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• GI Biomarkers Laboratory

  The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.

  Research Areas: gastrointestinal system, biomarkers, cancer, epigenetics, genomics, bioinformatics, biogenesis

  Lab Website

  

  Principal Investigator

  Stephen Meltzer, M.D.

  Department

  Medicine
  

• Ryuya Fukunaga Lab

  The Fukunaga Lab uses multidisciplinary approaches to understand the cell biology, biogenesis and function of small silencing RNAs from the atomic to the organismal level.
  
  The lab studies how small silencing RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs), are produced and how they function. Mutations in the small RNA genes or in the genes involved in the RNA pathways cause many diseases, including cancers. We use a combination of biochemistry, biophysics, fly genetics, cell culture, X-ray crystallography and next-generation sequencing to answer fundamental biological questions and also potentially lead to therapeutic applications to human diseases.

  Research Areas: biophysics, biochemistry, cell biology, cell culture, genomics, RNA

  

  Principal Investigator

  Ryuya Fukunaga, Ph.D.

  Department

  Biological Chemistry
  

• Stephen Gould Laboratory

  The Gould Laboratory studies vesicles, known as exosomes and microvesicles (EMVs), that can be taken up by neighboring cells, completing a pathway of intercellular vesicle traffic.
  
  Our laboratory studies the molecular mechanisms of EMV biogenesis and uptake, and their contributions to cell polarity, cell-to-cell interactions, and intercellular signaling. We also examine the ways in which HIV and other retroviruses use the exosome biogenesis pathway for the formation of infectious virions, and the consequences of their EMV origin.

  Research Areas: biochemistry, EMV, HIV, vesicles, retroviruses

  

  Principal Investigator

  Stephen Gould, Ph.D.

  Department

  Biological Chemistry
  

• Venu Raman Research Lab

  The Raman laboratory is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The focus of the laboratory is bench-to-bed side cancer research. We integrate molecular and cellular biology, developmental biology, cancer biology, molecular imaging techniques to study cancer formation and progression. Many of the projects in the lab investigate dysregulated genes in cancer and the translatability of this information to a clinical setting. One such project is to functionally decipher the role of a RNA helicase gene, DDX3, in the biogenesis of multiple cancer types such as breast, lung, brain, sarcoma, colorectal and prostate. Additionally, using a rational drug design approach, a small molecule inhibitor of DDX3 (RK-33) was synthesized and its potential for clinical translation is being investigated.

  Research Areas: breast cancer, cancer, in vitro findings, molecule inhibitors

  

  Principal Investigator

  Venu Raman, Ph.D.

  Department

  Radiology and Radiological Science
  

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