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The Agrawal Lab is focused on the medical and surgical treatment of otologic and neurotologic conditions. Research is focused on the vestibular system (the inner ear balance system), and how the function of the vestibular system changes with aging. Particular focus is given to study how age-related changes in vestibular function influence mobility disability and fall risk in older individuals.
John Carey’s Research Group conducts research regarding diseases of the inner ear that affect both balance and hearing mechanisms. Key interests include superior semicircular canal dehiscence syndrome (SCDS), the normal vestibular reflexes and how they change with age, novel intratympanic treatments (i.e., middle ear injections) for conditions like Menière’s disease and sudden hearing loss, and the mechanisms of vestibular migraine. With Lloyd Minor, Dr. Carey helped develop the operation to repair the superior canal in patients with SCDS using image-guided surgery. Dr. Carey has been funded by the National Institutes of Health – National Institute on Deafness and Other Communication Disorders to study inner ear balance function in Menière’s disease and steroid treatment of sudden hearing loss.
Auditory hair cells, located in the inner ear cochlea, are critical for our ability to detect sound. Research in Dr. Doetzlhofer's laboratory focuses on ways to identify and characterize the molecular mechanisms of hair cell development in the mammalian auditory system. She is also seeking to identify the molecular roadblocks preventing mammalian hair cell regeneration.
The mission of the Elisseeff Lab is to engineer technologies to repair lost tissues. We aim to bridge academic research and technology discovery to treat patients and address clinically relevant challenges related to tissue engineering. To accomplish this goal we are developing and enabling materials, studying biomaterial structure-function relationships and investigating mechanisms of tissue development to practically rebuild tissues. The general approach of tissue engineering is to place cells on a biomaterial scaffold that is designed to provide the appropriate signals to promote tissue development and ultimately restore normal tissue function in vivo. Understanding mechanisms of cellular interactions (both cell-cell and cell-material) and tissue development on scaffolds is critical to advancement of the field, particularly in applications employing stem cells. Translation of technologies to tissue-specific sites and diseased environments is key to better design, understanding, and... ultimately efficacy of tissue repair strategies. We desire to translate clinically practical strategies, in the form of biomaterials/medical devices, to guide and enhance the body's natural capacity for repair. To accomplish the interdisciplinary challenge of regenerative medicine research, we maintain a synergistic balance of basic and applied/translational research. view less
The John Carey Lab studies inner ear balance function in Menière’s disease and steroid treatment of sudden hearing loss. Other research of interest includes the normal vestibular reflexes and how they change with age, the ototoxic effects of gentamicin, the use of intratympanic steroids for Menière’s disease, the diagnostic utility of vestibular evoked myogenic potential testing, and the mechanisms of vestibular migraine.
We are interested in understanding how innate immune responses regulate lung health. Innate immunity involves ancient, and well-conserved mediators and their actions regulate the balance between homeostasis and pathogenesis. In the lungs, innate immunity play a critical role in response to environmental exposures such as allergen and ambient particulate matter. My lab focuses on how these exposures can promote aberrant mucosal responses that can drive the development of diseases like asthma.
Principal Investigator
Department
Dr. Fridman's research group invents and develops bioelectronics for Neuroengineering and Medical Instrumentation applications. We develop innovative medical technology and we also conduct the necessary biological studies to understand how the technology could be effective and safe for people.
Our lab is currently focused on developing the "Safe Direct Current Stimulation" technology, or SDCS. Unlike the currently available commercial neural prosthetic devices, such as cochlear implants, pacemakers, or Parkinson's deep brain stimulators that can only excite neurons, SDCS can excite, inhibit, and even sensitize them to input. This new technology opens a door to a wide range of applications that we are currently exploring along with device development: e.g. peripheral nerve stimulation for suppressing neuropathic pain, vestibular nerve stimulation to correct balance disorders, vagal nerve stimulation to suppress an asthma attack, and a host of other neuroprosthetic applications.
M...edical Instrumentation MouthLab is a "tricorder" device that we invented here in the Machine Biointerface Lab. The device currently obtains all vital signs within 60s: Pulse rate, breathing rate, temperature, blood pressure, blood oxygen saturation, electrocardiogram, and FEV1 (lung function) measurement. Because the device is in the mouth, it has access to saliva and to breath and we are focused now on expanding its capability to obtaining measures of dehydration and biomarkers that could be indicative of a wide range of internal disorders ranging from stress to kidney failure and even lung cancer.
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Our team is focused on understanding how complex movements are normally learned and controlled, and how damage to specific brain areas impairs these processes. We employ several techniques to quantify movement including: 3-dimensional tracking and reconstruction of movement, recordings of muscle activity, force plate recordings, and calculation of joint forces and torques. These techniques allow for very precise measurements of many different types of movements including: walking, reaching, leg movements, hand movements and standing balance. All studies are designed to test specific hypotheses about the function of different brain areas, the cause of specific impairments and/or the effects of different interventions.
In our laboratory we study the brain mechanisms of eye movements and spatial orientation.
-How magnetic stimulation through transcranial devices affects cortical brain regions
-Neural mechanisms underlying balance, spatial orientation and eye movement
-Mathematical models that describe the function of ocular motor systems and perception of spatial orientation
-Short- and long-term adaptive processes underlying compensation for disease and functional recovery in patients with ocular motor, vestibular and perceptual dysfunction
Developing and testing novel diagnostic tools, treatments, and rehabilitative strategies for patients with ocular motor, vestibular and spatial dysfunction
The Sesaki Lab is interested in the molecular mechanisms and physiological roles of mitochondrial fusion. Mitochondria are highly dynamic and control their morphology by a balance of fusion and fission. The regulation of membrane fusion and fission generates a striking diversity of mitochondrial shapes, ranging from numerous small spheres in hepatocytes to long branched tubules in myotubes. In addition to shape and number, mitochondrial fusion is critical for normal organelle function.
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