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  • Dmitri Artemov Lab

    The Artemov lab is within the Division of Cancer Imaging Research in the Department of Radiolog...y and Radiological Science. The lab focuses on 1) Use of advanced dynamic contrast enhanced-MRI and activated dual-contrast MRI to perform image-guided combination therapy of triple negative breast cancer and to assess therapeutic response. 2) Development of noninvasive MR markers of cell viability based on a dual-contrast technique that enables simultaneous tracking and monitoring of viability of transplanted stems cells in vivo. 3) Development of Tc-99m and Ga-68 angiogenic SPECT/PET tracers to image expression of VEGF receptors that are involved in tumor angiogenesis and can be important therapeutic targets. 4) Development of the concept of “click therapy” that combines advantages of multi-component targeting, bio-orthogonal conjugation and image guidance and preclinical validation in breast and prostate cancer models. view more

    Research Areas: VEGF receptors image expression, SPECT/PET tracers, tracking stem cells in vivo, triple-negative breast cancer, image-guided combination therapy, MRI, noninvasive MR markers, cancer imaging
  • Douglas Ball Lab

    Principal Investigator:
    Douglas Ball, M.D.
    Medicine

    The Douglas Ball Lab conducts clinical trials and pre-clinical laboratory studies of thyroid ca...ncer. Our clinical trials, performed in collaboration with research staff in the upper aero-digestive group in the Sidney Kimmel Comprehensive Cancer Center, have included protocols for advanced radioiodine-refractory differentiated thyroid cancer and medullary thyroid cancer. Our pre-clinical research, conducted with Dr. Nelkin, Dr. Agrawal and other Kimmel Cancer Center researchers, includes pathogenesis and mechanisms of treatment resistance in medullary thyroid cancer, and pathogenesis and immune-directed therapy of anaplastic thyroid cancer. view more

    Research Areas: thyroid cancer, medullary thyroid cancer, cancer, anaplastic thyroid cancer
  • Drew Pardoll Lab

    The Pardoll Lab focuses on the regulation of antigen-specific T cell responses and studies appr...oaches to modify these responses for immunotherapy. Pardoll has a particular interest in cancer immunology and his lab’s studies on basic immunologic mechanisms have led to the development and design of a number of cancer vaccines and discovery of key checkpoint ligands and receptors, such as PD-L2, LAG-3 and neuritin, many of which are being targeted clinically.

    Our primary pursuits are discovering and elucidating new molecules that regulate immune responses, investigating the biology of regulatory T cells, and better understanding the specific biochemical signatures that allow a patient’s T cells to selectively target cancer cells.
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    Research Areas: tumor antigens, cancer, immunotherapy, regulatory T cells, T cells
  • Drug Discovery Group

    Lab Website
    Principal Investigator:
    Barbara Slusher, Ph.D., M.A.S.
    Oncology

    Barbara Slusher, M.A.S., Ph.D., leads a 20-member veteran drug discovery team of medicinal chem...ists, assay developers, pharmacologists, toxicologists and pharmacokinetic/drug metabolism experts, who identify novel drug targets arising from JHU faculty’s research and translate them into new, small molecule drug therapies.

    Her team collaborates extensively with faculty at the Bloomberg~Kimmel Institute for Cancer Immunotherapy and leads the BKI immunotherapy drug discovery core, aimed at developing new immune-targeting drug therapies for laboratory and clinical testing at Johns Hopkins.
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    Research Areas: glutamine antagonist, drug discovery, cancer, immunotherapy, cancer metabolism
  • Early Detection of Pancreatic Cancer Laboratory

    Lab Website
    Principal Investigator:
    Michael Goggins, M.B.B.Ch., M.D.
    Medicine

    The goal of the lab's research is to identify molecular abnormalities that can improve the outc...ome of patients with pancreatic cancer and those at risk of developing this disease. Much of our work is focused on translational research evaluating markers and marker technologies that can help screen patients with an increased risk of developing pancreatic cancer.

    Thus, marker efforts have been focused mostly on identifying markers of advanced precancerous neoplasia (PanINs and IPMNs) that could improve our ability to effectively screen patients at risk of developing pancreatic cancer. We lead or participate in a number of clinical research protocols involved in the screening and early detection of pancreatic neoplasia including the CAPS clinical trials. We maintain a large repository of specimens from cases and controls with and without pancreatic disease and use this repository to investigate candidate markers of pancreatic cancer for their utility to predict pancreatic cancer risk.

    In addition, we have been working to identify familial pancreatic cancer susceptibility genes and identified BRCA2 as a pancreatic cancer susceptibility gene in 1996. We participate in the PACGENE consortium and the familial pancreatic cancer sequencing initiative. My lab also investigates pancreatic cancer genetics, epigenetics, molecular pathology, tumor stromal interactions and functional analysis of candidate genes and miRNAs. Dr. Goggins is the principal investigator of a phase I/II clinical trial evaluating the Parp inhibitor, olaparib along with irinotecan and cisplatin for patients with pancreatic cancer.
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    Research Areas: pancreatic cancer
  • Eberhart, Rodriguez and Raabe Lab

    Lab Website
    Principal Investigator:
    Charles Eberhart, M.D., Ph.D.
    Pathology

    Utilizing a combination of tissue-based, cell-based, and molecular approaches, our research goa...ls focus on abnormal telomere biology as it relates to cancer initiation and tumor progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype. In addition, our laboratories focus on cancer biomarker discovery and validation with the ultimate aim to utilize these novel tissue-based biomarkers to improve individualized prevention, detection, and treatment strategies. view more

    Research Areas: cancer therapies, preventing cancer metastasis, cancer, cancer biomarkers
  • Eberhart, Rodriguez and Raabe Lab

    Lab Website
    Principal Investigator:
    Charles Eberhart, M.D., Ph.D.
    Pathology

    Utilizing a combination of tissue-based, cell-based, and molecular approaches, our research goa...ls focus on abnormal telomere biology as it relates to cancer initiation and tumor progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype. In addition, our laboratories focus on cancer biomarker discovery and validation with the ultimate aim to utilize these novel tissue-based biomarkers to improve individualized prevention, detection, and treatment strategies.
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    Research Areas: stem cells, eye tumor, tumor cell metastasis, brain tumor
  • Elizabeth M. Jaffee, M.D.

    Lab Website
    Principal Investigator:
    Elizabeth Jaffee, M.D.
    Oncology

    Current projects include:

    The evaluation of mechanisms of immune tolerance to cancer in m...ouse models of breast and pancreatic cancer. We have characterized the HER-2/neu transgenic mouse model of spontaneous mammary tumors.
    This model demonstrates immune tolerance to the HER-2/neu gene product. This model is being used to better understand the mechanisms of tolerance to tumor. In addition, this model is being used to develop vaccine strategies that can overcome this tolerance and induce immunity potent enough to prevent and treat naturally developing tumors. More recently, we are using a genetic model of pancreatic cancer developed to understand the early inflammatory changes that promote cancer development.

    The identification of human tumor antigens recognized by T cells. We are using a novel functional genetic approach developed in our laboratory. Human tumor specific T cells from vaccinated patients are used to identify immune relevant antigens that are chosen based on an initial genomic screen of overexpressed gene products. Several candidate targets have been identified and the prevelence of vaccine induced immunity has been assessed .
    This rapid screen to identify relevant antigenic targets will allow us to begin to dissect the mechanisms of tumor immunity induction and downregulation at the molecular level in cancer patients. More recently, we are using proteomics to identify proteins involved in pancreatic cancer development. We recently identified Annexin A2 as a molecule involved in metastases.

    The analysis of antitumor immune responses in patients enrolled on vaccine studies. The focus is on breast and pancreatic cancers. We are atttempting to identify in vitro correlates of in vivo antitumor immunity induced by vaccine strategies developed in the laboratory and currently under study in the clinics.
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    Research Areas: immunology, cancer, anti-cancer drugs
  • Eugene Shenderov Laboratory

    Lab Website
    Principal Investigator:
    Eugene Shenderov, M.D., Ph.D.
    Oncology

    The Shenderov Lab focuses on the elucidation of the mechanisms of immune response and resistanc...e to immunotherapy in Prostate Cancer. This has led to clinical and basic research investigating the presumptive checkpoint inhibitor B7-H3.

    In pursuit of understanding biomarkers or resistance and response, and regulatory molecules of immune response, we utilize artificial intelligence, immunogenomics, and spatial proteomics and transcriptomics in the laboratory and at the bedside using clinical trial correlative samples.
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    Research Areas: Cancer Immunotherapy, tumor antigens, prostate cancer, Immunogenomics, artificial intelligence, Spatialomics, B7-H3
  • Fisher Biomarker Research Laboratory

    Principal Investigator:
    Alan Partin, M.D., Ph.D.
    Urology

    The Veltri-Partin Fisher Biomarker Laboratory strives to improve the early detection, staging, ...monitoring and prognosis of prostate cancer and other urologic cancers with the use of biomarkers. view more

    Research Areas: prostate cancer, biomarkers, urologic cancers
  • Florin Selaru Lab

    Principal Investigator:
    Florin Selaru, M.D.
    Medicine

    Research interests in the Florin Selaru Lab comprise the molecular changes associated with the ...transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract. view more

    Research Areas: gastroenterology, cancer, inflammation, molecular biology
  • Follow the Leader: Specialized Cancer Cells Lead Collective Invasion (Ewald Lab)

    Lab Website
    Principal Investigator:
    Andrew Ewald, Ph.D.
    Cell Biology

    Research in the Ewald laboratory starts from a simple question: Which cells in a breast tumor a...re the most dangerous to the patient and most responsible for metastatic disease? To answer this question, we developed novel 3-D culture assays to allow real-time analysis of invasion. Our data reveal that K14+ cancer cells play a central role in metastatic disease and suggest that the development of clinical strategies targeting these cells will provide novel breast cancer treatments. view more

    Research Areas: breast cancer, cellular biology, molecular biology
  • Francis Giardiello Lab

    Principal Investigator:
    Francis Giardiello, M.D.
    Medicine

    Research in the Francis Giardiello Lab focuses on the study of cancer and cancer chemopreventio...n in the gastrointestinal tract. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. We have a continuing interest in the study of the genotypic-phenotypic correlations in polyposis syndromes, which include familial adenomatous polyposis, juvenile polyposis and Peutz-Jeghers syndrome. view more

    Research Areas: gastrointestinal system, colorectal cancer, cancer, genomics, polyposis syndromes
  • Franck Housseau Lab

    Principal Investigator:
    Franck Housseau, Ph.D.
    Oncology

    The Franck Housseau Lab focuses on the role of the microbiome in colorectal tumorigenesis and o...n developing a better understanding of the tumor immune microenvironment. The lab is currently working to define the biomarkers of a pre-existing antitumor immune response in metastatic colorectal cancer to define a population of patients eligible for checkpoint blockade therapies. view more

    Research Areas: microbiology, tumor immunology, microbiome, colorectal cancer, cancer, colon cancer, tumor microenvironment, immunotherapy
  • GI Biomarkers Laboratory

    Lab Website
    Principal Investigator:
    Stephen Meltzer, M.D.
    Medicine

    The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biom...arkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches. view more

    Research Areas: gastrointestinal system, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis
  • GI Early Detection Biomarkers Lab

    Principal Investigator:
    Stephen Meltzer, M.D.
    Medicine

    Dr. Meltzer is an internationally renowned leader in the molecular pathobiology of gastrointest...inal malignancy and premalignancy. He invented molecular methods to detect loss of heterozygosity in tiny biopsies, triggering an avalanche of research on precancerous lesions. He was the first to comprehensively study coding region microsatellite instability, leading to the identification of several important tumor suppressor genes. He performed several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the GI research paradigm toward genome-wide approaches. He directed an ambitious nationwide validation study of DNA methylation-based biomarkers for the prediction of neoplastic progression in Barrett’s esophagus.

    Dr. Meltzer founded and led the Aerodigestive Cancer and Biomarker Interdisciplinary Programs at the University of Maryland, also becoming associate director for core sciences at that school’s Cancer Center. He currently holds an endowed professorship and is the director of GI biomarker research at Johns Hopkins.

    The laboratory group focuses its efforts on the molecular genetics of gastrointestinal cancers and premalignant lesions, as well as on translational research to improve early detection, prognostic evaluation, and treatment of these conditions. Below, some examples of this work are described.
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    Research Areas: gastrointestinal cancer, gastrointestinal
  • Gilkes Lab

    Principal Investigator:
    Daniele Gilkes, Ph.D.
    Oncology

    Our lab is focused on determining the role of hypoxia in breast cancer metastasis. We are parti...cularly interested in the changes in the extracellular matrix that occur under hypoxic conditions and promote cancer cell migration. view more

    Research Areas: breast cancer, HIF-1, hypoxia, ECM
  • Grant (Xuguang) Tao Lab

    Principal Investigator:
    Grant Tao, M.D., Ph.D., M.S.
    Medicine

    Research in the Grant (Xuguang) Tao Lab explores environmental and occupational epidemiology to...pics, including workers' compensation and injuries, and nosocomial infections. We conduct research through clinical trials and systematic literature reviews, and also use cancer registry data and GIS applications in environmental epidemiological research. Our recent studies have explored topics such as the effectiveness of lumbar epidural steroid injections following lumbar surgery, the effect of physician-dispensed medication on workers' compensation claim outcomes and how the use of opioid and psychotropic medications for workers' compensation claims impacts lost work time. view more

    Research Areas: epidemiology, drug safety, cancer, nosocomial infections, GIS applications
  • Gregg Semenza Lab

    Principal Investigator:
    Gregg Semenza, M.D., Ph.D.
    Pediatrics

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned an...d characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.
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    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia
  • Gregory Kirk Lab

    Research in the Gregory Kirk Lab examines the natural history of viral infections — particularl...y HIV and hepatitis viruses — in the U.S. and globally. As part of the ALIVE (AIDS Linked to the Intravenous Experience) study, our research looks at a range of pathogenetic, clinical behavioral issues, with a special focus on non-AIDS-related outcomes of HIV, including cancer and liver and lung diseases. We use imaging and clinical, genetic, epigenetic and proteomic methods to identify and learn more about people at greatest risk for clinically relevant outcomes from HIV, hepatitis B and hepatitis C infections. Our long-term goal is to translate our findings into targeted interventions that help reduce the disease burden of these infections. view more

    Research Areas: global health, Hepatitis, Africa, AIDS, cancer, HIV, drugs, liver diseases
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