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Research Lab Results for Hepatitis

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  • Andrea Cox Lab

    Principal Investigator:
    Andrea Cox, M.D., Ph.D.
    Medicine

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a... focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design. view more

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells
  • Balagopal Lab - Viral Hepatitis and Translational Virology

    Principal Investigator:
    Ashwin Balagopal, M.D.
    Medicine

    The Balagopal Lab has adapted high-resolution tools to study viruses in situ. Specifically, we ...were the first to quantify hepatitis C virus (HCV) infection in single hepatocytes by developing single-cell laser capture microdissection (scLCM) and integrating this tool with highly sensitive quantitative real-time PCR. We reported that HCV infects a minority of hepatocytes that are found in geospatial clusters. More recently, we (PIs Balagopal and Thio) integrated scLCM with droplet digital PCR (ddPCR) to reveal the first observations of hepatitis B virus (HBV) infection at single cell resolution in the liver. We found that HBV infects nearly all hepatocytes prior to antiviral therapy. However, during antiviral therapy, HBV infection is diminished while viral transcription is markedly attenuated.

    Our lab has also focused on HIV-1 infection and immune activation for over a decade. Most recently, we have studied type 1 interferon responses to HIV-1 using RNA sequencing (RNAseq). Using this technology, we identified novel interferon-stimulated genes (ISGs) that are associated with HIV-1 restriction in vivo.
    view more

    Research Areas: HIV-1, hepatitis B, hepatitis C
  • Christine Durand Lab

    Principal Investigator:
    Christine Durand, M.D.
    Medicine

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopk...ins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased donor liver transplantation.
    view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C
  • David Thomas Lab

    Principal Investigator:
    David Thomas, M.D., M.P.H.
    Medicine

    The David Thomas Lab oversees clinical research projects that aim to understand the natural his...tory and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people. view more

    Research Areas: HIV, hepatitis C, liver diseases
  • Gregory Kirk Lab

    Research in the Gregory Kirk Lab examines the natural history of viral infections — particularl...y HIV and hepatitis viruses — in the U.S. and globally. As part of the ALIVE (AIDS Linked to the Intravenous Experience) study, our research looks at a range of pathogenetic, clinical behavioral issues, with a special focus on non-AIDS-related outcomes of HIV, including cancer and liver and lung diseases. We use imaging and clinical, genetic, epigenetic and proteomic methods to identify and learn more about people at greatest risk for clinically relevant outcomes from HIV, hepatitis B and hepatitis C infections. Our long-term goal is to translate our findings into targeted interventions that help reduce the disease burden of these infections. view more

    Research Areas: global health, Hepatitis, Africa, AIDS, cancer, HIV, drugs, liver diseases
  • Justin Bailey Lab

    Lab Website
    Principal Investigator:
    Justin Bailey, M.D., Ph.D.
    Medicine

    Research in the Justin Bailey Lab explores immune responses against hepatitis C virus (HCV), pa...rticularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. Recent studies have demonstrated that early and broad neutralizing antibody (nAb) responses against HCV are associated with HCV clearance, suggesting a key role for nAb in limiting HCV replication. The findings of this research will enhance understanding of how HIV infection may contribute to the lower rate of HCV clearance in HCV/HIV coinfected individuals, and the results could have implications for persistence of other viruses commonly occurring as coinfections with HIV. view more

    Research Areas: humoral immune response, vaccines, infectious disease, AIDS, HIV, hepatitis C
  • Kelly Gebo Lab

    Principal Investigator:
    Kelly Gebo, M.D., M.P.H.
    Medicine

    Work in the Kelly Gebo Lab focuses on topics such as evidence-based practice, health utilizatio...n, policy generation, health disparities in patient access to health care, HIV/AIDS, aging and hepatitis. As part of the HIV Research Network (HIVRN), our lab gathers clinical and demographic data on HIV-infected patients to help develop a single, nationwide research database. In addition, our ongoing research explores evidence-based practice in relation to the management of hepatitis C as well as HIV/AIDS in mentally ill patients. We also investigate racial and gender disparities in patients who receive highly active antiretroviral therapy. view more

    Research Areas: Hepatitis, AIDS, HIV, aging, health care policy, evidence-based medicine, health disparities
  • Mark Sulkowski Lab

    Lab Website
    Principal Investigator:
    Mark Sulkowski, M.D.
    Medicine

    Research in the Mark Sulkowski Lab focuses on hepatitis B and hepatitis C. We've conducted clin...ical research related to the management of viral hepatitis, including novel agents. Other studies focus on adult patients at the Johns Hopkins site of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hepatitis B Clinical Research Network as well as the National Institute of Allergy and Infectious Diseases Adult AIDS Clinical Trials Group. view more

    Research Areas: infectious disease, hepatitis B, hepatitis C
  • Michael Melia Lab

    Principal Investigator:
    Michael Melia, M.D.
    Medicine

    Research in the Michael Melia Lab focuses primarily on nocardia infections, Lyme disease and he...patitis C. Our studies have included key topics such as risk factors for incident infections during hepatitis C treatment, racial differences in eligibility for hepatitis C treatment and misdiagnosis of Lyme arthritis using the Borrelia burgdorferi immunoblot testing method. We also have a longstanding interest in medical education and work on curriculum to improve the quality of education for medical students and interns. view more

    Research Areas: medical education, nocardia infections, infectious disease, AIDS, HIV, Lyme disease, hepatitis C
  • Namandje N. Bumpus Lab

    Lab Website
    Principal Investigator:
    Namandje Bumpus, Ph.D.
    Medicine

    The Bumpus Laboratory uses mass spectrometry and molecular pharmacology-based approaches to stu...dy the biotransformation of clinically used drugs by the cytochromes P450s. Specifically, we are studying ways to define a role for cytochrome P450-dependent metabolites in the drug-induced acute liver failure that is associated with certain antiviral drugs used to treat HIV and hepatitis C. Our long-term goal is to gain information that can be used to develop therapies that are devoid of toxic events by preventing the formation of a toxic metabolite or by developing strategies for preventing toxicity using concomitant therapy. view more

    Research Areas: antiviral therapy, drug metabolism, mass spectrometry, HIV, drugs, cellular signaling, cytochromes P450, pharmacology, molecular pharmacology, hepatitis C, metabolomics
  • Saleh Alqahtani Lab

    Principal Investigator:
    Saleh Alqahtani, M.B.Ch.B., M.S.
    Medicine

    The Saleh Alqahtani Lab has conducted clinical research on the management of fatty liver diseas...e and viral hepatitis, including novel therapies. We’ve also been involved in various clinical trials related to liver cirrhosis, liver cancer and outcomes of liver transplant patients. view more

    Research Areas: fatty liver disease, Hepatitis, liver transplants, cirrhosis, liver diseases, liver cancer
  • Stuart C. Ray Lab

    Lab Website
    Principal Investigator:
    Stuart Ray, M.D.
    Medicine

    Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and a...n increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV. view more

    Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology
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