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Research Lab Results for cardiovascular

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  • Adrian Dobs Lab

    Researchers in the Adrian Dobs Lab study topics that include gonadal dysfunction, hyperlipidemi...a, diabetes mellitus, and the relationship between sex hormones and heart disease. We currently are investigating male gonadal function—with particular interest in new forms of male hormone replacement therapy—and hormonal changes related to aging. view more

    Research Areas: diabetes mellitus, hormones, hyperlipidemia, male gonadal function, cardiovascular diseases, endocrinology
  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our... recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders. view more

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis
  • Ami Shah Lab

    Lab Website

    Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. We examine the rela...tionship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud’s phenomenon, and drugs that improve aspects of scleroderma. view more

    Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases
  • Anderson Lab

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    Research in the Anderson laboratory focuses on cellular signaling and ionic mechanisms that cau...se heart failure, arrhythmias and sudden cardiac death, major public health problems worldwide. Primary focus is on the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII). The laboratory identified CaMKII as an important pro-arrhythmic and pro-cardiomyopathic signal, and its studies have provided proof of concept evidence motivating active efforts in biotech and the pharmaceutical industry to develop therapeutic CaMKII inhibitory drugs to treat heart failure and arrhythmias.

    Under physiological conditions, CaMKII is important for excitation-contraction coupling and fight or flight increases in heart rate. However, myocardial CaMKII is excessively activated during disease conditions where it contributes to loss of intracellular Ca2+ homeostasis, membrane hyperexcitability, premature cell death, and hypertrophic and inflammatory transcription. These downstream targets appear to contribute coordinately and decisively to heart failure and arrhythmias. Recently, researchers developed evidence that CaMKII also participates in asthma.

    Efforts at the laboratory, funded by grants from the National Institutes of Health, are highly collaborative and involve undergraduate assistants, graduate students, postdoctoral fellows and faculty. Key areas of focus are:
    • Ion channel biology and arrhythmias
    • Cardiac pacemaker physiology and disease
    • Molecular physiology of CaMKII
    • Myocardial and mitochondrial metabolism
    • CaMKII and reactive oxygen species in asthma

    Mark Anderson, MD, is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital.
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    Research Areas: heart failure, arrhythmia, cardiovascular diseases, sudden cardiac death
  • Cardiovascular Analytical Intelligence Initiative (CV-Ai2)

    Lab Website

    Among the hundreds of predictive models developed for cardiovascular disease, less than one-ten...th of 1% actually end up routinely used in clinical practice. CV-Ai2 uses data from clinical practice and analytic intelligence to solve clinical problems and create solutions that can be applied in real-world patient care. view more

    Research Areas: cardiovascular diseases
  • Cardiovascular Stem Cell Program

    Lab Website

    The research program aims to advance cardiovascular biology and medicine by focusing on pluripo...tent stem cell-based modeling and therapy and by nurturing future leaders in regenerative medicine. view more

    Research Areas: cardiac, stem cells, cardiology, regenerative medicine
  • Cheryl Dennison Himmelfarb Lab

    Lab Website
    Principal Investigator:
    Cheryl Dennison, Ph.D.
    Dermatology

    Research in the Cheryl Dennison Lab aims to improve cardiovascular care for high-risk groups th...rough multidisciplinary and health information technology-based methods. Our studies focus on reducing system and provider obstacles to implementing cardiovascular guidelines in various health care environments. Additional research interests include chronic illness management, quality of care, interdisciplinary teamwork and provider behavior. view more

    Research Areas: cardiovascular diseases, quality of care, information technology, health disparities
  • Chulan Kwon Laboratory

    Lab Website

    The C. Kwon Lab studies the cellular and molecular mechanisms governing heart generation and re...generation.

    The limited regenerative capacity of the heart is a major factor in morbidity and mortality rates: Heart malformation is the most frequent form of human birth defects, and cardiovascular disease is the leading cause of death worldwide. Cardiovascular progenitor cells hold tremendous therapeutic potential due to their unique ability to expand and differentiate into various heart cell types.

    Our laboratory seeks to understand the fundamental biology and regenerative potential of multi-potent cardiac progenitor cells – building blocks used to form the heart during fetal development — by deciphering the molecular and cellular mechanisms that control their induction, maintenance, and differentiation. We are also interested in elucidating the maturation event of heart muscle cells, an essential process to generate adult cardiomyocytes, which occurs after terminal differentiation of the progenitor cells. We believe this knowledge will contribute to our understanding of congenital and adult heart disease and be instrumental for stem cell-based heart regeneration.

    We have developed several novel approaches to deconstruct the mechanisms, including the use of animal models and pluripotent stem cell systems. We expect this knowledge will help us better understand heart disease and will be instrumental for stem-cell-based disease modeling and interventions for of heart repair.

    Dr. Chulan Kwon is an assistant professor of medicine at the Johns Hopkins University Heart and Vascular Institute.
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    Research Areas: stem cells, cell biology, heart regeneration, congenital heart disease, cardiovascular, molecular biology, cardiac cells
  • Daniel Nyhan Lab

    Lab Website

    The Daniel Nyhan Lab studies vascular changes that accompany aging to determine the underlying ...causes and find ways to reverse the process. One goal of our research is to identify the factors that cause vascular stiffness. Our hope is that our work in vascular biology will lead to new ways to improve vascular compliance and thereby improve cardiovascular function and perioperative risk. view more

    Research Areas: hypertension, cardiovascular, vascular biology, vascular diseases
  • Dara Kraitchman Laboratory

    Lab Website

    The Dara Kraitchman Laboratory focuses on non-invasive imaging and minimally invasive treatment... of cardiovascular disease. Our laboratory is actively involved in developing new methods to image myocardial function and perfusion using MRI. Current research interests are aimed at determining the optimal timing and method of the administration of mesenchymal stem cells to regenerate infarcted myocardium using non-invasive MR fluoroscopic delivery and imaging. MRI and radiolabeling techniques include novel MR and radiotracer stem cell labeling methods to determine the location, quantity and biodistribution of stem cells after delivery as well as to noninvasively determine the efficacy of these therapies in acute myocardial infarction and peripheral arterial disease.

    Our other research focuses on the development of new animal models of human disease for noninvasive imaging studies and the development of promising new therapies in clinical trials for companion animals.
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    Research Areas: imaging, cardioavascular, radiology, MRI, cardiomyopathy
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