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Displaying 1 to 3 of 3 results for Head and neck squamous cell carcinoma

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  • Allen Lab

    The Allen Lab focuses on immunologic aspects of cancer development and progression, with a focus on head and neck squamous cell carcinoma, the most common form of head and neck cancer. Work also aims to translate key knowledge learned from our investigation into anti-tumor immunity to other diseases in otolaryngology, including inflammatory and infectious disorders.

    Research Areas: anti-tumor immunity, otolaryngology, cancer, head and neck cancer, Squamous cell carcinoma

  • Daria Gaykalova Lab

    The Daria Gakalova Lab defines the functional role of epigenetics in transcriptional regulation of head and neck squamous cell carcinoma (HNSCC) progression. To evaluate the whole-genome distribution of various histone marks, her team is using chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-Seq) for primary tissues, a method recently developed by her lab. The research group of Daria Gaykalova was the first to demonstrate the cancer-specific distribution of H3K4me3 and H3K27ac marks and their role in cancer-related gene expression in HNSCC. The research showed that an aberrant chromatin alteration is a central event in carcinogenesis and that the therapeutic control of chromatin structure can prevent the primary of secondary cancerization. Further preliminary data suggest that the differential enrichment of these disease-specific histone marks and DNA methylation correlate with alternative splicing events (ASE) formation. For this project, Dr. Gaykalova... and her team employed a novel bioinformatical tool for the detection of cancer-specific ASEs. Through thorough functional validation of the individual ASEs, the lab demonstrated that each of them has a unique mechanism of malignant transformation of the cells. Due to high disease specificity, ASEs represent the perfect biomarkers of the neoantigens and have direct application to clinical practice. view more

    Research Areas: Head and neck squamous cell carcinoma, Human papillomavirus, Alternative splicing, epigenetics, Chromatin structure, Cancer genomics, head and neck cancer

  • Nicole Schmitt Lab

    The Nicole Schmitt lab focuses on the mechanisms by which platinum-based chemotherapy works for head and neck squamous cell carcinoma. Current interests include immune and inflammatory mechanisms of cisplatin, and how these mechanisms are altered by the addition of radiotherapy and/or immunotherapy. Preclinical work is underway to help determine the best way to combine standard platinum-based chemoradiation therapy with immunotherapies and targeted therapies in clinical trials.

    Research Areas: radiotherapy, platinum-based chemotherapy, cisplatin, immunotherapy, Squamous cell carcinoma

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