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• Neuromodulation and Advanced Therapies Center

  We investigate the brain networks and neurotransmitters involved in symptoms of movement disorders, such as Parkinson's disease, and the mechanisms by which modulating these networks through electrical stimulation affects these symptoms. We are particularly interested in the mechanisms through which neuromodulation therapies like deep brain stimulation affect non-motor brain functions, such as cognitive function and mood. We use imaging of specific neurotransmitters, such as acetylcholine and dopamine, to understand the changes in brain chemistry associated with the clinical effects of deep brain stimulation and to predict which patients are likely to have changes in non-motor symptoms following DBS. Through collaborations with our neurosurgery colleagues, we explore brain function by making recordings during DBS surgery during motor and non-motor tasks. Dr. Mills collaborates with researchers in the Department of Neurosurgery, the Division of Geriatric and Neuropsychiatry in the Depar...tment of Psychiatry and Behavioral Sciences and in the Division of Nuclear Medicine within the Department of Radiology to translate neuroimaging and neurophysiology findings into clinical applications. view more

  Research Areas: Molecular imaging of effects of deep brain stimulation on cognitive function in Parkinson's disease, Trajectories and types of cognitive impairment in Parkinson's disease, Effects of neuromodulation on impulsivity and addiction-related behaviors, Parkinson's disease, Effects of transcranial direct current stimulation on mood disorders and cognitive dysfunction in Parkinson's disease, Relationship between patient-reported and objective cognitive impairments in Parkinson's disease

  

  Principal Investigator

  Kelly Mills, M.D., M.H.S.

  Department

  Neurology
  Neurosurgery
  

• Robert Fitzgerald Laboratory

  The Robert Fitzgerald Laboratory studies cardiopulmonary physiology, especially cardiopulmonary control. We have focused in particular on the operation of the carotid body and the role of acetylcholine in its functioning. We have also examined the reflex effects of carotid body stimulation in various organs as well as the reflex response of ACTH and adrenal cortical hormones to hypoxic peripheral arterial chemoreceptor stimulation. We are currently interested in the spleen, as it is the only organ other than the lung that demonstrates increased vascular resistance in response to local hypoxia.

  Research Areas: acetylcholine, carotid body, cardiopulmonary diseases, lung disease, hypoxia

  

  Principal Investigator

  Robert Fitzgerald, Ph.D.

  Department

  Medicine
  

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