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Displaying 101 to 126 of 126 results for cancer

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  • Saraswati Sukumar Lab

    Our lab is focused on using comprehensive gene expression, methylation and sequencing and metabolomics analysis to identify alterations in breast cancer, and exploiting these for early detection and therapy. Among deferentially expressed genes, our lab has focused on the HOX genes. HOX genes are intimately involved in the development of resistance to both chemotherapy and to agents targeting the estrogen receptor. Our work explores the alternate pathways that are activated by HOX proteins leading to this resistance and novel treatments to overcome resistance in both tissue culture and xenograft models. In addition, epigenetically silenced genes and a metabolic reprogramming in tumors also trigger novel early detection and therapeutic strategies. We are testing the utility of differentiation therapy through reactivating RAR-beta in breast cancer using histone deacetylase inhibitors with great success. Also, we are targeting enzymes involved in gluconeogenesis and glycolysis with small ...molecule FDA-approved antimetabolites to achieve antitumor effects. view more

    Research Areas: breast cancer, genetics

    Lab Website

    Principal Investigator

    Saraswati Sukumar, Ph.D.

    Department

    Oncology

  • Sean Taverna Laboratory

    The Taverna Laboratory studies histone marks, such as lysine methylation and acetylation, and how they contribute to an epigenetic/histone code that dictates chromatin-templated functions like transcriptional activation and gene silencing. Our lab uses biochemistry and cell biology in a variety of model organisms to explore connections between gene regulation and proteins that write and read histone marks, many of which have clear links to human diseases like leukemia and other cancers. We also investigate links between small RNAs and histone marks involved in gene silencing.

    Research Areas: biochemistry, histone marks, cell biology, leukemia, cancer, epigenetics, eukaryotic cells, gene silencing, RNA

  • Shawn Lupold Laboratory

    The Shawn Lupold Laboratory studies the biology of urologic malignancies, like prostate cancer, to create new experimental diagnostic, prognostic and therapeutic agents.

    Research Areas: prostate cancer, urologic cancers

    Lab Website

    Principal Investigator

    Shawn Lupold, Ph.D.

    Department

    Urology

  • Shyam Sundar Biswal Lab

    xResearch in the Shyam Biswal Lab focuses on therapeutic resistance of cancer due to a gain-of-function mutation in transcription factor Nrf2. Using patient-derived xenografts in humanized immunocompetent mice and GEM models, we aim to understand the mechanisms of oncogenic cooperation and metabolic adaptation in cancer cells. We’re also investigating the systemic and pulmonary effects of air pollution as well as the health effects of recent tobacco products, such as electronic cigarettes and water pipes.

    Research Areas: Nrf2, tobacco use, genetics, cancer, pulmonary medicine, environment, lung cancer

    Principal Investigator

    Shyam Biswal, Ph.D.

    Department

    Medicine

  • Solomon Snyder Laboratory

    Information processing in the brain reflects communication among neurons via neurotransmitters. The Solomon Snyder Laboratory studies diverse signaling systems including those of neurotransmitters and second messengers as well as the actions of drugs upon these processes. We are interested in atypical neurotransmitters such as nitric oxide (NO), carbon monoxide (CO), and the D-isomers of certain amino acids, specifically D-serine and D-aspartate. Our discoveries are leading to a better understanding of how certain drugs for Parkinson's disease and Hungtington's disease interact with cells and proteins. Understanding how other second messengers work is giving us insight into anti-cancer therapies.

    Research Areas: Huntington's disease, amino acids, neurotransmitters, brain, cancer, nitric oxide, drugs, carbon monoxide, Parkinson's disease, nervous system

  • Spyridon Marinopoulos Lab

    Research interests in the Spyridon Marinopoulos Lab include evidence-based medicine. Recently, we examined the impact of health information technology (IT) that supports patient-centered care (PCC) and found substantial evidence that health IT applications with PCC-related components have a positive effect on health care outcomes.

    Research Areas: breast cancer, patient-centered health care, health IT, diabetes, evidence-based medicine

    Principal Investigator

    Spyridon Marinopoulos, M.B.A., M.D.

    Department

    Medicine

  • Srinivasan Yegnasubramanian Lab

    Dr. Yegnasubramanian directs a Laboratory of Cancer Molecular Genetics and Epigenetics at the Sidney Kimmel Comprehensive Cancer Center (SKCCC), and is also the Director of the SKCCC Next Generation Sequencing Center.


    Our lab research is focused on understanding the complex interplay between genetic and epigenetic alterations in carcinogenesis and disease progression, and to exploit this understanding in developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention.

    Research Areas: cancer therapies, biomarkers, genetics, cancer, epigenetics

  • Stivers Lab

    The Stivers Lab is broadly interested in the biology of the RNA base uracil when it is present in DNA. Our work involves structural and biophysical studies of uracil recognition by DNA repair enzymes, the central role of uracil in adapative and innate immunity, and the function of uracil in antifolate and fluoropyrimidine chemotherapy. We use a wide breadth of structural, chemical, genetic and biophysical approaches that provide a fundamental understanding of molecular function. Our long-range goal is to use this understanding to design novel small molecules that alter biological pathways within a cellular environment. One approach we are developing is the high-throughput synthesis and screening of small molecule libraries directed at important targets in cancer and HIV-1 pathogenesis.

    Research Areas: biophysics, enzymes, cell biology, uracil, cancer, HIV, DNA, RNA

  • Supendymoma and Ependymoma Research Center

    The Johns Hopkins comprehensive Subependymoma and Ependymoma Research Center divideS its efforts into three areas: basic science, translational research and clinical practice. Each division works separately but shares findings and resources openly with each other and our collaborators. The goal of our united efforts is to optimize current treatments to affect the care received by patients with subependymomas and ependymomas. Also, our clinical, translational and basic science teams work to develop novel therapies to improve and extend the lives of those with these rare tumors.

    Research Areas: brain cancer

    Lab Website

    Principal Investigator

    Henry Brem, M.D.

    Department

    Neurosurgery

  • Susan Hutfless Lab

    The Susan Hutfless Lab uses administrative data to investigate epidemiologic questions about the causes of and treatments for chronic diseases, with a focus on gastrointestinal disorders. Our team has provided epidemiologic expertise to help design and analyze large-dataset studies of cervical cancer, colorectal cancer and mortality related to inflammatory bowel disease (IBD). We also have conducted research on infection-related triggers of Crohn’s disease in susceptible military personnel as well as prenatal and childhood predictors of pediatric-onset IBD.

    Research Areas: inflammatory bowel disease, Crohn’s disease, epidemiology, data analysis, maternal health, chronic disease, gastrointestinal

    Principal Investigator

    Susan Hutfless, Ph.D., S.M.

    Department

    Medicine

  • Suzanne Topalian Lab

    Our lab currently focuses on three areas of immunotherapy research: gaining a deeper knowledge of the biological underpinnings of human autoimmune response; discovering biomarkers that will help us identify which patients and tumor types are most likely to respond to various immune therapies; and developing immune-based treatment combinations that could deliver a more powerful anti-tumor response than monotherapies.

    Research Areas: cancer, PD-1, melanoma, immunotherapy, cancer immunology

    Principal Investigator

    Suzanne Topalian, M.D.

    Department

    Oncology

  • Sydney Dy Lab

    The Sydney Dy Lab has conducted extensive research on quality of care, patient safety and decision-making, with a focus on patients with cancer and other serious and terminal diseases. Our team seeks to improve health systems and services to optimize the use of technology and medication, particularly in end-of-life health care policy. Our research approach includes primary and quantitative data collection, quality measurement improvement, systematic literature reviews and analysis of secondary database.

    Research Areas: patient safety, palliative care, cancer, health care policy, pain, quality of care

    Lab Website

    Principal Investigator

    Sydney Dy, M.D.

    Department

    Medicine

  • Systems Biology Laboratory

    The Systems Biology Lab applies methods of multiscale modeling to problems of cancer and cardiovascular disease, and examines the systems biology of angiogenesis, breast cancer and peripheral artery disease (PAD).

    Using coordinated computational and experimental approaches, the lab studies the mechanisms of breast cancer tumor growth and metastasis to find ways to inhibit those processes.

    We use bioinformatics to discover novel agents that affect angiogenesis and perform in vitro and in vivo experiments to test these predictions. In addition we study protein networks that determine processes of angiogenesis, arteriogenesis and inflammation in PAD. The lab also investigates drug repurposing for potential applications as stimulators of therapeutic angiogenesis, examines signal transduction pathways and builds 3D models of angiogenesis.

    The lab has discovered over a hundred novel anti-angiogenic peptides, and has undertaken in vitro and in vivo studies testing their activity unde...r different conditions. We have investigated structure-activity relationship (SAR) doing point mutations and amino acid substitutions and constructed biomimetic peptides derived from their endogenous progenitors. They have demonstrated the efficacy of selected peptides in mouse models of breast, lung and brain cancers, and in age-related macular degeneration.

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    Research Areas: peripheral artery disease, breast cancer, systems biology, computational biology, cancer, cardiovascular, age-related macular degeneration, bioinformatics, angiogenesis, microcirculation

    Principal Investigator

    Aleksander Popel, Ph.D.

    Department

    Biomedical Engineering

  • The Burns Lab

    Our research laboratory studies the roles mobile DNAs play in human disease. Our group was one of the first to develop a targeted method for amplifying mobile DNA insertion sites in the human genome, and we showed that these are a significant source of structural variation (Huang et al., 2010). Since that time, our group has continued to develop high throughput tools to characterize these understudied sequences in genomes and to describe the expression and genetic stability of interspersed repeats in normal and malignant tissues. We have developed a monoclonal antibody to one of the proteins encoded for by Long INterspersed Element-1 (LINE-1) and showed its aberrant expression in a wide breadth of human cancers (Rodi? et al., 2014). We have demonstrated acquired LINE-1 insertion events during the evolution of metastatic pancreatic ductal adenocarcinoma and other gastrointestinal tract tumors (Rodi? et al., 2015). We have major projects focused on studying functional consequences of inh...erited sequence variants, and exciting evidence that these predispose to cancer risk and other disease phenotypes. Our laboratory is using a combination of genome wide association study (GWAS) analyses, custom RNA-seq analyses, semi-high throughput gene expression reporter assays, and murine models to pursue this hypothesis. view less

    Research Areas: cancer, DNA, malignant tumors

    Lab Website

    Principal Investigator

    Kathleen Burns, M.D., Ph.D.

    Department

    Pathology

  • The Howard and Georgeanna Seegar Jones Reproductive Endocrinology Lab

    Research in the Howard and Georgeanna Seegar Jones Reproductive Endocrinology Lab supports a broad interest in reproductive conditions, but has a particular focus on endometriosis, uterine fibroids, polycystic ovary syndrome (PCOS) and genes causing infertility. PCOS and uterine fibroids are among the most prevalent conditions leading to infertility and diseases in women, but both remain poorly understood. Studying these areas may lead to the development of new treatments or preventative therapies.

    Research Areas: uterine fibroids, endometriosis, genetics, infertility, polycystic ovarian syndrome, ovarian cancer

    Lab Website

    Principal Investigator

    James Segars, M.D.

    Department

    Gynecology and Obstetrics

  • The Meeker-Heaphy Lab

    Utilizing a combination of tissue-based, cell-based, and molecular approaches, our research goals focus on abnormal telomere biology as it relates to cancer initiation and tumor progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype. In addition, our laboratories focus on cancer biomarker discovery and validation with the ultimate aim to utilize these novel tissue-based biomarkers to improve individualized prevention, detection, and treatment strategies.

    Research Areas: preventing cancer metastasis, cancer, tumor cell metastasis

    Lab Website

    Principal Investigator

    Christopher Heaphy, Ph.D.

    Department

    Pathology

  • The Pathak Lab

    The Pathak lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. We develop novel imaging methods, computational models and visualization tools to ‘make visible’ critical aspects of cancer, stroke and neurobiology. Our research broadly encompasses the following areas: Functional and Molecular Imaging; Clinical Biomarker Development; Image-based Systems Biology and Visualization and Computational Tools. We are dedicated to mentoring the next generation of imagers, biomedical engineers and visualizers. Additional information can be found at www.pathaklab.org or by emailing Dr. Pathak.

    Research Areas: microscopy, vasculature, tumors, systems biology, functional magnetic resonance imaging, 3D imaging, biomarkers, optical imaging, angiogenesis, cancer imaging

  • The Sfanos Lab

    The Sfanos Lab studies the cellular and molecular pathology of prostate disease at the Johns Hopkins University School of Medicine. We are specifically interested in agents that may lead to chronic inflammation in the prostate, such as bacterial infections and prostatic concretions called corpora amylacea. Our ongoing studies are aimed at understanding the influence of prostate infections and inflammation on prostate disease including prostate cancer and benign prostatic hyperplasia (BPH). The laboratory also focuses on the influence of the microbiome on prostate disease development, progression, and/or resistance to therapy.

    Research Areas: disease resistance, prostate cancer, prostate, benign prostatic hyperplasia, prostate disease, chronic inflammation

    Lab Website

    Principal Investigator

    Karen Sfanos, M.S., Ph.D.

    Department

    Pathology

  • The Transplant and Oncology Infectious Diseases (TOID) Center

    The mission of the Transplant and Oncology Infectious Diseases (TOID) Center is to expand institutional expertise in clinical and academic activities focused on infectious complications in transplant (solid organ and stem cell) and oncology patients at Johns Hopkins medical institutions. Key efforts include developing standardized algorithms for the prevention and treatment of infections in these vulnerable patients and to establish an expanded infrastructure to facilitate clinical and translational studies at TOID. Current research projects focus on diagnostics for invasive fungal infections and specialized studies of the pathogenesis of candidiasis and aspergillosis.

    Research Areas: transplants, candidiasis, fungal infections, infectious disease, cancer, aspergillosis

    Lab Website

    Principal Investigator

    Kieren Marr, M.D.

    Department

    Medicine

  • Victor Velculescu Lab

    The lab currently focuses on identifying genetic alterations in cancer affecting sensitivity and resistance to targeted therapies, and connecting such changes to key clinical characteristics and novel therapeutic approaches. We have recently developed methods that allow noninvasive characterization of cancer, including the PARE method that provided the first whole genome analysis of tumor DNA in the circulation of cancer patients. These analyses provide a window into real-time genomic analyses of cancer patients and provide new avenues for personalized diagnostic and therapeutic intervention.

    Research Areas: cancer, genomics, immunotherapy

  • William B. Isaacs Laboratory

    Prostate cancer is the most commonly diagnosed malignancy in men in the United States, although our understanding of the molecular basis for this disease remains incomplete. We are interested in characterizing consistent alterations in the structure and expression of the genome of human prostate cancer cells as a means of identifying genes critical in the pathways of prostatic carcinogenesis.

    We are focusing on somatic genomic alterations occurring in sporadic prostate cancers, as well as germline variations which confer increases in prostate cancer risk. Both genome wide and candidate gene approaches are being pursued, and cancer associated changes in gene expression analyses of normal and malignant prostate cells are being cataloged as a complementary approach in these efforts.

    It is anticipated that this work will assist in providing more effective methodologies to identify men at high risk for this disease, in general, and in particular, to identify new markers of prognostic... and therapeutic significance that could lead to more effective management of this common disease. view more

    Research Areas: cell biology, prostate cancer, molecular genetics

    Lab Website

    Principal Investigator

    William Isaacs, Ph.D.

    Department

    Urology

  • William G. Nelson Laboratory

    Normal and neoplastic cells respond to genome integrity threats in a variety of different ways. Furthermore, the nature of these responses are critical both for cancer pathogenesis and for cancer treatment. DNA damaging agents activate several signal transduction pathways in damaged cells which trigger cell fate decisions such as proliferation, genomic repair, differentiation, and cell death. For normal cells, failure of a DNA damaging agent (i.e., a carcinogen) to activate processes culminating in DNA repair or in cell death might promote neoplastic transformation. For cancer cells, failure of a DNA damaging agent (i.e., an antineoplastic drug) to promote differentiation or cell death might undermine cancer treatment.

    Our laboratory has discovered the most common known somatic genome alteration in human prostatic carcinoma cells. The DNA lesion, hypermethylation of deoxycytidine nucleotides in the promoter of a carcinogen-defense enzyme gene, appears to result in inactivation of th...e gene and a resultant increased vulnerability of prostatic cells to carcinogens.
    Studies underway in the laboratory have been directed at characterizing the genomic abnormality further, and at developing methods to restore expression of epigenetically silenced genes and/or to augment expression of other carcinogen-defense enzymes in prostate cells as prostate cancer prevention strategies.

    Another major interest pursued in the laboratory is the role of chronic or recurrent inflammation as a cause of prostate cancer. Genetic studies of familial prostate cancer have identified defects in genes regulating host inflammatory responses to infections.
    A newly described prostate lesion, proliferative inflammatory atrophy (PIA), appears to be an early prostate cancer precursor. Current experimental approaches feature induction of chronic prostate inflammation in laboratory mice and rats, and monitoring the consequences on the development of PIA and prostate cancer.
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    Research Areas: cellular biology, cancer, epigenetics, DNA

    Lab Website

    Principal Investigator

    William Nelson, M.D., Ph.D.

    Department

    Oncology

  • Youngjee Choi Lab

    Research in the Youngjee Choi Lab focuses on ambulatory care, cancer survivorship, high-value care and medical education.

    Research Areas: medical education, ambulatory care, cancer survivors

    Principal Investigator

    Youngjee Choi, M.D.

    Department

    Medicine

  • Zambidis Laboratory

    The Zambidis Labratory studies the formation of pluripotent stem cells and the subsequent hematopoietic, endothelial and cardiac differentiation, as well as the potential therapeutic uses of pluripotent stem cell-derived cells.

    Research Areas: stem cells, vasculogenesis, cardiogenesis, hematopoiesis, cancer stem cells, pluripotency

    Principal Investigator

    Elias Zambidis, M.D., Ph.D.

    Department

    Oncology

  • Zaver M. Bhujwalla Lab – Cancer Imaging Research

    Dr. Bhujwalla’s lab promotes preclinical and clinical multimodal imaging applications to understand and effectively treat cancer. The lab’s work is dedicated to the applications of molecular imaging to understand cancer and the tumor environment. Significant research contributions include 1) developing ‘theranostic agents’ for image-guided targeting of cancer, including effective delivery of siRNA in combination with a prodrug enzyme 2) understanding the role of inflammation and cyclooxygenase-2 (COX-2) in cancer using molecular and functional imaging 3) developing noninvasive imaging techniques to detect COX-2 expressing in tumors 4) understanding the role of hypoxia and choline pathways to reduce the stem-like breast cancer cell burden in tumors 5) using molecular and functional imaging to understand the role of the tumor microenvironment including the extracellular matrix, hypoxia, vascularization, and choline phospholipid metabolism in prostate and breast cancer invasion and metast...asis, with the ultimate goal of preventing cancer metastasis and 6) molecular and functional imaging characterization of cancer-induced cachexia to understand the cachexia-cascade and identify novel targets in the treatment of this condition. view less

    Research Areas: molecular and functional imaging, preventing cancer metastasis, metastasis, image-guided targeting of cancer, cancer-induced cachexia, cancer imaging

  • Zhu Lab

    The Zhu lab is focused on characterizing the activities of large collection of proteins, building signaling networks for better understanding the mechanisms of biological processes, and identifying biomarkers in human diseases and cancers.

    More specifically, our group is interested in analyzing protein posttranslational modifications, and identifying important components involved in transcription networks and host-pathogen interactions on the proteomics level, and biomarkers in human IBD diseases.

    Research Areas: proteomics, biomarkers, cancer, genomics, protein chip, signaling networks

    Principal Investigator

    Heng Zhu, Ph.D.

    Department

    Pharmacology and Molecular Sciences

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