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Roger Johns Lab
Investigators in the Roger Johns Lab are examining the molecular mechanisms behind the onset and continuation of chronic pain, particularly neuropathic pain. This work has led to a better understanding of the vast network of molecules at neuronal synapses, particularly the postsynaptic density (PSD), which is key to the propagation of pain signals. We're working to develop new analgesics that interfere with the PSD protein interactions in an effort to better treat patients who suffer from chronic pain.
Sarbjit Saini Lab
The research in the Sarbjit Saini Laboratory focuses on IgE receptor biology and IgE receptor-mediated activation of blood basophils and mast cells. We have examined the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis and chronic urticaria. Our research has been supported by the NIH, American Lung Association and the AAAAI. Our current research interests have focused mechanisms of diease in allergic asthma, allergic rhinitis and also translational studies in chronic idiopathic urticaria.
Our research laboratory is staffed by a dedicated and experienced team of sleep scientists, fellows, technicians, engineers, and students. Currently, we are focused on the following areas:
-Novel treatments for sleep apnea using electrical and nerve stimulation and chemogenetic techniques
-Cardiovascular and metabolic effects of sleep apnea and hypoxia
-Leptin and its impact on breathing and cardiovascular physiology
-Sleep disordered breathing at high altitude
-Dietary impacts on asthma