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Displaying 51 to 60 of 93 results for brain

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  • Lee Martin Laboratory

    In the Lee Martin Laboratory, we are testing the hypothesis that selective vulnerability--the phenomenon in which only certain groups of neurons degenerate in adult onset neurological disorders like amyotrophic lateral sclerosis and Alzheimer's disease--is dictated by brain regional connectivity, mitochondrial function and oxidative stress. We believe it is mediated by excitotoxic cell death resulting from abnormalities in excitatory glutamatergic signal transduction pathways, including glutamate transporters and glutamate receptors as well as their downstream intracellular signaling molecules.

    We are also investigating the contribution of neuronal/glial apoptosis and necrosis as cell death pathways in animal (including transgenic mice) models of acute and progressive neurodegeneration. We use a variety of anatomical and molecular neurobiological approaches, including neuronal tract-tracing techniques, immunocytochemistry, immunoblotting, antipeptide antibody production, transmissi...on electron microscopy and DNA analysis to determine the precise regional and cellular vulnerabilities and the synaptic and molecular mechanisms that result in selective neuronal degeneration.
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    Research Areas: ALS, neurodegeneration, selective vulnerability, cell death, Alzheimer's disease

    Lab Website

    Principal Investigator

    Lee Martin, Ph.D.

    Department

    Pathology

  • Loyal Goff Laboratory

    The Loyal Goff Laboratory seeks to answer a fundamental biological question: How is the genome properly interpreted to coordinate the diversity of cell types observed during neuronal development? We are focused on the acquisition of specific cellular identities in neuronal development and identifying the molecular determinants responsible for proper brain development. Using novel experimental approaches for the enrichment and purification of specific neuronal cell types and recent technological advances in single-cell RNA sequencing, we can discover and explore the cellular factors that contribute to neuronal cell fate decisions during mammalian brain development.

    Research Areas: brain, neuronal development, genomics, RNA

    Lab Website

    Principal Investigator

    Loyal Goff, Ph.D.

    Department

    Neuroscience

  • Machine Biointerface Lab

    Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medical Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.

    Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.

    M...edical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
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    Research Areas: medical instruments, bioelectricities, neuroengineering, nerve stimulation

  • Marshall Shuler Laboratory

    The Marshall Shuler Laboratory aims to understand the means by which brain reward systems convey reward value, expectancy, quality, probability and utility, and the rules by which such activity is used to affect synaptic weight within brain networks to encode stimulus-action associations. We use an interdisciplinary approach combining multisite recordings of neural activity, targeted pharmacological manipulation, viral-mediated gene transfer and behavior to study the neural mechanisms of reward-based interval learning in the primary visual cortex.

    Research Areas: neural circuits, reward-based systems, brain, vision, pharmacology

    Lab Website

    Principal Investigator

    Marshall Shuler, Ph.D.

    Department

    Neuroscience

  • Marvel Cognitive Neuropsychiatric Research Laboratory

    The Cognitive Neuropsychiatric Research Laboratory (CNRLab) is part of the Division of Cognitive Neuroscience within the Department of Neurology at the Johns Hopkins University School of Medicine. Its current projects include investigating the motor system's contribution to cognitive function; HIV-related neuroplasticity and attention-to-reward as predictors of real world function; and brain function and cognition in Lyme disease.

    Research Areas: HIV, neuroplasticity, movement disorders, cognitive function

    Lab Website

    Principal Investigator

    Cherie Marvel, Ph.D.

    Department

    Neurology

  • Minimally Invasive Neurosurgery Lab

    Directed by Alan R. Cohen, M.D., Carson-Spiro Professor of Neurosurgery, Oncology and Pediatrics, the laboratory is focused on developing novel instruments and approaches to enhance the safety and efficacy of neurosurgical procedures. Current investigations include work in microsurgery, endoscopy, image guidance and robotic surgery. A cadaveric skills lab offers training in neurosurgical techniques.

    Research Areas: brain tumor surgery, minimally invasive surgery, brain tumor

    Lab Website

    Principal Investigator

    Alan Cohen, M.D.

    Department

    Neurology
    Neurosurgery

  • Mollie Meffert Lab

    The Mollie Meffert Lab studies mechanisms underlying enduring changes in brain function. We are interested in understanding how programs of gene expression are coordinated and maintained to produce changes in synaptic, neuronal and cognitive function. Rather than concentrating on single genes, our research is particularly focused on understanding the upstream processes that allow neuronal stimuli to synchronously orchestrate both up and down-regulation of the many genes required to mediate changes in growth and excitation. This process of gene target specificity is implicit to the appropriate production of gene expression programs that control lasting alterations in brain function.

    Research Areas: cognition, neuronal function, synaptic function, brain, genomics

  • Motion Analysis Laboratory

    Our team is focused on understanding how complex movements are normally learned and controlled, and how damage to specific brain areas impairs these processes. We employ several techniques to quantify movement including: 3-dimensional tracking and reconstruction of movement, recordings of muscle activity, force plate recordings, and calculation of joint forces and torques. These techniques allow for very precise measurements of many different types of movements including: walking, reaching, leg movements, hand movements and standing balance. All studies are designed to test specific hypotheses about the function of different brain areas, the cause of specific impairments and/or the effects of different interventions.

    Research Areas: cerebellar function, neurological diseases, motor learning

  • Neuroengineering and Biomedical Instrumentation Lab

    The mission and interest of the neuroengineering and Biomedical Instrumentation Lab is to develop novel instrumentation and technologies to study the brain at several levels--from single cell to the whole brain--with the goal of translating the work into practical research and clinical applications.

    Our personnel include diverse, independent-minded and entrepreneurial students, post docs, and research faculty who base their research on modern microfabrication, stem cell biology, electrophysiology, signal processing, image processing, and integrated circuit design technologies.

    Research Areas: stem cells, imaging, brain, electrophysiology, neuroengineering, biomedical engineering, neuroscience

    Lab Website

    Principal Investigator

    Nitish Thakor, Ph.D.

    Department

    Biomedical Engineering

  • Neuroimaging and Modulation Laboratory (NIMLAB)

    The neuroimaging and Modulation Laboratory (NIMLAB) investigates neural correlates of cognition and behavior using neuroimaging methods such as functional magnetic resonance imaging (fMRI) and neuromodulation techniques such as transcranial magnetic stimulation (TMS). We are looking in depth at the contributions of the cerebellum and cerebro-cerebellar circuits to cognition; the effects of chronic heavy alcohol consumption on cognition and brain activation underlying cognitive function; how aging in humans affects neural systems that are important for associative learning and stimulus awareness; and the integration of transcranial magnetic stimulation with functional MRI.

    Research Areas: cognition, alcohol, functional magnetic resonance imaging, imaging, aging, neuroscience, neuroimaging, transcranial magnetic stimulation

    Lab Website

    Principal Investigator

    John Desmond, M.S., Ph.D.

    Department

    Neurology

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