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Displaying 1 to 10 of 43 results for biochemistry

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  • Aniket Sidhaye Lab

    Investigators in the Aniket Sidhaye Lab focus on the mechanism of nuclear hormone receptor action—with an emphasis on thyroid hormone receptors and PPAR-gamma obesity—and transitional care of patients with type 1 diabetes.

    Research Areas: biochemistry, obesity, hormones, diabetes, transitional care, endocrinology, thyroid

    Lab Website

    Principal Investigator

    Aniket Sidhaye, M.D.

    Department

    Medicine

  • Berger Lab

    The Berger Lab's research is focused on understanding how multi-subunit assemblies use ATP for overcoming topological challenges within the chromosome and controlling the flow of genetic information. A long-term goal is to develop mechanistic models that explain in atomic level detail how macromolecular machines transduce chemical energy into force and motion, and to determine how cells exploit and control these complexes and their activities for initiating DNA replication, shaping chromosome superstructure and executing myriad other essential nucleic-acid transactions.

    Our principal approaches include a blend of structural (X-ray crystallography, single-particle EM, SAXS) and solution biochemical methods to define the architecture, function, evolution and regulation of biological complexes. We also have extensive interests in mechanistic enzymology and the study of small-molecule inhibitors of therapeutic potential, the development of chemical approaches to trapping weak protein/p...rotein and protein/nucleic acid interactions, and in using microfluidics and single-molecule approaches for biochemical investigations of protein dynamics. view more

    Research Areas: biochemistry, proteomics, ATP, DNA, genomics

  • Bradley Undem Lab

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous system is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies.

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system

    Principal Investigator

    Bradley Undem, Ph.D.

    Department

    Medicine

  • Caren L. Freel Meyers Laboratory

    The long-term goal of the Caren L. Freel Meyers Laboratory is to develop novel approaches to kill human pathogens, including bacterial pathogens and malaria parasites, with the ultimate objective of developing potential therapeutic agents.

    Toward this goal, we are pursuing studies of bacterial isoprenoid biosynthetic enzymes comprising the methylerythritol phosphate (MEP) pathway essential in many human pathogens. Studies focus on understanding mechanism and regulation in the pathway toward the development of selective inhibitors of isoprenoid biosynthesis. Our strategies for creating new anti-infective agents involve interdisciplinary research in the continuum of organic, biological and medicinal chemistry. Molecular biology, protein expression and biochemistry, and synthetic chemistry are key tools for our research.

    Research Areas: bacterial pathogens, biochemistry, enzymes, infectious disease, protein expression, synthetic chemistry, isoprenoid biosynthesis, malaria, pharmacology, chemistry, molecular biology

  • Clifton O. Bingham III Lab

    Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis.

    Research Areas: biochemistry, imaging, osteoarthritis, clinical trials, inflammation, oral health, rheumatoid arthritis

    Principal Investigator

    Clifton O. Bingham, M.D.

    Department

    Medicine

  • Daniel Raben Laboratory

    The Raben Laboratory is focused on understanding the biochemistry and chemistry underlying the molecular aspects involved in regulating lipid metabolizing signaling enzymes and the physiological roles of this regulation. Controlling lipid-metabolizing enzymes involves modulating their sub-cellular distribution and their intrinsic enzymatic activity. Researchers in the Raben laboratory examine three families of lipid-metabolizing signaling enzymes: diacylglycerol kinases, phospholipases D, and phospholipases C.

    Research Areas: biochemistry, lipid-metabolizing enzymes, cellular signaling, chemistry

    Principal Investigator

    Daniel Raben, Ph.D.

    Department

    Biological Chemistry

  • David Shortle Lab

    The principal research interest of the Shortle Lab is protein folding--how amino acid sequence information encodes three-dimensional structure. We are taking a combined experimental and computational approach to this longstanding puzzle of fundamental biochemistry. In addition, the laboratory is working to predict protein structure from sequence in ways that make the underlying physical chemistry transparent and the relative contributions of different interactions quantifiable.

    Research Areas: biochemistry, computational biology, protein folding, protein structure

  • Devreotes Laboratory

    The Devreotes Laboratory is engaged in genetic analysis of chemotaxis in eukaryotic cells. Our long-term goal is a complete description of the network controlling chemotactic behavior. We are analyzing combinations of deficiencies to understand interactions among network components and carrying out additional genetic screens to identify new pathways involved in chemotaxis. A comprehensive understanding of this fascinating process should lead to control of pathological conditions such as inflammation and cancer metastasis.

    Research Areas: biochemistry, cell biology, chemotaxis, cancer, genomics, inflammation

    Lab Website

    Principal Investigator

    Peter Devreotes, Ph.D.

    Department

    Cell Biology

  • Foster Lab

    The Foster Lab uses the tools of protein biochemistry and proteomics to tackle fundamental problems in the fields of cardiac preconditioning and heart failure. Protein networks are perturbed in heart disease in a manner that correlates only weakly with changes in mRNA transcripts. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism. Understanding the status of protein networks in the diseased state is, therefore, key to discovering new therapies.

    D. Brian Foster, Ph.D., is an assistant professor of medicine in the division of cardiology, and serves as Director of the Laboratory of Cardiovascular Biochemistry at the Johns Hopkins University School of Medicine.


    Research Areas: proteomics, protein biochemistry, heart failure, cardiology, cardiac preconditioning, cardiomyopathy

    Lab Website

    Principal Investigator

    D. Brian Foster, M.Sc., Ph.D.

    Department

    Medicine

  • Frank Bosmans Lab

    Research in the Bosmans Lab seeks to address fundamental questions regarding the identities of the components of the voltage-activated sodium (Nav) channel signaling complex and to resolve their mechanisms of action at the molecular level. Our research combines several techniques including molecular biology, electrophysiology, genetics and biochemistry. Successful completion of these goals will reveal key elements in the Nav channel signaling complex, help define Nav channel function in normal and pathological states, and may offer novel strategies for developing therapeutic drugs.

    Research Areas: biochemistry, electrical signaling, electrophysiology, sodium channels, Nav channels, genomics, drugs, molecular biology

    Principal Investigator

    Frank Bosmans, M.S., Pharm.D.

    Department

    Physiology

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