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The Urban Lab studies rhomboid proteases--a class of enzymes that cut proteins to initiate signaling between cells as a form of communication that organizes embryo development. Current studies in the lab focus on the biophysics of how these enzymes function inside the cell membrane, where it's hard for catalysis to take place. Because rhomboid intramembrane proteolysis plays a central role in malaria infection and Parkinson's disease pathogenesis, these studies may have therapeutic implications.
The Wolberger Lab is interested in the structural and mechanistic basis for transcriptional regulation and ubiquitin signaling as it relates to the integrity and expression of the genome. We use x-ray crystallography, enzymology, cell-based assays and a variety of biophysical tools to gain insights into the mechanisms underlying these essential cellular processes.
The objective of the Xiao Group's research is to study the dynamics of cellular processes as they occur in real time at the single-molecule and single-cell level. The depth and breadth of our research requires an interdisciplinary approach, combining biological, biochemical and biophysical methods to address compelling biological problems quantitatively. We currently are focused on dynamics of the E. coli cell division complex assembly and the molecular mechanism in gene regulation.
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