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Research Lab Results for biochemistry

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  • Caren L. Freel Meyers Laboratory

    Lab Website

    The long-term goal of the Caren L. Freel Meyers Laboratory is to develop novel approaches to ki...ll human pathogens, including bacterial pathogens and malaria parasites, with the ultimate objective of developing potential therapeutic agents.

    Toward this goal, we are pursuing studies of bacterial isoprenoid biosynthetic enzymes comprising the methylerythritol phosphate (MEP) pathway essential in many human pathogens. Studies focus on understanding mechanism and regulation in the pathway toward the development of selective inhibitors of isoprenoid biosynthesis. Our strategies for creating new anti-infective agents involve interdisciplinary research in the continuum of organic, biological and medicinal chemistry. Molecular biology, protein expression and biochemistry, and synthetic chemistry are key tools for our research.
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    Research Areas: bacterial pathogens, biochemistry, enzymes, infectious disease, protein expression, synthetic chemistry, isoprenoid biosynthesis, malaria, pharmacology, chemistry, molecular biology
  • Daniel Raben Laboratory

    Principal Investigator:
    Daniel Raben, Ph.D.
    Biological Chemistry

    The Raben Laboratory is focused on understanding the biochemistry and chemistry underlying the ...molecular aspects involved in regulating lipid metabolizing signaling enzymes and the physiological roles of this regulation. Controlling lipid-metabolizing enzymes involves modulating their sub-cellular distribution and their intrinsic enzymatic activity. Researchers in the Raben laboratory examine three families of lipid-metabolizing signaling enzymes: diacylglycerol kinases, phospholipases D, and phospholipases C. view more

    Research Areas: biochemistry, lipid-metabolizing enzymes, cellular signaling, chemistry
  • Foster Lab

    Lab Website
    Principal Investigator:
    D. Brian Foster, Ph.D., M.Sc.
    Medicine

    The Foster Lab uses the tools of protein biochemistry and proteomics to tackle fundamental prob...lems in the fields of cardiac preconditioning and heart failure. Protein networks are perturbed in heart disease in a manner that correlates only weakly with changes in mRNA transcripts. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to contraction and metabolism. Understanding the status of protein networks in the diseased state is, therefore, key to discovering new therapies.

    D. Brian Foster, Ph.D., is an assistant professor of medicine in the division of cardiology, and serves as Director of the Laboratory of Cardiovascular Biochemistry at the Johns Hopkins University School of Medicine.


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    Research Areas: proteomics, protein biochemistry, heart failure, cardiology, cardiac preconditioning, cardiomyopathy
  • Green Lab

    Lab Website

    Work in the Green Lab is centered on the ribosome. The overall fidelity of protein synthesis ap...pears to be limited by the action of the ribosome, which is the two-subunit macromolecular machine responsible for decoding and translating messenger RNAs (mRNAs) into protein in all organisms. Our work is divided into four general project areas. The longest-standing research area concerns the interactions of eubacterial ribosomes and release factors. The goal is to understand the mechanism of action of release factors on the ribosome. A second research area involves biochemical and structure/function studies of the miRNA pathway, particularly the mechanism of action of the Argonaute proteins and their interacting factors. A third area of work in the lab is centered around regulation of eukaryotic translation, specifically in understanding the mechanism behind various mRNA quality control pathways and the interactions of proteins therein, as well as with the ribosome. The newest area of research in the lab extends our strengths in ribosome biochemistry to characterize the translation status of the cell using the ribosome profiling. We are using this technique to better understand the role of several factors involved in eukaryotic and prokaryotic translation fidelity. view more

    Research Areas: biochemistry, genomics, ribosome, RNA
  • Greider Lab

    Lab Website

    The Greider lab uses biochemistry to study telomerase and cellular and organismal consequences ...of telomere dysfunction. Telomeres protect chromosome ends from being recognized as DNA damage and chromosomal rearrangements. Conventional replication leads to telomere shortening, but telomere length is maintained by the enzyme telomerase. Telomerase is required for cells that undergo many rounds of divisions, especially tumor cells and some stem cells. The lab has generated telomerase null mice that are viable and show progressive telomere shortening for up to six generations. In the later generations, when telomeres are short, cells die via apoptosis or senescence. Crosses of these telomerase null mice to other tumor prone mice show that tumor formation can be greatly reduced by short telomeres. The lab also is using the telomerase null mice to explore the essential role of telomerase stem cell viability. Telomerase mutations cause autosomal dominant dyskeratosis congenita. People with this disease die of bone marrow failure, likely due to stem cell loss. The lab has developed a mouse model to study this disease. Future work in the lab will focus on identifying genes that induce DNA damage in response to short telomeres, identifying how telomeres are processed and how telomere elongation is regulated. view more

    Research Areas: telomerase, biochemistry, stem cells, cell biology, DNA
  • Holland Lab

    Lab Website

    Research in the Holland Lab focuses on the molecular mechanisms that control accurate chromosom...e distribution and the role that mitotic errors play in human health and disease. We use a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology. One of our major goals is to develop cell and animal-based models to study the role of cell-division defects in genome instability and tumorigenesis. view more

    Research Areas: cancer, genomics, molecular biology
  • Krishnan Lab

    Principal Investigator:
    Mohan Krishnan, Ph.D., M.S.
    Pediatrics

    Dr. Krishnan, Assistant Professor, received his Ph.D. in Biochemistry-Biotechnology from the Un...iversity of Madras in 2008. He completed his postdoctoral fellowship in the Department of Pediatrics at the University of Alabama at Birmingham and Department of Pediatrics, University of Illinois at Chicago. After he worked as Research Associate in Department of Pediatrics at the University of South Florida, Dr. Krishnan joined the faculty at JHU in May 2018. His lab investigates the pathophysiology of Transfusion-associated Necrotizing Enterocolitis (TANEC) and Systemic Inflammatory Response Syndrome (SIRS) in premature infants who are at high risk of anemia and heavily transfused. Dr. Krishnan is dedicated to understanding the role of monocyte/macrophage in the neonate and investigating their inflammatory phenotype, function during anemia and/or RBC-transfusion associated NEC and SIRS. view more

    Research Areas: Systemic Inflammatory Response Syndrome (SIRS), Transfusion-associated Necrotizing Enterocolitis (TANEC), pediatrics
  • Michael Caterina Lab

    The Caterina lab is focused on dissecting mechanisms underlying acute and chronic pain sensatio...n. We use a wide range of approaches, including mouse genetics, imaging, electrophysiology, behavior, cell culture, biochemistry and neuroanatomy to tease apart the molecular and cellular contributors to pathological pain sensation. A few of the current projects in the lab focus on defining the roles of specific subpopulations of neuronal and non-neuronal cells to pain sensation, defining the role of RNA binding proteins in the development and maintenance of neuropathic pain, and understanding how rare skin diseases known as palmoplantar keratodermas lead to severe pain in the hands and feet. view more

    Research Areas: biophysics, biochemistry, proteomics, inflammation, pain
  • Michael Wolfgang Laboratory

    The Wolfgang Laboratory is interested in understanding the metabolic properties of neurons and ...glia at a mechanistic level in situ. Some of the most interesting, enigmatic and understudied cells in metabolic biochemistry are those of the nervous system. Defects in these pathways can lead to devastating neurological disease. Conversely, altering the metabolic properties of the nervous system can have surprisingly beneficial effects on the progression of some diseases. However, the mechanisms of these interactions are largely unknown.

    We use biochemical and molecular genetic techniques to study the molecular mechanisms that the nervous system uses to sense and respond to metabolic cues. We seek to understand the neurometabolic regulation of behavior and physiology in obesity, diabetes and neurological disease.

    Current areas of study include deconstructing neurometabolic pathways to understand the biochemistry of the nervous system and how these metabolic pathways impact animal behavior and physiology, metabolic heterogeneity and the evolution of metabolic adaptation.
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    Research Areas: metabolic biochemistry, obesity, diabetes, genomics, neurology, nervous system, molecular biology
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