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Displaying 11 to 20 of 22 results for autoimmune

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  • Jean Kim Lab

    The Jean Kim Laboratory performs translational research in the
    area of chronic rhinosinusitis, with a niche interest in the pathogenesis of hyperplastic nasal
    polyposis. Studies encompass clinical research to basic wet laboratory research in
    studying the underlying immune and autoimmune mediated mechanism of polyp growth and
    perpetuation of disease. Human cell and tissue culture models are used. Techniques in the
    laboratory include cell and tissue culture, real time PCR, immunoblot, ELISA, flow cytometry,
    immunohistochemistry, electron microscopy, gene array analysis, and other molecular
    approaches including genetic knockdowns. Approaches used in Dr. Kim’s clinical study
    designs include prospective and retrospective analysis of patient outcomes and clinical
    biomarkers, as wells controlled clinical trials.

    Research Areas: nasal polyps, chronic rhinosinusitis, hyperplastic nasal polyposis

  • Joel Pomerantz Laboratory

    The Pomerantz Laboratory studies the molecular machinery used by cells to interpret extracellular signals and transduce them to the nucleus to affect changes in gene expression. The accurate response to extracellular signals results in a cell's decision to proliferate, differentiate or die, and it's critical for normal development and physiology. The dysregulation of this machinery underlies the unwarranted expansion or destruction of cell numbers that occurs in human diseases like cancer, autoimmunity, hyperinflammatory states and neurodegenerative disease.

    Current studies in the lab focus on signaling pathways that are important in innate immunity, adaptive immunity and cancer, with particular focus on pathways that regulate the activity of the pleiotropic transcription factor NF-kB.

    Research Areas: immunology, neurodegenerative disorders, cancer, autoimmune, hyperinflammatory states, molecular biology

    Principal Investigator

    Joel Pomerantz, Ph.D.

    Department

    Biological Chemistry

  • Jun O. Liu Laboratory

    The Jun O. Liu Laboratory tests small molecules to see if they react in our bodies to find potential drugs to treat disease. We employ high-throughput screening to identify modulators of various cellular processes and pathways that have been implicated in human diseases from cancer to autoimmune diseases. Once biologically active inhibitors are identified, they will serve both as probes of the biological processes of interest and as leads for the development of new drugs for treating human diseases. Among the biological processes of interest are cancer cell growth and apoptosis, angiogenesis, calcium-dependent signaling pathways, eukaryotic transcription and translation.

    Research Areas: cancer, autoimmune, eukaryotic cells, drugs, cellular signaling, pharmacology, calcium-dependent signaling pathways, molecular biology, angiogenesis

  • Livia Casciola-Rosen Lab

    Work in the Livia Casciola-Rosen Lab explores the shared mechanisms present in autoimmune rheumatic diseases, specifically scleroderma, Sjogren's syndrome and myositis. We use disease-specific autoantibodies to identify the factors that cause the autoimmune response in such diseases. Our current research involves identifying the antigen targets of autoimmune diseases, investigating the autoantigens targeted in cancers associated with rheumatic diseases and finding unique clinical biomarkers, such as the anti-HMGCR antibody specificity.

    Research Areas: autoantibodies, myositis, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases

    Principal Investigator

    Livia Casciola-Rosen, Ph.D.

    Department

    Medicine

  • Maureen Horton Lab

    The Maureen Horton Lab conducts research on pulmonary fibrosis through the use of both preclinical models and human trials. Our studies have helped to develop novel, genetic, tissue-specific models of immune dysfunction, which have aided in defining the immune regulation of fibrosis and in the development of treatment strategies. We have used T-cell skewing immunotherapy to prevent and reverse chemical-induced lung fibrosis and have conducted clinical trials for idiopathic pulmonary fibrosis (IPF), which led to one of the first treatments that helped to improve quality of life in IPF patients.

    Research Areas: interstitial lung diseases, idiopathic pulmonary fibrosis, pulmonary fibrosis, autoimmune diseases, occupational lung diseases, T cells

    Principal Investigator

    Maureen Horton, M.D.

    Department

    Medicine

  • Philip Seo Lab

    Research interests in the Philip Seo Lab include the assessment and treatment of ANCA-associated vasculitides, particularly Churg-Strauss syndrome, granulomatosis with polyangiitis and microscopic polyangiitis.

    Research Areas: microscopic polyangiitis, granulomatosis with polyangiitis, Churg-Strauss syndrome, autoimmune diseases

    Principal Investigator

    Philip Seo, M.D.

    Department

    Medicine

  • Schneck Lab

    Effective immune responses are critical for control of a variety of infectious disease including bacterial, viral and protozoan infections as well as in protection from development of tumors. Central to the development of an effective immune response is the T lymphocyte which, as part of the adaptive immune system, is central in achieving sterilization and long lasting immunity. While the normal immune responses is tightly regulated there are also notable defects leading to pathologic diseases. Inactivity of tumor antigen-specific T cells, either by suppression or passive ignorance allows tumors to grow and eventually actively suppress the immune response. Conversely, hyperactivation of antigen-specific T cells to self antigens is the underlying basis for many autoimmune diseases including: multiple sclerosis; arthritis; and diabetes. Secondary to their central role in a wide variety of physiologic and pathophysiologic responses my lab takes a broad-based approach to studying T cell re...sponses. view more

    Research Areas: t-cell responses, pathologic diseases, autoimmune diseases, pathology, immune system

    Lab Website

    Principal Investigator

    Jonathan Schneck, M.D., Ph.D.

    Department

    Pathology

  • Soloski Lab

    The Soloski Lab works to understand how infection can lead to the development of chronic immune-mediated diseases. Our lab studies the role of cellular immune response in controlling infection with gram-negative bacterial pathogens, such as Salmonella typhimurium. Our work has recently focused on the role of the intestinal mucosal immune compartment in controlling oral infection. This effort has identified a new unrecognized subset of T cells residing within the epithelial barrier that expands following infection. Current efforts concentrate on understanding the recognition properties and effector function of this T cell subset and determining if an analogous population exists in the human mucosa. We also strive to understand the human host immune response to infection with Borrelia burgdorfer, the causative agent of Lyme disease.

    Research Areas: bacterial pathogens, immunology, rheumatology, infectious disease, Lyme disease, autoimmune diseases, Salmonella, T cells

    Lab Website

    Principal Investigator

    Mark Soloski, Ph.D.

    Department

    Medicine

  • Sonye Danoff Lab

    Research in the Sonye Danoff Lab includes both basic and translational studies of lung fibrosis. We have explored topics such as the role of support measures and palliative care, pulmonary manifestations of Sjogren's syndrome, idiopathic inflammatory myopathies and the treatment of cough in idiopathic pulmonary fibrosis. Our research has also involved investigating the lung as a potential target for the immune reaction in myositis.

    Research Areas: myositis, interstitial lung diseases, Sjogren's syndrome, lung disease, pulmonary fibrosis, autoimmune diseases

    Principal Investigator

    Sonye Danoff, M.D., Ph.D.

    Department

    Medicine

  • Suzanne Topalian Lab

    Our lab currently focuses on three areas of immunotherapy research: gaining a deeper knowledge of the biological underpinnings of human autoimmune response; discovering biomarkers that will help us identify which patients and tumor types are most likely to respond to various immune therapies; and developing immune-based treatment combinations that could deliver a more powerful anti-tumor response than monotherapies.

    Research Areas: cancer, PD-1, melanoma, immunotherapy, cancer immunology

    Principal Investigator

    Suzanne Topalian, M.D.

    Department

    Oncology

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