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Research Lab Results for biomarkers

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  • Pediatric Proteome Center

    Principal Investigator:
    Allen Everett, M.D.
    Medicine
    Pediatrics

    Allen Everett, M.D., and his colleagues are identifying new biomarkers — measurable, physical s...igns — to help in identifying pediatric heart disease. Everett is the program leader at Johns Hopkins in pediatric biomarker discovery, initially in sickle cell disease and subsequently in other pediatric clinical conditions (birth injury, congenital heart disease repair, ECMO, prematurity and pulmonary hypertension). view more

    Research Areas: pediatric biomarker discovery, heart disease, pediatric cardiology
  • Qian-Li Xue Lab

    Principal Investigator:
    Qian-Li Xue, Ph.D.
    Medicine

    The primary area of statistical expertise in the Qian-Li Xue Lab is the development and applica...tion of statistical methods for: (1) handling the truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (2) missing data, including outcome (e.g., frailty) censoring by a competing risk (e.g., mortality) and (3) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models. In Women's Health and Aging Studies, we have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time. view more

    Research Areas: epidemiology, disabilities, longitudinal data, hormonal dysregulation, women's health, inflammation, frailty, biostatistics, gerontology, latent variables
  • Richard F. Ambinder Lab

    Lab Website

    Epstein-Barr virus and Kaposi's sarcoma herpesvirus are found in association with a variety of ...cancers. Our laboratory studies are aimed at better defining the role(s) of the virus in the pathogenesis of these diseases and the development of strategies to prevent, diagnose or treat them. We have become particularly interested in the unfolded protein response in activation of latent viral infection. Among the notions that we are exploring is the possibility that activation of virus-encoded enzymes will allow the targeted delivery of radation. In addition, we are investigating a variety of virus-related biomarkers including viral DNA, antibody responses, and cytokine measurements that may be clinically relevant. view more

    Research Areas: virology, antiviral therapy
  • Srinivasan Yegnasubramanian Lab

    Lab Website

    Dr. Yegnasubramanian directs a Laboratory of Cancer Molecular Genetics and Epigenetics at the S...idney Kimmel Comprehensive Cancer Center (SKCCC), and is also the Director of the SKCCC Next Generation Sequencing Center.


    Our lab research is focused on understanding the complex interplay between genetic and epigenetic alterations in carcinogenesis and disease progression, and to exploit this understanding in developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention.
    view more

    Research Areas: cancer therapies, biomarkers, genetics, cancer, epigenetics
  • Steven Menez Lab

    Principal Investigator:
    Steven Menez, M.D., M.H.S.
    Medicine

    Dr. Menez and his laboratory are interested in clinical and translational acute kidney injury (...AKI) research, specifically with a focus on the transition between AKI and chronic kidney disease (CKD). Dr. Menez has investigated novel approaches to evaluate AKI using biomarkers of kidney injury, inflammation, and repair in the multi-center TRIBE-AKI and ASSESS-AKI Studies. Dr. Menez collaborates nationwide through the NIDDK-sponsored Kidney Precision Medicine Project, with a goal to improve the global understanding of kidney disease subgroups and identify new pathways and targets for novel therapies.



    Since the start of the COVID-19 pandemic, he has additionally investigated the impact of COVID19 on kidney health, including short-term outcomes including need for dialysis or in-hospital mortality, as well as longer-term outcomes post-hospital discharge.
    view more

    Research Areas: acute kidney injury, chronic kidney disease
  • Suzanne Topalian Lab

    Principal Investigator:
    Suzanne Topalian, M.D.
    Oncology

    Our lab currently focuses on three areas of immunotherapy research: gaining a deeper knowledge ...of the biological underpinnings of human autoimmune response; discovering biomarkers that will help us identify which patients and tumor types are most likely to respond to various immune therapies; and developing immune-based treatment combinations that could deliver a more powerful anti-tumor response than monotherapies. view more

    Research Areas: cancer, PD-1, melanoma, immunotherapy, cancer immunology
  • The Bettegowda Lab

    Lab Website

    Led by Dr. Chetan Bettegowda, our lab uses genetic analysis, biomarkers and patient outcome dat...a to identify better ways to diagnose and treat disease. We research a variety of neurological conditions, including central nervous system tumors, trigeminal neuralgia and traumatic brain and spinal injuries. view more

    Research Areas: trigeminal neuralgia, traumatic brain injury, brain tumor
  • The Bigos Lab

    The Bigos Lab focuses on a Precision Medicine approach to the treatment of psychiatric illness.... In addition, this lab employs functional neuroimaging and genetics as biomarkers in neuropsychiatric drug development. A recent study used functional MRI to test the neural effects of a drug with the potential to treat cognitive dysfunction in schizophrenia. Other studies aim to identify patient-specific variables including sex, race, and genetics that impact drug clearance and clinical response to better select and dose antipsychotics and antidepressants. view more

    Research Areas: cognition, brain disorders, schizophrenia, mental illness, fMRI, pharmacogenomics, neuroimaging
  • Translational Neurobiology Laboratory

    Lab Website

    The goals of the Translational neurobiology Laboratory are to understand the pathogenesis and c...ell death pathways in neurodegenerative disorders to reveal potential therapeutic targets for pharmaceutical intervention; to investigate endogenous survival pathways and try to induce these pathways to restore full function or replace lost neurons; and to identify biomarkers to mark disease function or replace lost neurons; and to identify biomarkers to mark disease progression and evaluate therapeutics. Our research projects focus on models of Huntington's disease and Parkinson's disease. We use a combination of cell biology and transgenic animal models of these diseases. view more

    Research Areas: Huntington's disease, neurodegenerative disorders, neurobiology, cell biology, Parkinson's disease
  • Zhu Lab

    The Zhu lab is focused on characterizing the activities of large collection of proteins, buildi...ng signaling networks for better understanding the mechanisms of biological processes, and identifying biomarkers in human diseases and cancers.

    More specifically, our group is interested in analyzing protein posttranslational modifications, and identifying important components involved in transcription networks and host-pathogen interactions on the proteomics level, and biomarkers in human IBD diseases.
    view more

    Research Areas: proteomics, biomarkers, cancer, genomics, protein chip, signaling networks
  • Zsuzsanna McMahan Lab

    Lab Website
    Principal Investigator:
    Zsuzsanna McMahan, M.D., M.H.S.
    Medicine

    The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel anti...gens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented. view more

    Research Areas: gastrointestinal system, rheumatology, biomarkers, scleroderma, antigens, mycophenolate mofetil
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