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Research Lab Results for cardiovascular

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  • Shelby Kutty Laboratory

    Shelby Kutty, M.D., Ph.D., is an authority on cardiovascular imaging, including echocardiograph...y, magnetic resonance imaging and computed tomography of congenital heart disease. His areas of academic interest have focused on myocardial function assessment, therapeutic ultrasound and cardiovascular outcomes. Kutty’s research includes developing new imaging technology applications such as a smartphone application that uses patients’ echocardiographic images to track their progress. His work gives pediatric cardiologists better ways to predict outcomes in their patients and provide the most effective and appropriate treatments. view more

    Research Areas: pediatric cardiology
  • Sherita Golden Lab

    Principal Investigator:
    Sherita Golden, M.D., M.H.S.
    Medicine

    Research in the Sherita Golden Lab focuses on identifying endocrine risk factors associated wit...h the development of diabetes and cardiovascular disease. We conduct our research by incorporating measures of hormonal function into the design of clinical trials of cardiovascular risk modification, observational studies of incident cardiovascular disease and diabetes, and studies evaluating diabetic complications. view more

    Research Areas: epidemiology, stress, hormones, diabetes, cardiovascular diseases, endocrinology
  • Sleep Apnea Pathogenesis

    Lab Website
    Principal Investigator:
    Vsevolod Polotsky, M.D., Ph.D.
    Medicine

    Our research laboratory is staffed by a dedicated and experienced team of sleep scientists, fel...lows, technicians, engineers, and students. Currently, we are focused on the following areas:

    -Novel treatments for sleep apnea using electrical and nerve stimulation and chemogenetic techniques

    -Cardiovascular and metabolic effects of sleep apnea and hypoxia

    -Leptin and its impact on breathing and cardiovascular physiology

    -Sleep disordered breathing at high altitude

    -Dietary impacts on asthma
    view more

    Research Areas: hypoxia, sleep apnea
  • Stephen Sozio Lab

    Principal Investigator:
    Stephen Sozio, M.D.
    Medicine

    Dr. Sozio’s research focuses on 1) Clinical research related to chronic kidney disease and end ...stage renal disease, and 2) Educational research in undergraduate and graduate medical education.



    The Sozio lab pursues work related to stroke, cognitive impairment, manifestations of kidney disease, and systematic reviews on clinical topics, and collaborates on multiple projects with other key investigators. In particular, Dr. Sozio has been an active investigator in the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study, Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) Study, Chronic Renal Insufficiency Cohort (CRIC) Study, and work funded through the Agency for Healthcare Research and Quality (AHRQ) and Johns Hopkins Evidence-Based Practice Center. In addition, the Sozio lab performs studies at the UME and GME levels, investing in understanding learners’ mentorship, research, and transitional experiences.
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    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke
  • Systems Biology Laboratory

    The Systems Biology Lab applies methods of multiscale modeling to problems of cancer and cardio...vascular disease, and examines the systems biology of angiogenesis, breast cancer and peripheral artery disease (PAD).

    Using coordinated computational and experimental approaches, the lab studies the mechanisms of breast cancer tumor growth and metastasis to find ways to inhibit those processes.

    We use bioinformatics to discover novel agents that affect angiogenesis and perform in vitro and in vivo experiments to test these predictions. In addition we study protein networks that determine processes of angiogenesis, arteriogenesis and inflammation in PAD. The lab also investigates drug repurposing for potential applications as stimulators of therapeutic angiogenesis, examines signal transduction pathways and builds 3D models of angiogenesis.

    The lab has discovered over a hundred novel anti-angiogenic peptides, and has undertaken in vitro and in vivo studies testing their activity under different conditions. We have investigated structure-activity relationship (SAR) doing point mutations and amino acid substitutions and constructed biomimetic peptides derived from their endogenous progenitors. They have demonstrated the efficacy of selected peptides in mouse models of breast, lung and brain cancers, and in age-related macular degeneration.

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    Research Areas: peripheral artery disease, breast cancer, systems biology, computational biology, cancer, cardiovascular, age-related macular degeneration, bioinformatics, angiogenesis, microcirculation
  • The Arking Lab

    Principal Investigator:
    Dan Arking, Ph.D.
    Medicine

    The Arking Lab studies the genomics of complex human disease, with the primary goal of identify...ing and characterizing genetics variants that modify risk for human disease. The group has pioneered the use of genome-wide association studies (GWAS), which allow for an unbiased screen of virtually all common genetic variants in the genome. The lab is currently developing improved GWAS methodology, as well as exploring the integration of additional genome level data (RNA expression, DNA methylation, protein expression) to improve the power to identify specific genetic influences of disease.

    The Arking Lab is actively involved in researching:
    • autism, a childhood neuropsychiatric disorder
    cardiovascular genomics, with a focus on electrophysiology and sudden cardiac death (SCD)
    • electrophysiology is the study of the flow of ions in biological tissues

    Dan E. Arking, PhD, is an associate professor at the McKusick-Nathans Institute of Genetic Medicine and Department of Medicine, Division of Cardiology, Johns Hopkins University.
    view more

    Research Areas: autism, genetics, aging, cardiovascular diseases, sudden cardiac death
  • The Atlantic Cardiovascular Patient Outcomes Research Team - Atlantic C-PORT

    Principal Investigator:
    Thomas Aversano, M.D.
    Medicine

    Our research is centered on the safety, efficacy and outcomes of PCI performed at hospitals wit...hout on-site cardiac surgery.

    Active projects:

    C-PORT Randomized Studies and Registries; New Jersey Angioplasty Demonstration Project; InCar-decision support tools for performance of PCI at hospitals without on-site cardiac surgery.

    For more information please visit Cport.org.
    view more

    Research Areas: cardiac surgery, cardiology
  • The Barouch Lab

    Principal Investigator:
    Lili Barouch, M.D.
    Medicine

    The Barouch Lab is focused on defining the peripheral cardiovascular effects of the adipocytoki...ne leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function.

    The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

    Lili Barouch, MD, is an associate professor of medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine.
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    Research Areas: cardiac remodeling, cardiac hypertrophy, obesity, cognitive heart failure
  • The Halushka Lab

    Lab Website
    Principal Investigator:
    Marc Halushka, M.D., Ph.D.
    Pathology

    The Halushka laboratory is interested in the overarching question of expression localization in... tissues. To address this, the laboratory has set out upon several avenues of discovery in the areas of microRNA expression, proteomics and tissue gene expression. Many of these queries relate to the cardiovascular field as Dr. Halushka is a cardiovascular pathologist. Come learn about the science being done in the laboratory.
    view more

    Research Areas: genomic sciences, cardiovascular, genomic technologies, cardiovascular diseases
  • Zack Wang Lab

    Principal Investigator:
    Zack Wang, Ph.D.
    Medicine

    The Wang lab focuses on the signals that direct the differentiation of pluripotent stem cells, ...such as induced-pluripotent stem (iPS) cells, into hematopoietic and cardiovascular cells. Pluripotent stem cells hold great potential for regenerative medicine. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation. view more

    Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy
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