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Displaying 1 to 4 of 4 results for SIV

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  • David Graham Lab

    The David Graham Lab studies the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions. We apply advanced technologies like mass spectrometry to dissect processes at the molecular level. We are also actively involved in cardiovascular research and studies the ways proteins are organized into functional units in different cell types of the heart. Major projects in our lab are organized into three major areas: (1) H/SIV pathogenesis and neuropathogenesis, (2) Cardiovascular disease, and (3) High technology development

    Research Areas: immunology, mass spectrometry, HIV, cardiovascular, SIV, pathogenesis

    Lab Website

    Principal Investigator

    David Graham, M.S., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • JHU NIMH Research Center

    The Johns Hopkins NIMH Center is comprised of an interdisciplinary research team who has pooled their talents to study the nature of HIV-associated neurocognitive disorders (HAND). Their aim is to translate discoveries of the pathophysiological mechanisms into novel therapeutics for HAND.Our objectives are to integrate aspects of ongoing research in HAND and SIV encephalitis; to develop high-throughput and screening assays for identifying novel therapeutic compounds; to use proteomics and lipidomics approaches to indentifying surrogate markers of disease activity; to disseminate information and education about HAND through existing and new educational systems, including the JHU AIDS Education Training Center and the JHU Center for Global Clinical Education and to facilitate the entry of new investigators into neuro-AIDS research, and to catalyze new areas of research, particularly where relevant for drug discovery or the development of validated surrogate markers.

    Research Areas: neuropathy, HAND, AIDS dementia complex, myopathy, myelopathy, HIV-associated neurocognitive disorders

    Lab Website

    Principal Investigator

    Justin McArthur, M.B.B.S., M.P.H.

    Department

    Neurology

  • Joseph Mankowski Lab

    The Joseph Mankowski Lab studies the immunopathogenesis of HIV infection using the SIV/macaque model. Our researchers use a multidisciplinary approach to dissect the mechanism underlying HIV-induced nervous system and cardiac diseases. Additionally, we study the role that host genetics play in HIV-associated cognitive disorders.

    Research Areas: macaques, HIV, genomics, SIV, pathogenesis, cardiology, nervous system

    Principal Investigator

    Joseph L. Mankowski, D.V.M., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Retrovirus Laboratory

    Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections. In particular, we study the simian immunodeficiency virus (SIV) to determine the molecular basis for the development of HIV CNS, pulmonary and cardiac disease. Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. We are also interested in studies of lentivirus replication in macrophages and astrocytes and their role in the development of disease. These studies have led us to identify the viral genes that are important in neurovirulence of SIV and the development of CNS disease including NEF and the TM portion of ENV. The mechanisms of the action of these proteins in the CNS are complex and are under investigation. We have also developed a rapid, consistent SIV/macaque model in which we can test the ability of various antiviral and neuroprotective agents to reduce the severity of CNS and pu...lmonary disease. view more

    Research Areas: HIV, genomics, pulmonology, SIV, cardiology, lentivirus

    Lab Website

    Principal Investigator

    Janice Clements, Ph.D.

    Department

    Molecular and Comparative Pathobiology

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