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Research Lab Results for anemia

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  • David Sullivan Lab

    Research in the David Sullivan Lab focuses on malaria, including its diagnosis, treatment, mole...cular biology as it relates to iron, and pathology as it relates to severe anemia. We test and develop new malaria diagnostics — from real-time polymerase chain reaction (PCR) to novel urine and saliva detection platforms. This includes the adaptation of immuno-PCR (antibody coupled to DNA for PCR detection) to malaria and a lead blood stage drug that contains a quinine derivative used to treat malaria in the 1930s. view more

    Research Areas: molecular immunology, iron, anemia, malaria, molecular microbiology
  • Krishnan Lab

    Dr. Krishnan, Assistant Professor, received his Ph.D. in Biochemistry-Biotechnology from the Un...iversity of Madras in 2008. He completed his postdoctoral fellowship in the Department of Pediatrics at the University of Alabama at Birmingham and Department of Pediatrics, University of Illinois at Chicago. After he worked as Research Associate in Department of Pediatrics at the University of South Florida, Dr. Krishnan joined the faculty at JHU in May 2018. His lab investigates the pathophysiology of Transfusion-associated Necrotizing Enterocolitis (TANEC) and Systemic Inflammatory Response Syndrome (SIRS) in premature infants who are at high risk of anemia and heavily transfused. Dr. Krishnan is dedicated to understanding the role of monocyte/macrophage in the neonate and investigating their inflammatory phenotype, function during anemia and/or RBC-transfusion associated NEC and SIRS. view more

    Research Areas: Systemic Inflammatory Response Syndrome (SIRS), Transfusion-associated Necrotizing Enterocolitis (TANEC), pediatrics
  • Linda Smith-Resar Lab

    Lab Website

    The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanism...s that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention. view more

    Research Areas: blood disorders, sickle cell diseases, blood management programs, hematologic malignancies
  • Peter Agre Lab

    Principal Investigator:
    Peter Agre, M.D.
    Research Animal Resources

    Work in the Peter Agre Lab focuses on the molecular makeup of human diseases, particularly mala...ria, hemolytic anemias and blood group antigens. In 2003, Dr. Agre earned the Nobel Prize in Chemistry for discovering aquaporin water channels. Building on that discovery, our recent research has included studies on the protective role of the brain water channel AQP4 in murine cerebral malaria, as well as defective urinary-concentrating ability as a result of a complete deficiency in aquaporin-1. We also collaborate on scientific training and research efforts with 20 Baltimore-area labs and in field studies in Zambia and Zimbabwe. view more

    Research Areas: infectious disease, anemia, malaria
  • Robert Brodsky Lab

    Investigators in the Robert Brodsky Lab study normal and abnormal hematopoiesis, particularly m...utations of the phosphatidylinositol glycan anchor biosynthesis class A (PIG-A) gene in aplastic anemia. Our team has developed a new diagnostic assay for paroxysmal nocturnal hemoglobinuria (PNH) that is based on the toxin Aaeromonas hydrophila. view more

    Research Areas: high-dose cyclophosphamide, hematopoiesis, paroxysmal nocturnal hemoglobinuria, aplastic anemia
  • Steven Frank Lab

    Research in the Steven Frank Lab focuses on processes to improve blood use and to avoid blood t...ransfusions for patients who do not want to receive blood or blood products. Processes include autologous hemodilution and cell salvage, and treating or averting anemia pre- and post-surgery. Other lab studies have focused on blood conservation, bloodless medicine surgery, the regulation of body temperature during surgery and methods of preventing hypothermia during surgery. view more

    Research Areas: bloodless surgery, blood disorders, hypothermia, blood transfusions, blood conservation, cell salvage, anemia, autologous hemodilution, bloodless medicine
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