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Research Lab Results for cardiovascular

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  • Josef Coresh Lab

    Principal Investigator:
    Josef Coresh, M.D., Ph.D.
    Medicine

    Research in the Josef Coresh Lab focuses on cardiovascular epidemiology, kidney disease and gen...etic epidemiology. Our team uses innovative methods to quantify disease burden and consequences in the population; studies the causes and consequences of vascular disease in the heart, kidneys and brain; and works to develop a strong scientific basis for quantifying the burden, causes and consequences of kidney disease. Working in collaboration with leading laboratories and specialists, we also aim to quantify the interplay of genes and environment in health and disease. view more

    Research Areas: epidemiology, genetics, kidney diseases, cardiovascular, vascular diseases
  • Kathleen Gabrielson Laboratory

    Principal Investigator:
    Kathleen Gabrielson, D.V.M., Ph.D.
    Molecular and Comparative Pathobiology

    Research in the Kathleen Gabrielson Laboratory focuses on the signal transduction of cardiovasc...ular toxicities in vitro, in cardiomyocyte culture and in vivo using rodent models. Specifically, the research focuses on understanding the mechanisms of various cancer therapies that induce cardiac toxicities.

    Currently, we are testing prevention strategies for these toxicities by studying the cardiac effects of the anthracycline doxorubicin (adriamycin) and the immunotherapeutic agent, Herceptin, anti-erbB2. We are focusing on the signal transduction pathways in the heart that are modulated by anti-erbB2 treatment, which in turn, worsens doxorubicin toxicity. Thus, understanding the mechanisms behind the combined toxicity of doxorubicin and anti-erbB2 will pave the way for the design of strategies to reduce toxicity, identify patients at risk and potentially allow higher levels of this effective combination therapy to be used with an improved long-term survival in patients.
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    Research Areas: cardiovascular toxicity, cancer, pathology, signal transduction
  • Komatsu Lab

    Malfunction and malformation of blood vessels are associated with a broad range of medical cond...itions, including cancer, cardiovascular diseases, and neurological disorders. The ultimate goal of the Komatsu lab is to find a way to reverse the process of abnormal vessel formation and restore normal function to these vessels. In cancer, normalization of tumor blood vessels facilitates lymphocyte infiltration, potentiating anti-tumor immunity, and enhances the efficacy of immunotherapies as well as conventional cancer treatments. Normalization of regenerating blood vessels is also necessary for reestablishing blood flow to ischemic hearts and limbs, and preventing blindness caused by diabetic retinopathy or macular degeneration. Komatsu lab’s research is uncovering key molecular pathways important for the normalization of pathological vasculature. view more

    Research Areas: Tertiary lymphoid structure (TLS) in cancer, Drug targeting, High endothelial venules and their role in lymphocyte recruitment, Vascular normalization
  • Lakshmi Santhanam Lab

    Investigators in the Lakshmi Santhanam Lab examine the fundamental mechanisms behind cardiovasc...ular disease. They are particularly interested in better understanding how nitric oxide-mediated S-nitrosylation (a post-translational protein modification) impacts protein function and trafficking in the vasculature as well as how this relationship influences matrix remodeling and vascular stiffening. view more

    Research Areas: vasculature trafficking, protein trafficking, S-nitrosation, protein function, nitric oxide, matrix remodeling, vascular stiffness, cardiovascular diseases
  • Lima Lab

    Lab Website
    Principal Investigator:
    Joao Lima, M.D., M.B.A.
    Medicine

    The Lima Lab’s research is concentrated on the development and application of imaging and techn...ology to address scientific and clinical problems involving the heart and vascular system.

    Specifically, our research is focused on developing magnetic resonance imaging (MRI) contrast techniques to investigate microvascular function in patients and experimental animals with myocardial infarction; functional reserve secondary to dobutamine stimulation and myocardial viability assessed by sodium imaging; and cardiac MRI and computed tomography (CT) program development of techniques to characterize atherosclerosis in humans with cardiovascular or cerebrovascular disease.

    Current projects include:
    • The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    • The MESA (Multi-Ethnic Study of Atherosclerosis) Study
    • The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) Study

    Joao Lima, MD, is a professor of medicine, radiology and epidemiology at the Johns Hopkins School of Medicine.
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    Research Areas: magnetic resonance, cerebrovascular, imaging, cardiovascular, cardiology, atherosclerosis, computed tomography, vascular, myocardial infarction
  • Lisa Cooper Lab

    Lab Website
    Principal Investigator:
    Lisa Cooper, M.D., M.P.H.
    Medicine

    The Lisa Cooper Lab is dedicated to researching patient-centered interventions for improving he...alth outcomes and overcoming racial and ethnic disparities in health care. Our primary focus is on the factors of physician communication skills and cultural competence training, patient shared decision-making and self-management skills training. Recently, we have explored patient-centered depression care for African Americans, tactics for improving patient-physician communication about management of hypertension, and reducing ethnic and social disparities in health. In addition, we are currently researching racial disparities in cardiovascular health outcomes for patients living in Baltimore. view more

    Research Areas: epidemiology, patient-centered health care, patient-provider relationships, hypertension, race, health services research, cultural competence, health disparities
  • Lisa Yanek Lab

    Principal Investigator:
    Lisa Yanek, M.P.H.
    Medicine

    Research in the Lisa Yanek Lab focuses on cardiovascular disease in families and risk factor mo...dification. Recently, we conducted a study to determine the association of lean versus fat mass with fitness in healthy, overweight and obese African Americans from families with early-onset coronary disease. view more

    Research Areas: African Americans, cardiovascular diseases, risk factor modification
  • Maryam Jahromi Lab

    The Maryam Jahromi Lab researches infectious diseases such as influenza, tuberculosis, endocard...itis, viral hemorrhagic fevers, brucellosis, Clostridium difficile and Crimean-Congo hemorrhagic fever. We are particularly interested in the impact of the influenza vaccine on systemic inflammation. Recent areas of focus include the relationship between influenza vaccination and cardiovascular outcomes, the emergence of Crimean-Congo hemorrhagic fever in Iran, and prospects for vaccines and therapies for Crimean-Congo hemorrhagic fever. view more

    Research Areas: vaccines, infectious disease, patient outcomes, inflammation, cardiovascular diseases, flu, Crimean-Congo hemorrhagic fever
  • Nauder Faraday Lab

    Lab Website

    The Nauder Faraday Lab investigates topics within perioperative genetic and molecular medicine.... We explore thrombotic, bleeding and infectious surgical complications. Our goal is to uncover the molecular determinants of outcome in surgical patients, which will enable surgeons to better personalize a patient’s care in the perioperative period. Our team is funded by the National Institutes of Health to research platelet phenotypes, the pharmacogenomics of antiplatelet agents for preventing cardiovascular disease, and the genotypic determinants of aspirin response in high-risk families. view more

    Research Areas: cardiac surgery, molecular medicine, post-surgical outcomes, genomics, cardiovascular diseases, post-surgery complications
  • Nicholas Flavahan Lab

    Lab Website

    The Nicholas Flavahan Lab primarily researches the cellular interactions and subcellular signal...ing pathways that control normal vascular function and regulate the initiation of vascular disease. We use biochemical and molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells, while also conducting physiological assessments and fluorescent microscopic imaging of signaling systems in isolated blood vessels. A major component of our research involves aterioles, tiny blood vessles that are responsible for controlling the peripheral resistance of the cardiovascular system, which help determine organ blood flow. view more

    Research Areas: biochemistry, Raynaud's phenomenon, vascular biology, vasospasms
  • Nicola Heller Lab

    Lab Website

    Research in the Nicola Heller Lab focuses on the immunobiology of macrophages. Our team explore...s how these cells impact diseases with an inflammatory element, such as cancer, cardiovascular disease and obesity. Using a variety of techniques, including molecular and cellular biology, biochemistry, mouse models and more, we study the role of IL-4/IL-13 signaling in asthma and allergic disease, as well as the role of alternatively activated macrophages (AAM) in the pathogenesis of allergic inflammation. Currently, we are researching the links between asthma and obesity, with a focus on the roles of gender and race. view more

    Research Areas: asthma, allergies, immunobiology, inflammation, macrophages
  • Obesity Hypertension Clinic: Reversing the Negative Cardiovascular Effects of Weight (ReNEW)

    Lab Website
    Principal Investigator:
    Tammy Brady, M.D., Ph.D.
    Medicine
    Pediatrics

    Hypertension in children is a major cause of disease, including early onset heart disease. Up t...o 25% of children who are overweight or obese have hypertension (high blood pressure), and children with obesity are at greater risk for having other cardiovascular disease risk factors such as high cholesterol and diabetes. The ReNEW Clinic at The Johns Hopkins University provides an innovative multidisciplinary approach to the evaluation and treatment of obesity-related hypertension to help prevent and treat cardiovascular disease. This clinic is designed for children with elevated blood pressure (prehypertension and hypertension) and a BMI at or above the 85th percentile. Many children in this clinic are enrolled in a longitudinal registry to help researchers learn how to better care for children with multiple risk factors for heart disease.

    Read more about the ReNEW clinic: Childhood Obesity: A Focus on Hypertension

    view more

    Research Areas: obesity, hypertension, pediatric cardiology
  • Paul Ladenson Lab

    Principal Investigator:
    Paul Ladenson, M.D.
    Medicine

    The Paul Ladenson Lab studies the application of thyroid hormone analogues for treating cardiov...ascular disease; novel approaches to thyroid cancer diagnosis and management; and the health economic analyses related to thyroid patient care. view more

    Research Areas: thyroid cancer, cardiovascular diseases, endocrinology
  • Pediatric Cardiology Core Imaging Laboratory

    Principal Investigator:
    Shelby Kutty, M.D., Ph.D., M.S.
    Medicine

    The lab’s assets include three MRI systems available for pediatric studies, cardiac imaging pro...cessing, cardiovascular imaging and therapeutic ultrasound. A robust echocardiogram program conducts 10,000 transthoracic echocardiograms and 1,300 fetal echocardiograms per year, and maintains a database with 10 years of data. view more

    Research Areas: cardiac imaging, pediatric cardiology
  • Platelet Physiology Research Lab

    Principal Investigator:
    Marlene Williams, M.D.
    Medicine

    Dr. Williams' research focuses on platelet physiology particularly as it relates to acute coron...ary syndromes and depression. Her laboratory specifically examines platelet aggregation, flow cytometric analysis to measure platelet activation, platelet luminescence as a measure of the platelet release reaction, many Elisa preparations in order to measure platelet function, platelet genotyping to determine the presence of certain platelet polymorphisms, and various other assays to distinguish mechanisms of platelet dysfunction. The goal for her cardiovascular platelet laboratory is to identify the etiology of platelet dysfunction in many disease states and apply methods that may improve this dysfunction that can eventually be translated to therapies for patients with cardiovascular disease. Scientific techniques performed in the lab include: flow cytometric analysis, platelet microparticle identification, and protein immunoprecipitation among other techniques. view more

    Research Areas: platelets, Platelet drug response, Platelet Flow cytometric analysis, Platelet Aggregation
  • Pluznick Lab

    Lab Website
    Principal Investigator:
    Jennifer Pluznick, Ph.D.
    Physiology

    The Pluznick Lab is interested in the role that chemosensation plays in regulating physiologica...l processes, particularly in the kidney and the cardiovascular system. We have found that sensory receptors (olfactory receptors, taste receptors, and other G-protein coupled receptors) are expressed in the kidney and in blood vessels, and that individual receptors play functional roles in whole-animal physiology. We are currently working to identify the full complement of sensory receptors found in the kidney, and are working to understand the role that each receptor plays in whole-animal physiology by using a variety of in vitro (receptor localization, ligand screening) and in vivo (whole-animal physiology) techniques. view more

    Research Areas: sensory receptors, cardiovascular, physiology, chemosensation, renal
  • Post Lab

    Lab Website
    Principal Investigator:
    Wendy Post, M.D., M.S.
    Medicine

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative s...tudy of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
    view more

    Research Areas: coronary artery disease, cardiovascular, ethnicity, pathogenesis, atherosclerosis, sudden cardiac death
  • Ratchford Lab

    Principal Investigator:
    Elizabeth Ratchford, M.D.
    Medicine

    Prospective registry looking at cardiovascular risk assessment and risk reduction among firefig...hters. view more

    Research Areas: Cardiovascular Disease Prevention
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