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Research Lab Results for basophils

Displaying 1 to 3 of 3 results
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  • David MacGlashan Laboratory

    Principal Investigator:
    Donald MacGlashan, M.D., Ph.D.
    Medicine

    Research in the Donald MacGlashan Laboratory aims to understand the regulation of secretion fro...m human basophils and mast cells—two cells thought to play key roles in allergic reactions and other diseases. The hallmark reaction in these cells is degranulation through cell-bound IgE. Our interests lie in the signaling mechanisms that control this dramatic cell response and the factors that regulate the degree of the reaction. view more

    Research Areas: mast cells, allergies, basophils
  • John Schroeder Lab

    Principal Investigator:
    John Schroeder, Ph.D.
    Medicine

    The John Schroeder Lab focuses on understanding the role human basophils and mast cells play in... allergic reactions, as it relates not only to their secretion of potent inflammatory mediators (e.g., histamine and leukotriene C4) but also to their production of pro-inflammatory cytokines. We have long utilized human cells rather than cell lines in order to address the parameters, signal transduction and pharmacological aspects underlying clinically relevant basophil and mast cell responses. As a result, the lab has established protocols for rapidly isolating large numbers of basophils at high purity from human blood and for growing culture-derived mast cells/basophils from human progenitor cells. A variety of assays and techniques are also in place for concurrently detecting cytokines and mediators following a wide range of stimuli. These have facilitated the in vitro testing of numerous anti-allergic drugs for inhibitory activity on basophil and mast cell activation. The lab also studies counter-regulation between the IgE and innate immune receptors on human immature dendritic cell subtypes. view more

    Research Areas: cell biology, allergies, inflammation
  • Sarbjit Saini Lab

    Principal Investigator:
    Sarbjit Saini, M.D.
    Medicine

    The research in the Sarbjit Saini Laboratory focuses on IgE receptor biology and IgE receptor-m...ediated activation of blood basophils and mast cells. We have examined the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis and chronic urticaria. Our research has been supported by the NIH, American Lung Association and the AAAAI. Our current research interests have focused mechanisms of diease in allergic asthma, allergic rhinitis and also translational studies in chronic idiopathic urticaria. view more

    Research Areas: anaphylaxis, airway diseases, cell biology, asthma, allergies, chronic idiopathic urticaria
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