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Research Lab Results for cardiomyopathy

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  • Anne Murphy Laboratory

    Principal Investigator:
    Anne Murphy, M.D.
    Medicine
    Pediatrics

    Anne Murphy’s laboratory studies cardiomyopathy and key proteins that are part of the contracti...le apparatus. The team is looking at how modifications to these proteins might affect various diseases and heart failure. She also investigates the role of genetics in pediatric heart failure associated with acute heart failure, which is sometimes attributed to myocarditis. Her laboratory has received grants from the American Heart Association, the National Institutes of Health and the Children’s Cardiomyopathy Foundation. Murphy received the Rowe Award for Cardiology Research from the Society for Pediatric Research and other awards. Her research on the molecular basis of myocardial stunning was named one of the top 10 research achievements for 1999 by the American Heart Association. view more

    Research Areas: pediatric cardiology, cardiomyopathy
  • Katherine Wilson Lab

    Principal Investigator:
    Katherine Wilson, Ph.D.
    Cell Biology

    Research in the Wilson Lab focuses on three components of nuclear lamina structure: lamins, LEM...-domain proteins (emerin), and BAF.

    These three proteins all bind each other directly, and are collectively required to organize and regulate chromatin, efficiently segregate chromosomes and rebuild nuclear structure after mitosis. Mutations in one or more of these proteins cause a variety of diseases including Emery-Dreifuss muscular dystrophy (EDMD), cardiomyopathy, lipodystrophy and diabetes, and accelerated aging.

    We are examining emerin's role in mechanotransduction, how emerin and lamin A are regulated, and whether misregulation contributes to disease.
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    Research Areas: cell biology, Emery-Dreifuss muscular dystrophy (EDMD), accelerated aging, chromatin, diabetes, genomics, emerin, nuclear lamina, lipodystrophy, cardiomyopathy
  • The Cihakova Lab

    Lab Website
    Principal Investigator:
    Daniela Cihakova, M.D., Ph.D.
    Pathology

    The Cihakova research laboratory is an immunology laboratory dedicated to the investigation of ...autoimmune diseases. Our most active research is focused on myocarditis and dilated cardiomyopathy. We expanded our interest in inflammatory heart diseases to include the study of immune mechanisms driving pericarditis and myocardial infarction. In addition, we are interested in the pathogenesis of a broad range of autoimmune diseases such as, Sjogren's syndrome, congenital complete heart block, and APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). Through several collaborative projects we also investigate rheumatoid arthritis and the immune components of schizophrenia. view more

    Research Areas: schizophrenia, autoimmune diseases, myocardial infarction, cardiomyopathy
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