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Displaying 21 to 30 of 54 results for cardiovascular

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  • Jochen Steppan Lab

    Research in the Jochen Steppan Lab primarily focused on vascular stiffness related to aging. We are currently researching LOXL2 (lysine-oxidase-like-2), which might be intimately involved in the development or progression of vascular stiffness. We aim to better understand LOXL2's role in the vasculature and hope that this work leads to the characterization of a novel therapeutic target. This is important in the treatment of cardiovascular diseases in the aging population.

    Research Areas: aging, vascular stiffness, cardiovascular diseases

  • Josef Coresh Lab

    Research in the Josef Coresh Lab focuses on cardiovascular epidemiology, kidney disease and genetic epidemiology. Our team uses innovative methods to quantify disease burden and consequences in the population; studies the causes and consequences of vascular disease in the heart, kidneys and brain; and works to develop a strong scientific basis for quantifying the burden, causes and consequences of kidney disease. Working in collaboration with leading laboratories and specialists, we also aim to quantify the interplay of genes and environment in health and disease.

    Research Areas: epidemiology, genetics, kidney diseases, cardiovascular, vascular diseases

    Principal Investigator

    Josef Coresh, M.D., Ph.D.

    Department

    Medicine

  • Kathleen Gabrielson Laboratory

    Research in the Kathleen Gabrielson Laboratory focuses on the signal transduction of cardiovascular toxicities in vitro, in cardiomyocyte culture and in vivo using rodent models. Specifically, the research focuses on understanding the mechanisms of various cancer therapies that induce cardiac toxicities.

    Currently, we are testing prevention strategies for these toxicities by studying the cardiac effects of the anthracycline doxorubicin (adriamycin) and the immunotherapeutic agent, Herceptin, anti-erbB2. We are focusing on the signal transduction pathways in the heart that are modulated by anti-erbB2 treatment, which in turn, worsens doxorubicin toxicity. Thus, understanding the mechanisms behind the combined toxicity of doxorubicin and anti-erbB2 will pave the way for the design of strategies to reduce toxicity, identify patients at risk and potentially allow higher levels of this effective combination therapy to be used with an improved long-term survival in patients.

    Research Areas: cardiovascular toxicity, cancer, pathology, signal transduction

    Principal Investigator

    Kathleen Gabrielson, D.V.M., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Lakshmi Santhanam Lab

    Investigators in the Lakshmi Santhanam Lab examine the fundamental mechanisms behind cardiovascular disease. They are particularly interested in better understanding how nitric oxide-mediated S-nitrosylation (a post-translational protein modification) impacts protein function and trafficking in the vasculature as well as how this relationship influences matrix remodeling and vascular stiffening.

    Research Areas: vasculature trafficking, protein trafficking, S-nitrosation, protein function, nitric oxide, matrix remodeling, vascular stiffness, cardiovascular diseases

  • Lee Bone Lab

    Research in the Lee Bone Lab uses community-based participatory approaches to promote health in underserved urban African-American populations. We conduct randomized clinical trials on cardiovascular disease, diabetes and cancer detection and control in order to test the success of community interventions. We focus in particular on making interventions sustainable and on implementing electronic education to improve communication.

    Research Areas: African Americans, cancer, diabetes, community outreach, cardiovascular diseases, community health education

    Principal Investigator

    Lee Bone, M.P.H.

    Department

    Medicine

  • Lewis Romer Lab

    Work in the Lewis Romer Lab focuses on the responses of vascular systems to disease and injury. Using cultured human endothelial cells and fibroblasts from mice that lack expression of the FAK- or Src-family kinases, we’re exploring several topics. These include the effect of inflammatory cytokine on cell adhesion to the extracellular matrix; the role of FAK signaling in inhibiting apoptosis; and the function of FAK- and Src-family kinases in cell-matrix interactions during adhesion and motility.

    Research Areas: microscopy, cellular biology, vascular biology, cardiovascular diseases

  • Lima Lab

    The Lima Lab’s research is concentrated on the development and application of imaging and technology to address scientific and clinical problems involving the heart and vascular system.

    Specifically, our research is focused on developing magnetic resonance imaging (MRI) contrast techniques to investigate microvascular function in patients and experimental animals with myocardial infarction; functional reserve secondary to dobutamine stimulation and myocardial viability assessed by sodium imaging; and cardiac MRI and computed tomography (CT) program development of techniques to characterize atherosclerosis in humans with cardiovascular or cerebrovascular disease.

    Current projects include:
    • The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    • The MESA (Multi-Ethnic Study of Atherosclerosis) Study
    • The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) Study

    Joao Lima, MD, is a professor of medicine, radiology and... epidemiology at the Johns Hopkins School of Medicine. view more

    Research Areas: magnetic resonance, cerebrovascular, imaging, cardiovascular, cardiology, atherosclerosis, computed tomography, vascular, myocardial infarction

    Lab Website

    Principal Investigator

    Joao Lima, M.B.A., M.D.

    Department

    Medicine

  • Lisa Cooper Lab

    The Lisa Cooper Lab is dedicated to researching patient-centered interventions for improving health outcomes and overcoming racial and ethnic disparities in health care. Our primary focus is on the factors of physician communication skills and cultural competence training, patient shared decision-making and self-management skills training. Recently, we have explored patient-centered depression care for African Americans, tactics for improving patient-physician communication about management of hypertension, and reducing ethnic and social disparities in health. In addition, we are currently researching racial disparities in cardiovascular health outcomes for patients living in Baltimore.

    Research Areas: epidemiology, patient-centered health care, patient-provider relationships, hypertension, race, health services research, cultural competence, health disparities

    Lab Website

    Principal Investigator

    Lisa Cooper, M.D., M.P.H.

    Department

    Medicine

  • Lisa Yanek Lab

    Research in the Lisa Yanek Lab focuses on cardiovascular disease in families and risk factor modification. Recently, we conducted a study to determine the association of lean versus fat mass with fitness in healthy, overweight and obese African Americans from families with early-onset coronary disease.

    Research Areas: African Americans, cardiovascular diseases, risk factor modification

    Principal Investigator

    Lisa Yanek, M.P.H.

    Department

    Medicine

  • Maryam Jahromi Lab

    The Maryam Jahromi Lab researches infectious diseases such as influenza, tuberculosis, endocarditis, viral hemorrhagic fevers, brucellosis, Clostridium difficile and Crimean-Congo hemorrhagic fever. We are particularly interested in the impact of the influenza vaccine on systemic inflammation. Recent areas of focus include the relationship between influenza vaccination and cardiovascular outcomes, the emergence of Crimean-Congo hemorrhagic fever in Iran, and prospects for vaccines and therapies for Crimean-Congo hemorrhagic fever.

    Research Areas: vaccines, infectious disease, patient outcomes, inflammation, cardiovascular diseases, flu, Crimean-Congo hemorrhagic fever

    Principal Investigator

    Maryam Keshtkar Jahromi, M.D., M.P.H.

    Department

    Medicine

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