Find a Research Lab

Enter a research interest, principal investigator or keyword

Displaying 1 to 8 of 8 results for antibiotics

Show: 10 · 20 · 50

  1. 1
  • Cullman Chemoprotection Center

    Research in the Cullman Chemoprotection Center focuses on developing nutritional strategies for chronic disease prevention in humans. Our work draws from natural product chemistry, enzymology, nutritional epidemiology and clinical research. A number of our studies look at the glucosinolates and isothiocyanates found in cruciferous vegetables and in Moringa oleifera, also known as the “drumstick tree.” Our team has found that broccoli sprouts are a rich source of the enzyme inducers that detoxify carcinogens and that two of the inducers — sulforaphane in broccoli and isothiocyanate in Moringa oleifera — act as strong antibiotics against Helicobacter pylori, which can cause peptic ulcer disease and stomach cancer.

    Research Areas: nutrition, chemoprotection, cancer, disease prevention, chemistry

  • David Sack Lab

    Research in the David Sack Lab focuses on enteric infections. Our team has worked to develop laboratory detection methods to better understand the epidemiology of these agents. We also work to create appropriate clinical management strategies, such as antibiotics and rehydration methods, for enteric infections. Our work has included participating in the development of vaccines for a range of bacterial infections, including rotavirus, cholera and enterotoxigenic E. coli.

    Research Areas: epidemiology, international health, cholera, infectious disease, diarrhea, malaria, tuberculosis

    Principal Investigator

    David Sack, M.D.

    Department

    Medicine

  • Dolores Njoku Lab

    Research in the Dolores Njoku Lab focuses on immune-mediated liver injury caused by drugs such as anti-seizure medications and antibiotics. We use an animal model to understand the pathways involved in the injury process, recognizing that this model can also uncover pathways involved with other drugs that cause similar liver injury. We hope to uncover the immunogenic epitopes, or pieces, of the proteins that trigger the autoimmune reaction and identify the key regulatory pathways involved.

    Research Areas: anesthesia, antibiotics, liver injury, liver diseases, mouse models

  • Eric Nuermberger Lab

    Research in the Eric Nuermberger Lab focuses primarily on experimental chemotherapy for tuberculosis. We use proven murine models of active and latent tuberculosis infection to assess the effectiveness of novel antimicrobials. A key goal is to identify new agents to combine with existing drugs to shorten tuberculosis therapy or enable less frequent drug administration. We're also using a flow-controlled in vitro pharmacodynamic system to better understand the pharmacodynamics of drug efficacy and the selection of drug-resistant mutants during exposure to current agents.

    Research Areas: pharmacodynamics, chemotherapy, infectious disease, antimicrobials, drugs, antibiotics, Streptococcus pneumoniae, pneumonia, tuberculosis

    Principal Investigator

    Eric Nuermberger, M.D.

    Department

    Medicine

  • Frueh Laboratory

    The Frueh Laboratory uses nuclear magnetic resonance (NMR) to study how protein dynamics can be modulated and how active enzymatic systems can be conformed. Non-ribosomal peptide synthetases (NRPS) are large enzymatic systems that biosynthesize secondary metabolites, many of which are used by pharmaceutical scientists to produce drugs such as antibiotics or anticancer agents. Dr. Frueh's laboratory uses NMR to study inter- and intra-domain modifications that occur during the catalytic steps of NRPS. Dr. Frueh and his team are constantly developing new NMR techniques to study these complicated enzymatic systems.

    Research Areas: enzymes, proteomics, imaging, drugs, antibiotics, nuclear magnetic resonance, molecular biology

  • Karakousis Lab

    The Karakousis Lab is primarily focused on understanding the molecular basis of Mycobacterium tuberculosis persistence and antibiotic tolerance. A systems biology-based approach, including the use of several novel in vitro and animal models, in combination with transcriptional, proteomic, genetic, imaging, and computational techniques, is being used to identify host cytokine networks responsible for immunological control of M. tuberculosis growth, as well as M. tuberculosis regulatory and metabolic pathways required for bacillary growth restriction and reactivation. In particular, we are actively investigating the regulatory cascade involved in the mycobacterial stringent response. Another major focus of the lab is the development of host-directed therapies for TB, with the goal of shortening treatment and improving long-term lung function. Additional research interests include the development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB diseas...e, and for the detection of drug resistance. view more

    Research Areas: diagnostics, persistence, infectious disease, Mycobacterium tuberculosis, host-directed therapy, latency, drugs, antibiotics, tuberculosis

    Lab Website

    Principal Investigator

    Petros Karakousis, M.D.

    Department

    Medicine

  • Sara Cosgrove Lab

    The Sara Cosgrove Lab researches how infections with antibiotic-resistant bacteria affect patients. We are interested in the methods needed to make sure patients receive the best possible antibiotic treatment, including the development of tools and programs to promote the rational use of antimicrobials. We also study the epidemiology and management of S. aureus bacteremia.

    Research Areas: epidemiology, antimicrobials, antibiotics, resistant organisms

    Principal Investigator

    Sara Cosgrove, M.D.

    Department

    Medicine

  • Todd Dorman Lab

    Research conducted in the Todd Dorman Lab examines the use of informatics in intensive care settings as it relates to remote patient monitoring, safety and management strategies. Specific areas of interest include the surgical stress response; aminoglycoside antibiotics; fungal infections; renal failure; pharmacokinetic models of drug administration; and ICU triage and its impact on disaster preparedness.

    Research Areas: fungal infections, patient safety, informatics, disaster preparedness, aminoglycoside antibiotics, surgical stress response, ICU, patient monitoring

  1. 1