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Research Lab Results for cancer

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  • Eugene Shenderov Laboratory

    Lab Website
    Principal Investigator:
    Eugene Shenderov, M.D., Ph.D.
    Oncology

    The Shenderov Lab focuses on the elucidation of the mechanisms of immune response and resistanc...e to immunotherapy in Prostate Cancer. This has led to clinical and basic research investigating the presumptive checkpoint inhibitor B7-H3.

    In pursuit of understanding biomarkers or resistance and response, and regulatory molecules of immune response, we utilize artificial intelligence, immunogenomics, and spatial proteomics and transcriptomics in the laboratory and at the bedside using clinical trial correlative samples.
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    Research Areas: Cancer Immunotherapy, tumor antigens, prostate cancer, Immunogenomics, artificial intelligence, Spatialomics, B7-H3
  • Florin Selaru Lab

    Principal Investigator:
    Florin Selaru, M.D.
    Medicine
    Oncology

    Research interests in the Florin Selaru Lab comprise the molecular changes associated with the ...transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract. view more

    Research Areas: gastroenterology, cancer, inflammation, molecular biology
  • Follow the Leader: Specialized Cancer Cells Lead Collective Invasion (Ewald Lab)

    Lab Website
    Principal Investigator:
    Andrew Ewald, Ph.D.
    Cell Biology

    Research in the Ewald laboratory starts from a simple question: Which cells in a breast tumor a...re the most dangerous to the patient and most responsible for metastatic disease? To answer this question, we developed novel 3-D culture assays to allow real-time analysis of invasion. Our data reveal that K14+ cancer cells play a central role in metastatic disease and suggest that the development of clinical strategies targeting these cells will provide novel breast cancer treatments. view more

    Research Areas: breast cancer, cellular biology, molecular biology
  • Franck Housseau Lab

    Principal Investigator:
    Franck Housseau, Ph.D.
    Oncology

    The Franck Housseau Lab focuses on the role of the microbiome in colorectal tumorigenesis and o...n developing a better understanding of the tumor immune microenvironment. The lab is currently working to define the biomarkers of a pre-existing antitumor immune response in metastatic colorectal cancer to define a population of patients eligible for checkpoint blockade therapies. view more

    Research Areas: microbiology, tumor immunology, microbiome, colorectal cancer, cancer, colon cancer, tumor microenvironment, immunotherapy
  • GI Biomarkers Laboratory

    Principal Investigator:
    Stephen Meltzer, M.D.
    Medicine
    Oncology

    The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biom...arkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches. view more

    Research Areas: gastrointestinal system, translational research in Barrett’s esophagus-associated neoplastic progression, Molecular pathophysiology, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis
  • GI Early Detection Biomarkers Lab

    Principal Investigator:
    Stephen Meltzer, M.D.
    Medicine

    Dr. Meltzer is an internationally renowned leader in the molecular pathobiology of gastrointest...inal malignancy and premalignancy. He invented molecular methods to detect loss of heterozygosity in tiny biopsies, triggering an avalanche of research on precancerous lesions. He was the first to comprehensively study coding region microsatellite instability, leading to the identification of several important tumor suppressor genes. He performed several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the GI research paradigm toward genome-wide approaches. He directed an ambitious nationwide validation study of DNA methylation-based biomarkers for the prediction of neoplastic progression in Barrett’s esophagus.

    Dr. Meltzer founded and led the Aerodigestive Cancer and Biomarker Interdisciplinary Programs at the University of Maryland, also becoming associate director for core sciences at that school’s Cancer Center. He currently holds an endowed professorship and is the director of GI biomarker research at Johns Hopkins.

    The laboratory group focuses its efforts on the molecular genetics of gastrointestinal cancers and premalignant lesions, as well as on translational research to improve early detection, prognostic evaluation, and treatment of these conditions. Below, some examples of this work are described.
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    Research Areas: gastrointestinal cancer, gastrointestinal
  • Gilkes Lab

    Principal Investigator:
    Daniele Gilkes, Ph.D.
    Oncology

    Our lab is focused on determining the role of hypoxia in breast cancer metastasis. We are parti...cularly interested in the changes in the extracellular matrix that occur under hypoxic conditions and promote cancer cell migration. view more

    Research Areas: breast cancer, HIF-1, hypoxia, ECM
  • Grant (Xuguang) Tao Lab

    Principal Investigator:
    Grant Tao, M.D., Ph.D., M.S.
    Medicine

    Research in the Grant (Xuguang) Tao Lab explores environmental and occupational epidemiology to...pics, including workers' compensation and injuries, and nosocomial infections. We conduct research through clinical trials and systematic literature reviews, and also use cancer registry data and GIS applications in environmental epidemiological research. Our recent studies have explored topics such as the effectiveness of lumbar epidural steroid injections following lumbar surgery, the effect of physician-dispensed medication on workers' compensation claim outcomes and how the use of opioid and psychotropic medications for workers' compensation claims impacts lost work time. view more

    Research Areas: epidemiology, drug safety, cancer, nosocomial infections, GIS applications
  • Gregg Semenza Lab

    Principal Investigator:
    Gregg Semenza, M.D., Ph.D.
    Pediatrics

    The Gregg Semenza Lab studies the molecular mechanisms of oxygen homeostasis. We have cloned an...d characterized hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription factor.

    Current research investigates the role of HIF-1 in the pathophysiology of cancer, cerebral and myocardial ischemia, and chronic lung disease, which are the most common causes of mortality in the U.S.
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    Research Areas: cancer, oxygen, lung disease, genomics, HIF-1, pathogenesis, myocardial ischemia
  • Gregory Kirk Lab

    Research in the Gregory Kirk Lab examines the natural history of viral infections — particularl...y HIV and hepatitis viruses — in the U.S. and globally. As part of the ALIVE (AIDS Linked to the Intravenous Experience) study, our research looks at a range of pathogenetic, clinical behavioral issues, with a special focus on non-AIDS-related outcomes of HIV, including cancer and liver and lung diseases. We use imaging and clinical, genetic, epigenetic and proteomic methods to identify and learn more about people at greatest risk for clinically relevant outcomes from HIV, hepatitis B and hepatitis C infections. Our long-term goal is to translate our findings into targeted interventions that help reduce the disease burden of these infections. view more

    Research Areas: global health, Hepatitis, Africa, AIDS, cancer, HIV, drugs, liver diseases
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