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Research Lab Results for cancer

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  • Kenneth J. Pienta Lab

    Lab Website
    Principal Investigator:
    Kenneth Pienta, M.D.
    Urology

    The Kenneth J. Pienta laboratory has championed the concept that cancer tumorigenesis and metas...tasis can best be understood utilizing the principles of Ecology. As a result, the Pienta laboratory is working to develop new treatments for cancer utilizing network disruption. view more

    Research Areas: biomarkers, cancer, metastasis
  • Kenneth W. Kinzler Laboratory

    Lab Website
    Principal Investigator:
    Kenneth Kinzler, Ph.D.
    Oncology

    Dr. Kinzler’s laboratory has focused on the genetics of human cancer. They have identified a va...riety of genetic mutations that underlie cancer, including mutations of the APC pathway that appear to initiate the majority of colorectal cancers and IDH1/2 mutations that underlying many gliomas. In addition, they have developed a variety of powerful tools for analysis of expression and genetic alterations in cancer.
    Most recently, they have pioneered integrated whole genome analyses of human cancers through expression, copy number, and mutational analyses of all the coding genes in several human cancer types including colorectal, breast, pancreatic and brain. The identification of genetic differences between normal and tumor tissues provide new therapeutic targets, new opportunities for the early diagnosis of cancer, and important insights into the neoplastic process.
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    Research Areas: cancer, molecular genetics
  • Komatsu Lab

    Malfunction and malformation of blood vessels are associated with a broad range of medical cond...itions, including cancer, cardiovascular diseases, and neurological disorders. The ultimate goal of the Komatsu lab is to find a way to reverse the process of abnormal vessel formation and restore normal function to these vessels. In cancer, normalization of tumor blood vessels facilitates lymphocyte infiltration, potentiating anti-tumor immunity, and enhances the efficacy of immunotherapies as well as conventional cancer treatments. Normalization of regenerating blood vessels is also necessary for reestablishing blood flow to ischemic hearts and limbs, and preventing blindness caused by diabetic retinopathy or macular degeneration. Komatsu lab’s research is uncovering key molecular pathways important for the normalization of pathological vasculature. view more

    Research Areas: Tertiary lymphoid structure (TLS) in cancer, Drug targeting, High endothelial venules and their role in lymphocyte recruitment, Vascular normalization
  • Konig Lab

    Principal Investigator:
    Maximilian Konig, M.D.
    Medicine

    The Konig Lab focuses on chimeric T cell- and antibody-based strategies for the treatment of au...toimmune rheumatic diseases and cancer. A primary goal of the translational research program is the development of antigen-specific and personalized immunotherapies for autoimmune diseases, with the intent to achieve sustained disease remission and functional cure. The lab further aims to establish precision T cell-targeting therapies for the treatment of various autoimmune diseases. Applying these tools to immuno-oncology, the lab utilizes cellular engineering strategies to augment the cytotoxic killing of solid cancers by the immune system. view more

    Research Areas: antigen-specific immunotherapy, myositis, autoimmunity, citrullination, rheumatology, antiphospholipid antibody syndrome, chimeric antigen receptor (CAR) T cell therapy, immuno-oncology, autoimmune rheumatic diseases, rheumatoid arthritis
  • Kristine Glunde Lab

    Lab Website

    The Glunde lab is within the Division of Cancer Imaging Research in the Department of Radiology... and Radiological Science. The lab is developing mass spectrometry imaging as part of multimodal molecular imaging workflows to image and elucidate hypoxia-driven signaling pathways in breast cancer. They are working to further unravel the molecular basis of the aberrant choline phospholipid metabolism in cancer. The Glunde lab is developing novel optical imaging agents for multi-scale molecular imaging of lysosomes in breast tumors and discovering structural changes in Collagen I matrices and their role in breast cancer and metastasis. view more

    Research Areas: breast cancer, mass spectrometry, imaging, cancer, metastasis, metabolism, optical imaging
  • Lei Zheng Lab

    Lab Website
    Principal Investigator:
    Lei Zheng, M.D., Ph.D.
    Oncology
    Surgery

    Zheng’s research focuses on two R01-funded projects; first, the group has developed a pancreati...c cancer immunotherapy research program on a neoadjuvant therapy platform as well as a number of preclinical models of pancreatic cancer for developing innovative immunotherapy strategies. The group has applied the knowledge gained from pancreatic cancer immune-based therapies to the development of a colorectal cancer GVAX vaccine. Second, the group is aimed at understanding the mechanistic roles of the tumor microenvironment in cancer development and metastasis and identifying new targets for pancreatic cancer therapies by dissecting the tumor microenvironment of pancreatic cancer. view more

    Research Areas: cancer, pancreatic cancer, translational research, tumor microenvironment, immunotherapy
  • Linda Smith-Resar Lab

    Lab Website
    Principal Investigator:
    Linda Smith Resar, M.D.
    Medicine

    The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanism...s that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention. view more

    Research Areas: blood disorders, sickle cell diseases, blood management programs, hematologic malignancies
  • Lonny Yarmus Lab

    Principal Investigator:
    Lonny Yarmus, D.O.
    Medicine

    Clinical trials conducted in the Lonny Yarmus Lab focus primarily on minimally-invasive diagnos...tic testing for patients with lung cancer and local therapy options for malignant airway obstructions. We investigate ways to improve the early diagnosis of lung cancer, as well as the treatment of later-stage cancer, using the least invasive methods possible. We are also part of the LIBERATE clinical study for patients who have difficulty breathing and suffer from severe emphysema. view more

    Research Areas: emphysema, interventional pulmonology, airway stenosis, minimally-invasive diagnostic testing, lung cancer, central airway obstructions, lung transplant
  • Machine Biointerface Lab

    Lab Website

    Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medic...al Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.

    Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.

    Medical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
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    Research Areas: medical instruments, bioelectricities, neuroengineering, nerve stimulation
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