involved in researching:
    • autism, a childhood neuropsychiatric disorder
    cardiovascular genomics, with a focus on electrophysiology and sudden cardiac death (SCD)
    • electrophysiology is the study of the flow of ions in biological tissues

    Dan E. Arking, PhD, is an associate professor at the McKusick-Nathans Institute of Genetic Medicine and Department of Medicine, D...ivision of Cardiology, Johns Hopkins University. view more

    Research Areas: autism, genetics, aging, cardiovascular diseases, sudden cardiac death

    Principal Investigator

    Dan Arking, Ph.D.

    Department

    Medicine

  • The Atlantic Cardiovascular Patient Outcomes Research Team - Atlantic C-PORT

    Our research is centered on the safety, efficacy and outcomes of PCI performed at hospitals without on-site cardiac surgery.

    Active projects:

    C-PORT Randomized Studies and Registries; New Jersey Angioplasty Demonstration Project; InCar-decision support tools for performance of PCI at hospitals without on-site cardiac surgery.

    For more information please visit Cport.org.

    Research Areas: cardiac surgery, cardiology

    Principal Investigator

    Thomas Aversano, M.D.

    Department

    Medicine

  • The Barouch Lab

    The Barouch Lab is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function.

    The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

    Lili Barouch, MD,... is an associate professor of medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine. view more

    Research Areas: cardiac remodeling, cardiac hypertrophy, obesity, cognitive heart failure

    Principal Investigator

    Lili Barouch, M.D.

    Department

    Medicine

  • The Halushka Lab

    The Halushka laboratory is interested in the overarching question of expression localization in tissues. To address this, the laboratory has set out upon several avenues of discovery in the areas of microRNA expression, proteomics and tissue gene expression. Many of these queries relate to the cardiovascular field as Dr. Halushka is a cardiovascular pathologist. Come learn about the science being done in the laboratory.

    Research Areas: genomic sciences, cardiovascular, genomic technologies, cardiovascular diseases

    Lab Website

    Principal Investigator

    Marc Halushka, M.D., Ph.D.

    Department

    Pathology

  • Viachaslau Barodka Lab

    Work in the Viachaslau Barodka Lab focuses on key topics within the field of anesthesiology research, including vascular stiffness, blood transfusions and cardiovascular physiology. Our most recent studies have explored impaired red blood cell deformability following blood transfusions, the effects of erythrocyte storage duration on blood transfusions, perioperative use of angiotensin-converting enzyme inhibitors and the pathophysiology of vascular stiffness.

    Research Areas: blood transfusions, cardiovascular physiology, anesthesiology

  • Wei Dong Gao Lab

    Work in the Wei Dong Gao Lab primarily focuses on heart failure and defining molecular and cellular mechanisms of contractile dysfunction. We use molecular biology and proteomic techniques to investigate the changes that myofilament proteins undergo during heart failure and under drug therapy. We're working to determine the molecular nature of nitroxyl (HNO) modification of tropomyosin.

    Research Areas: heart disease, contractile dysfunction, heart failure, cardiovascular diseases, molecular biology

  • Zack Wang Lab

    The Wang lab focuses on the signals that direct the differentiation of pluripotent stem cells, such as induced-pluripotent stem (iPS) cells, into hematopoietic and cardiovascular cells. Pluripotent stem cells hold great potential for regenerative medicine. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation.

    Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy

    Principal Investigator

    Zack Wang, Ph.D.

    Department

    Medicine

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