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Research Lab Results for RAS

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  • Inoue Lab

    Lab Website
    Principal Investigator:
    Takanari Inoue, Ph.D.
    Cell Biology

    Complexity in signaling networks is often derived from co-opting one set of molecules for multi...ple operations. Understanding how cells achieve such sophisticated processing using a finite set of molecules within a confined space--what we call the "signaling paradox"--is critical to biology and engineering as well as the emerging field of synthetic biology.

    In the Inoue Lab, we have recently developed a series of chemical-molecular tools that allow for inducible, quick-onset and specific perturbation of various signaling molecules. Using this novel technique in conjunction with fluorescence imaging, microfabricated devices, quantitative analysis and computational modeling, we are dissecting intricate signaling networks.

    In particular, we investigate positive-feedback mechanisms underlying the initiation of neutrophil chemotaxis (known as symmetry breaking), as well as spatio-temporally compartmentalized signaling of Ras and membrane lipids such as phosphoinositides. In parallel, we also try to understand how cell morphology affects biochemical pathways inside cells. Ultimately, we will generate completely orthogonal machinery in cells to achieve existing, as well as novel, cellular functions. Our synthetic, multidisciplinary approach will elucidate the signaling paradox created by nature.
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    Research Areas: biochemistry, cell biology, chemotaxis, cancer, signaling paradox, signaling networks, molecular biology, synthetic biology
  • Peter Abadir Lab

    Principal Investigator:
    Peter Abadir, M.D.
    Medicine

    Research in the Peter Abadir Lab focuses on the renin-angiotensin system (RAS), a signaling pat...hway that regulates blood pressure and has been linked independently to both aging and inflammation. We’re particularly interested in changes in RAS that occur with aging. We also study signal transduction and the role of the crosstalk between angiotensin II receptor in aging and are interested in understanding the function of angiotensin II in the process of vascular aging. view more

    Research Areas: renin-angiotensin system, aging, inflammation, gerontology
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