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  • Ashikaga Lab

    Lab Website

    We specialize in unconventional, multi-disciplinary approaches to studying the heart at the int...ersection of applied mathematics, physics and computer science. We focus on theory development that leads to new technology and value delivery to the society. Currently we have three research programs:

    1. Precision Medicine
    To develop a quantitative approach to personalized risk assessment for stroke and dementia based on patent-specific heart anatomy, function and blood flow.
    Disciplines: Cardiac Hemodynamics; Medical Imaging Physics; Continuum Mechanics; Computational Fluid Dynamics

    2. Information Theory
    To quantify and perturb cardiac fibrillation that emerges as a macro-scale behavior of the heart from micro-scale behaviors of inter-dependent components.
    Disciplines: Cardiac Electrophysiology; Spiral Wave; Information Theory; Complex Networks

    3. Artificial Intelligence
    To develop artificial intelligence algorithms to predict the future risk of heart attack, stroke and sudden death, and to assist surgical interventions to prevent these outcomes.
    Disciplines: Medical Imaging Physics; Artificial Intelligence; Robotically Assisted Interventions
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    Research Areas: complex systems, Computational Fluid Dynamics, spiral wave, artificial intelligence, informational theory
  • Braunstein Lab

    Lab Website
    Principal Investigator:
    Evan Braunstein, M.D., Ph.D.
    Medicine

    Dr. Braunstein's research focuses on inherited predisposition to hematologic diseases. His labo...ratory studies the inherited genetic changes in DNA that increase susceptibility to disease. Blood cancers such as myeloproliferative neoplasms and myelodysplastic syndromes are traditionally thought to be acquired disorders, however there is increasing evidence that inherited genetic changes play a role. In addition, Dr. Braunstein studies non-malignant blood diseases including atypical hemolytic uremic syndrome (aHUS) and related thrombotic disorders such as APLS, TTP and HELLP syndrome which are caused in part by genetic mutations. His work has identified a germline variants in the ERBB genes that predispose to hematologic malignancies. In addition, his research group found that patients with catastrophic APLS and HELLP syndrome frequently harbor germline mutations in complement regulatory genes. This has led directly to clinical trials designed to test the efficacy of complement inhibition in patients with these disorders. Dr. Braunstein continues to work toward translating the scientific findings from the laboratory into improved care and treatment for patients. view more

    Research Areas: Myeloproliferative neoplasms, complement disorders
  • Charles W. Flexner Laboratory

    Principal Investigator:
    Charles Flexner, M.D.
    Medicine

    A. Laboratory activities include the use of accelerator mass spectrometry (AMS) techniques to m...easure intracellular drugs and drugs metabolites. AMS is a highly sensitive method for detecting tracer amounts of radio-labeled molecules in cells, tissues, and body fluids. We have been able to measure intracellular zidovudine triphosphate (the active anabolite of zidovudine) in peripheral blood mononuclear cells from healthy volunteers given small doses of 14C-zidovudine, and have directly compared the sensitivity of AMS to traditional LC/MS methods carried out in our laboratory.

    B. Clinical research activities investigate the clinical pharmacology of new anti-HIV therapies and drug combinations. Specific drug classes studied include HIV reverse transcriptase inhibitors, protease inhibitors, entry inhibitors (selective CCR5 and CXCR4 antagonists), and integrase inhibitors. Scientific objectives of clinical studies include characterization of early drug activity, toxicity, and pharmacokinetics. Additional objectives are characterization of pathways of drug metabolism, and identification of clinically significant harmful and beneficial drug interactions mediated by hepatic and intestinal cytochrome P450 isoforms.
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    Research Areas: antiretroviral drugs, infectious disease, HIV protease inhibitors, HIV, drugs, accelerator mass spectrometry
  • Edgar Miller Lab

    Principal Investigator:
    Edgar Miller, M.D., Ph.D.
    Medicine

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current... projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease. view more

    Research Areas: nutrition, kidney diseases, diabetes, inflammation
  • Gail Daumit Lab

    Principal Investigator:
    Gail Daumit, M.D., M.H.S.
    Medicine

    Research in the Gail Daumit Lab is devoted to improving overall health and decreasing premature... mortality for people with serious mental illnesses, such as schizophrenia and bipolar disorder. We have conducted observational studies to determine and convey the burden of physical health problems in this vulnerable population, and are currently leading a randomized trial funded by the National Heart, Lung, and Blood Institute to test a comprehensive cardiovascular risk reduction program in people with serious mental illness. view more

    Research Areas: mental health, schizophrenia, bipolar disorder, cardiovascular diseases
  • Haughey Lab: Neurodegenerative and Neuroinfectious Disease

    Lab Website
    Principal Investigator:
    Norman Haughey, Ph.D.
    Neurology
    Neurosurgery

    Dr. Haughey directs a disease-oriented research program that address questions in basic neurobi...ology, and clinical neurology. The primary research interests of the laboratory are:

    1. To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
    2. To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitability.
    3. To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
    4. To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
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    Research Areas: multiple sclerosis, PTSD, HAND, HIV
  • Hsin-Chieh Yeh Lab

    Lab Website
    Principal Investigator:
    Hsin-Chieh Yeh, Ph.D.
    Medicine

    Work in the Hsin-Chieh Yeh Lab focuses on clinical trials and cohort studies of diabetes, obesi...ty and behavioral intervention, cancer and hypertension. Recent investigations have focused on novel risk factors and complications related to obesity and type 2 diabetes, particularly lung function, smoking and cancer. We recently co-led a randomized clinical trial of tailored dietary advice for consumption of dietary supplements to lower blood pressure and improve cardiovascular disease risk factors in hypertensive urban African Americans. view more

    Research Areas: epidemiology, African Americans, cancer, obesity, hypertension, diabetes, behavioral medicine
  • James Pekar Lab

    Lab Website

    How do we see, hear, and think? More specifically, how can we study living people to understand... how the brain sees, hears, and thinks? Recently, magnetic resonance imaging (MRI), a powerful anatomical imaging technique widely used for clinical diagnosis, was further developed into a tool for probing brain function. By sensitizing magnetic resonance images to the changes in blood oxygenation that occur when regions of the brain are highly active, we can make "movies" that reveal the brain at work. Dr. Pekar works on the development and application of this MRI technology.

    Dr. Pekar is a biophysicist who uses a variety of magnetic resonance techniques to study brain physiology and function. Dr. Pekar serves as Manager of the F.M. Kirby Research Center for Functional Brain Imaging, a research resource where imaging scientists and neuroscientists collaborate to study brain function using unique state-of-the-art techniques in a safe comfortable environment, to further develop such techniques, and to provide training and education. Dr. Pekar works with center staff to serve the center's users and to keep the center on the leading edge of technology.
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    Research Areas: magnetic resonance, functional magnetic resonance imaging, radiology
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