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  • Amita Gupta Lab

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and other co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health.

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis

    Principal Investigator

    Amita Gupta, M.D.

    Department

    Medicine

  • Andrea Cox Lab

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design.

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells

    Principal Investigator

    Andrea Cox, M.D., Ph.D.

    Department

    Medicine

  • Anna Durbin Lab

    The Anna Durbin Lab evaluates experimental vaccines through human clinical trials. We have conducted both pediatric and adult clinical trials on vaccines for HIV, hepatitis C, HPV, influenza, malaria, dengue virus, rotavirus and other viruses. We also have a longstanding interest in better understanding the immunologic factors of dengue infection and disease. We’re working to identify the viral, host and immunologic factors that cause severe dengue illness.

    Research Areas: dengue fever, epidemiology, international health, vaccines, HPV, clinical trials, HIV, malaria, hepatitis C, flu

    Lab Website

    Principal Investigator

    Anna Durbin, M.D.

    Department

    Medicine

  • Anne Rompalo Lab

    Research in the Anne Rompalo Lab focuses on STD research and application. We recently examined the relationship between violence against women and HIV-related risk factors in women living in the United States. Past projects include a nine-year longitudinal observation study of HIV-infected women in Baltimore.

    Research Areas: women, HIV, sexually transmitted diseases, domestic violence

    Principal Investigator

    Anne Rompalo, M.D.

    Department

    Medicine

  • Ashwin Balagopal Lab

    Research in the Ashwin Balagopal Lab examines innate immunology and hepatic inflammation. Specifically, we explore microbial translocation Kupffer cells in HIV- hepatitis C virus (HCV) coinfection, while also developing in situ liver studies of HIV-HCV pathogenesis. Previous work has focused on antiretroviral therapy, interferon sensitivity and virologic setpoint in HIV/hepatitis C virus coinfected patients.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, HIV, hepatitis C

    Principal Investigator

    Ashwin Balagopal, M.D.

    Department

    Medicine

  • Bryan Lau Lab

    The Bryan Lau Lab is interested in epidemiological and statistical methods for cohort studies and the application of these methods primarily to HIV cohort studies. We’re particularly interested in developing new methods and using approaches from other disciplines as novel solutions to specific epidemiologic issues.

    Research Areas: epidemiology, cohort studies, AIDS, HIV, biostatistics

    Lab Website

    Principal Investigator

    Bryan Lau, Ph.D.

    Department

    Medicine

  • Charles Holmes Lab

    Researchers in the Charles Holmes Lab study large-scale strategies for improving information for public health decision-making and for developing more effective and efficient health care delivery models. This includes working on strategies to expand access to antiretroviral therapies and services aimed at preventing mother-to-child disease transmission, as well as methods to integrate evolving science into public health policy.

    Research Areas: antiretroviral therapies, infectious disease, medical decision making, HIV, public health, tuberculosis

    Principal Investigator

    Charles Holmes, M.D., M.P.H.

    Department

    Medicine

  • Charles W. Flexner Laboratory

    A. Laboratory activities include the use of accelerator mass spectrometry (AMS) techniques to measure intracellular drugs and drugs metabolites. AMS is a highly sensitive method for detecting tracer amounts of radio-labeled molecules in cells, tissues, and body fluids. We have been able to measure intracellular zidovudine triphosphate (the active anabolite of zidovudine) in peripheral blood mononuclear cells from healthy volunteers given small doses of 14C-zidovudine, and have directly compared the sensitivity of AMS to traditional LC/MS methods carried out in our laboratory.

    B. Clinical research activities investigate the clinical pharmacology of new anti-HIV therapies and drug combinations. Specific drug classes studied include HIV reverse transcriptase inhibitors, protease inhibitors, entry inhibitors (selective CCR5 and CXCR4 antagonists), and integrase inhibitors. Scientific objectives of clinical studies include characterization of early drug activity, toxicity, and pharmacok...inetics. Additional objectives are characterization of pathways of drug metabolism, and identification of clinically significant harmful and beneficial drug interactions mediated by hepatic and intestinal cytochrome P450 isoforms. view more

    Research Areas: antiretroviral drugs, infectious disease, HIV protease inhibitors, HIV, drugs, accelerator mass spectrometry

    Principal Investigator

    Charles Flexner, M.D.

    Department

    Medicine

  • Chloe Thio Lab

    Research in the Chloe Thio lab focuses on several areas. First, HBV virology and immunology in HBV monoinfected and HIV-HBV co-infected individuals that will ultimately help develop a cure for HBV. Second, HCV infection in men who have sex with men. Third, non-alcoholic fatty liver disease with a focus on HIV-infected individuals. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance.

    Research Areas: HIV-HBV co-infection, hepatitis B, genomics, hepatitis C, fatty liver

    Principal Investigator

    Chloe Thio, M.D.

    Department

    Medicine

  • Christian Merlo Lab

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients.

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

    Principal Investigator

    Christian Merlo, M.D., M.P.H.

    Department

    Medicine

  • Christine Durand Lab

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopkins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased ...donor liver transplantation. view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C

    Principal Investigator

    Christine Durand, M.D.

    Department

    Medicine

  • Clinical Laboratory and Biomarkers Core

    The Clinical Laboratory and Biomarkers Cores will coordinate access to laboratory expertise, testing, training, specimen repositories and Good Clinical Laboratory Practices (GCLP). The goals of this core are to assure that all JHU HIV investigators have access to and utilize appropriate, validated and, where applicable, certified laboratory assays. The core will also maintain a biomarker specimen repository for storage cataloguing and utilization of biological specimens.

    Research Areas: virology, immunology, biomarkers, HIV, pathogenesis

    Lab Website

    Principal Investigator

    Craig W. Hendrix, M.D.

    Department

    Medicine

  • Craig W. Hendrix Lab

    Research in the Craig W. Hendrix Lab concentrates on the chemoprevention of HIV infection, clinical pharmacology of antiviral drugs, drug interactions, and oral, topical and injectable HIV microbicide development. Our lab conducts small, intensive sampling studies of PK and PD of drugs for HIV prevention with a focus on developing methods to better understand HIV and drug distribution in the male genital tract, female genital tract and lower gastrointestinal tract. We also support numerous HIV pre-exposure prophylaxis development studies from phase I to phase III, largely as leader of the Pharmacology Core Laboratory of both the Microbicide Trial Network and HIV Prevention Trials Network.

    Research Areas: antiretroviral therapies, infectious disease, HIV, drugs

    Principal Investigator

    Craig W. Hendrix, M.D.

    Department

    Medicine

  • David Celentano Lab

    The David Celentano Lab studies behavioral and social epidemiology by integrating behavioral science theory and research with epidemiology methods. Our team directs epidemiological investigations and stages preventive interventions targeting HIV/AIDS and other sexually transmitted infections.

    Research Areas: epidemiology, opioids, AIDS, HIV, sexually transmitted diseases

    Principal Investigator

    David Celentano, Sc.D.

    Department

    Medicine

  • David Graham Lab

    The David Graham Lab studies the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions. We apply advanced technologies like mass spectrometry to dissect processes at the molecular level. We are also actively involved in cardiovascular research and studies the ways proteins are organized into functional units in different cell types of the heart.

    Major projects in our lab are organized into three major areas: (1) H/SIV pathogenesis and neuropathogenesis, (2) Cardiovascular disease, and (3) High technology development

    Research Areas: immunology, mass spectrometry, HIV, cardiovascular, SIV, pathogenesis

    Principal Investigator

    David Graham, M.S., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • David Holtgrave Lab

    Work in the David Holtgrave Lab primarily assesses the efficacy and cost-effectiveness of HIV prevention and care interventions in an effort to apply our findings to HIV prevention policy making. Our team also conducts research on the intersection of infectious disease rates, risk behavior prevalence and social capital measures. We have also studied the economic effectiveness of smoking interventions.

    Research Areas: smoking cessation, infectious disease, AIDS, HIV, economics, public policy

    Principal Investigator

    David Holtgrave, Ph.D.

    Department

    Medicine
    Oncology

  • David Thomas Lab

    The David Thomas Lab oversees clinical research projects that aim to understand the natural history and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people.

    Research Areas: HIV, hepatitis C, liver diseases

    Principal Investigator

    David Thomas, M.D., M.P.H.

    Department

    Medicine

  • Erica Johnson Lab

    Research in the Erica Johnson Lab investigates infection control in military deployment environments as well as infections that are associated with combat trauma. We explore topics such as HIV outcomes, gender-based health issues and disparities in care.

    Research Areas: gender-based health issues, infectious disease, combat trauma, HIV, deployment infection control, health disparities

    Lab Website

    Principal Investigator

    Erica Johnson, M.D.

    Department

    Medicine

  • Ernesto Freire Laboratory

    The Ernesto Freire Lab studies the use of novel drugs to treat disease. Our research has resulted in the development of a thermodynamic platform for drug discovery and optimization. Our aim is to achieve high binding affinity and selectivity as well as appropriate pharmacokinetics with the platform. We are currently focusing on drug targets such as HIV/-1 protease inhibitors (HIV/AIDS), plasmepsin inhibitors (malaria), HCV protease inhibitors (hepatitis C), coronavirus 3CL-pro protease inhibitors (SARS and other viral infections), HIV-1 gp120 inhibitors (HIV/AIDS), chymase inhibitors (cardiovascular disease) and beta lactamase inhibitors (antibiotic resistance).

    Research Areas: pharmaceuticals, thermodynamics, AIDS, drug discovery, HIV, protease inhibitors, malaria

  • Gail Berkenblit Lab

    The Gail Berkenblit Lab focuses on HIV testing. We are particularly interested in the training of residents as it relates to HIV outpatient care, and the development and assessment of online curriculum.

    Research Areas: medical education, HIV

    Principal Investigator

    Gail Berkenblit, M.D., Ph.D.

    Department

    Medicine

  • Geetanjali Chander Lab

    Our research focuses at the nexus of HIV and alcohol and other substance use. We examine epidemiological aspects of HIV and alcohol use/other drug use among persons with HIV (PWH), and work on the adaptation and testing of person and computer-delivered interventions for unhealthy alcohol use, particularly among women.

    Research Areas: Ressearch at the intersection of alcohol and other substance use and HIV, intervention, substance abuse, alcohol use, HIV, hepatitis C

    Principal Investigator

    Geetanjali Chander, M.D., M.P.H.

    Department

    Medicine

  • Gregory Kirk Lab

    Research in the Gregory Kirk Lab examines the natural history of viral infections — particularly HIV and hepatitis viruses — in the U.S. and globally. As part of the ALIVE (AIDS Linked to the Intravenous Experience) study, our research looks at a range of pathogenetic, clinical behavioral issues, with a special focus on non-AIDS-related outcomes of HIV, including cancer and liver and lung diseases. We use imaging and clinical, genetic, epigenetic and proteomic methods to identify and learn more about people at greatest risk for clinically relevant outcomes from HIV, hepatitis B and hepatitis C infections. Our long-term goal is to translate our findings into targeted interventions that help reduce the disease burden of these infections.

    Research Areas: global health, Hepatitis, Africa, AIDS, cancer, HIV, drugs, liver diseases

    Principal Investigator

    Gregory Kirk, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Haughey Lab: Neurodegenerative and Neuroinfectious Disease

    Dr. Haughey directs a disease-oriented research program that address questions in basic neurobiology, and clinical neurology. The primary research interests of the laboratory are:

    1. To identify biomarkers markers for neurodegenerative diseases including HIV-Associated Neurocognitive Disorders, Multiple Sclerosis, and Alzheimer’s disease. In these studies, blood and cerebral spinal fluid samples obtained from ongoing clinical studies are analyzed for metabolic profiles through a variety of biochemical, mass spectrometry and bioinformatic techniques. These biomarkers can then be used in the diagnosis of disease, as prognostic indicators to predict disease trajectory, or as surrogate markers to track the effectiveness of disease modifying interventions.
    2. To better understand how the lipid components of neuronal, and glial membranes interact with proteins to regulate signal transduction associated with differentiation, motility, inflammatory signaling, survival, and neuronal excitab...ility.
    3. To understand how extracellular vesicles (exosomes) released from brain resident cells regulate neuronal excitability, neural network activity, and peripheral immune responses to central nervous system damage and infections.
    4. To develop small molecule therapeutics that regulate lipid metabolism as a neuroprotective and restorative strategy for neurodegenerative conditions.
    view more

    Research Areas: multiple sclerosis, PTSD, HAND, HIV

    Lab Website

    Principal Investigator

    Norman Haughey, Ph.D.

    Department

    Neurology
    Neurosurgery

  • Healthy Brain Program

    The Brain Health Program is a multidisciplinary team of faculty from the departments of neurology, psychiatry, epidemiology, and radiology lead by Leah Rubin and Jennifer Coughlin. In the hope of revealing new directions for therapies, the group studies molecular biomarkers identified from tissue and brain imaging that are associated with memory problems related to HIV infection, aging, dementia, mental illness and traumatic brain injury. The team seeks to advance policies and practices to optimize brain health in vulnerable populations while destigmatizing these brain disorders.

    Current and future projects include research on: the roles of the stress response, glucocorticoids, and inflammation in conditions that affect memory and the related factors that make people protected or or vulnerable to memory decline; new mobile apps that use iPads to improve our detection of memory deficits; clinical trials looking at short-term effects of low dose hydrocortisone and randomized to 28 day...s of treatment; imaging brain injury and repair in NFL players to guide players and the game; and the role of inflammation in memory deterioration in healthy aging, patients with HIV, and other neurodegenerative conditions. view less

    Research Areas: HIV infection, mental illness, aging, traumatic brain injury, dementia

  • HIV Quality of Care

    Dr. Stephen Berry’s research focuses on healthcare quality, safety and costs among persons living with HIV, both in the outpatient and inpatient settings. He conducts observational and interventional studies of sexually transmitted infection screening in HIV clinics, with a focus on improving performance to meet national guidelines. He leads observational studies of rates and reasons for hospitalizations and of 30-day readmission rates among HIV patients. He is conducting a randomized study of a nurse- and pharmacist-based team to reduce inpatient HIV medication errors and increase engagement in outpatient care among persons living with HIV who are hospitalized at The Johns Hopkins Hospital.

    Research Areas: health care quality, safety, HIV, sexually transmitted diseases

    Principal Investigator

    Stephen Berry, M.D.

    Department

    Medicine

  • Hoffmann Lab

    The Hoffmann Lab is focused on reducing TB and HIV morbidity and mortality in the low and middle income settings through behavioral and implementation science approaches. Work has focused on understanding individual-level behavior towards linkage to care and continued care engagement for HIV and TB and using this knowledge to develop approaches to increase HIV testing, linkage to care, HIV viral load suppression, and retention in care. Other work has focused on health system strategies to improve service delivery and improve adherence to best practice to guidelines-based care. The group's research includes work on the general population, corrections inmates and ex-inmates, men at risk for HIV, and recently hospitalized individuals. Most of the research has been in South Africa and elsewhere in sub-Saharan Africa.

    Research Areas: care continuum, HIV, behavioral health, implementation science, tuberculosis

    Principal Investigator

    Christopher Hoffmann, M.D., M.P.H.

    Department

    Medicine

  • HPTN (HIV Prevention Trials Network) Network Lab

    HPTN (HIV Prevention Trials Network) Network Laboratory (NL) is responsible for collecting, testing and reporting results from biological samples; assisting in the development and quality assurance assessment of local laboratory capacity at the Clinical Trials Units (CTUs) participating in HPTN clinical trials (www.hptn.org); and identifying and implementing state-of-the-art assays and technologies to advance the scientific agenda of the Network.

    Research Areas: microbiology, blood disorders, molecular pathology, immunology, cytogenetics, HIV, transfusion medicine, chemistry

    Lab Website

    Principal Investigator

    Susan Eshleman, M.D., Ph.D.

    Department

    Pathology

  • Janet Siliciano Lab

    Research in the Janet Siliciano lab focuses on HIV. Areas of study include CD4-positive T lymphocytes, virus latency and highly active antiretrovirals. We recently explored the challenges of detecting HIV persistence during potentially curative interventions and the multifactorial nature of HIV-1 latency.

    Research Areas: antiretroviral therapies, HIV, T lymphocytes

    Principal Investigator

    Janet Siliciano, Ph.D.

    Department

    Medicine

  • Jeremy Sugarman Lab

    Research in the Jeremy Sugarman Lab focuses on biomedical ethics—particularly, the application of empirical methods and evidence-based standards to the evaluation and analysis of bioethical issues. Our contributions to medical ethics and health policy include work on the ethics of informed consent, umbilical cord blood banking, stem cell research, international HIV prevention research, global health and research oversight.

    Research Areas: global health, medical ethics, stem cells, HIV, evidence-based medicine, bioethics

    Principal Investigator

    Jeremy Sugarman, M.A., M.D., M.P.H.

    Department

    Medicine

  • JHU NIMH Research Center

    The Johns Hopkins NIMH Center is comprised of an interdisciplinary research team who has pooled their talents to study the nature of HIV-associated neurocognitive disorders (HAND). Their aim is to translate discoveries of the pathophysiological mechanisms into novel therapeutics for HAND.Our objectives are to integrate aspects of ongoing research in HAND and SIV encephalitis; to develop high-throughput and screening assays for identifying novel therapeutic compounds; to use proteomics and lipidomics approaches to indentifying surrogate markers of disease activity; to disseminate information and education about HAND through existing and new educational systems, including the JHU AIDS Education Training Center and the JHU Center for Global Clinical Education and to facilitate the entry of new investigators into neuro-AIDS research, and to catalyze new areas of research, particularly where relevant for drug discovery or the development of validated surrogate markers.

    Research Areas: neuropathy, HAND, AIDS dementia complex, myopathy, myelopathy, HIV-associated neurocognitive disorders

    Lab Website

    Principal Investigator

    Justin McArthur, M.B.B.S., M.P.H.

    Department

    Neurology

  • Joel Blankson Lab

    Work in the Joel Blankson Lab explores the mechanism of control of HIV-1 replication in a cohort of patients known as elite controllers or elite suppressors. These patients are HIV-1 seropositive but maintain levels of viremia that are below the limit of detection of standard clinical assays. We feel that elite suppressors represent a potential model for a therapeutic HIV vaccine. Our central hypothesis is that many of these patients are infected with fully replication-competent HIV-1 isolates that are held in check by the immune system. To test this hypothesis, we are studying many different host and viral factors in these patients.

    Research Areas: vaccines, infectious disease, HIV, pathogenesis, elite suppressors

    Principal Investigator

    Joel Blankson, M.D., Ph.D.

    Department

    Medicine

  • Johns Hopkins NIMH Center for Novel Therapeutics of HIV-associated Cognitive Disorders

    The Johns Hopkins NIMH Center for Novel Therapeutics of HIV-associated Cognitive Disorders is an interdisciplinary team of researchers who work together to study the nature of HIV-association neurocognitive disorders (HAND). The goal of their research is to translate discoveries of the pathophysiological mechanisms into new therapies for HAND.

    Research Areas: cognition, HIV, neurocognitive disorders

    Lab Website

    Principal Investigator

    Justin McArthur, M.B.B.S., M.P.H.

    Department

    Neurology

  • Jonathan Golub Lab

    Research in the Jonathan Golub Lab focuses primarily on the epidemiology of tuberculosis (TB), specifically in patients infected with HIV. We work with the CDC to explore potential delays in TB diagnoses as well as the risk factors that contribute to death from TB in the United States. Our research also includes ongoing studies of HIV and TB patients in Brazil and South Africa.

    Research Areas: epidemiology, infectious disease, AIDS, HIV, tuberculosis

    Principal Investigator

    Jonathan Golub, M.P.H., Ph.D.

    Department

    Medicine

  • Joseph Cofrancesco Jr. Lab

    Research in the Joseph Cofrancesco Jr. Lab focuses primarily on health care for HIV-positive patients. Our recent studies have explored topics such as HIV antiretroviral treatments, HIV resistance and the long-term complications of HIV treatment. In addition, we are part of the U.S. Fat Redistribution and Metabolism (FRAM) study and have had a long-standing involvement in projects that examine metabolic and fat complications in Thailand.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, disease resistance, metabolism, HIV

    Principal Investigator

    Joseph Cofrancesco, M.D., M.P.H.

    Department

    Medicine

  • Joseph Mankowski Lab

    The Joseph Mankowski Lab studies the immunopathogenesis of HIV infection using the SIV/macaque model. Our researchers use a multidisciplinary approach to dissect the mechanism underlying HIV-induced nervous system and cardiac diseases. Additionally, we study the role that host genetics play in HIV-associated cognitive disorders.

    Research Areas: macaques, HIV, genomics, SIV, pathogenesis, cardiology, nervous system

    Principal Investigator

    Joseph L. Mankowski, D.V.M., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Joseph Margolick Lab

    Research in the Joseph Margolick Lab focuses on the many effects of HIV/AIDS on human health. We are particularly interested in the mechanisms of T-cell loss and preservation among people infected with HIV and the evaluation of human immune functions.

    Research Areas: immunology, AIDS, HIV, pathogenesis, T cells

    Principal Investigator

    Joseph Margolick, M.D., Ph.D.

    Department

    Medicine

  • Justin Bailey Lab

    Research in the Justin Bailey Lab explores immune responses against hepatitis C virus (HCV), particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. Recent studies have demonstrated that early and broad neutralizing antibody (nAb) responses against HCV are associated with HCV clearance, suggesting a key role for nAb in limiting HCV replication. The findings of this research will enhance understanding of how HIV infection may contribute to the lower rate of HCV clearance in HCV/HIV coinfected individuals, and the results could have implications for persistence of other viruses commonly occurring as coinfections with HIV.

    Research Areas: humoral immune response, vaccines, infectious disease, AIDS, HIV, hepatitis C

    Lab Website

    Principal Investigator

    Justin Bailey, M.D., Ph.D.

    Department

    Medicine

  • Kathleen Page Lab

    Research in the Kathleen Page Lab examines the impact of bovine colostrum (BC) on immune activation and HIV susceptibility, and aims to develop a point-of-care diagnostic test for histoplasmosis.

    Research Areas: histoplasmosis, infectious disease, HIV, Hispanic Americans

    Principal Investigator

    Kathleen Page, M.D.

    Department

    Medicine

  • Kathryn Carson Lab

    The Kathryn Carson Lab investigates ways to improve medical research, particularly in the areas of brain and thyroid cancer, Alzheimer’s disease, atherosclerosis, hypertension, HIV and lupus. Our team seeks to help researchers optimize their studies through better study design, protocol and grant writing, data cleaning and analysis, and publication writing. We work with investigators from a wide range of departments through the Johns Hopkins Institute for Clinical and Translational Research.

    Research Areas: epidemiology, lupus, research methods, data analysis, cancer, hypertension, clinical trials, HIV, biostatistics, Alzheimer's disease

    Principal Investigator

    Kathryn Carson, Sc.M.

    Department

    Medicine

  • Kelly E. Dooley Laboratory

    Research focuses on clinical pharmacology of new anti-tuberculosis regimens with an emphasis on: (1) Phase I clinical trials of new or existing anti-TB drugs including dose escalation trials and studies of drug-drug interactions between anti-TB agents and antiretrovirals to treat HIV; (2) Use of PK/PD analysis and modelling in Phase II tuberculosis clinical treatment trials to determine concentration-effect relationships that will allow for optimization of dosing; and (3) Evaluation of TB and HIV drug concentrations in special populations, such as pregnant women and children; (4) Evaluation of treatment-shortening regimens for drug-sensitive TB and investigational regimens for treatment of multidrug-resistant TB; and (5) Translational work involving novel animal models of cavitary pulmonary TB disease to understand drug distribution in diseased lung.

    Research Areas: anti-infective drugs, antiretroviral therapies, tuberculosis and HIV treatments, HIV, lung disease, pharmacology, tuberculosis

    Lab Website

    Principal Investigator

    Kelly Dooley, M.D., M.P.H., Ph.D.

    Department

    Medicine

  • Kelly Gebo Lab

    Work in the Kelly Gebo Lab focuses on topics such as evidence-based practice, health utilization, policy generation, health disparities in patient access to health care, HIV/AIDS, aging and hepatitis. As part of the HIV Research Network (HIVRN), our lab gathers clinical and demographic data on HIV-infected patients to help develop a single, nationwide research database. In addition, our ongoing research explores evidence-based practice in relation to the management of hepatitis C as well as HIV/AIDS in mentally ill patients. We also investigate racial and gender disparities in patients who receive highly active antiretroviral therapy.

    Research Areas: Hepatitis, AIDS, HIV, aging, health care policy, evidence-based medicine, health disparities

    Principal Investigator

    Kelly Gebo, M.D., M.P.H.

    Department

    Medicine

  • Ken Witwer Laboratory

    The Ken Witwer Laboratory investigates extracellular vesicles and RNA in the context of HIV infection and inflammatory disease. We are also actively assessing the effects of diet on extracellular RNA as a potential therapeutic approach.

    Research Areas: extracellular vesicles, HIV, inflammation, RNA

    Principal Investigator

    Kenneth Witwer, Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • Kenrad Nelson Lab

    Research in the Kenrad Nelson Lab focuses on diseases such as hepatitis, HIV/AIDS, leprosy, nosocomial infections, tuberculosis and infections in drug users. We study populations including HIV/AIDS patients, injection drug users, blood donors and transfusion recipients in the United States as well as in China, Thailand, Bangladesh and the Republic of Georgia. We are currently investigating the connection between HIV infection and drug use as part of the ALIVE study.

    Research Areas: Hepatitis, AIDS, blood donors, HIV, drug users, leprosy, tuberculosis, nosocomial infections

    Principal Investigator

    Kenrad Nelson, M.D.

    Department

    Medicine

  • Lana Lee Lab

    The Lana Lee Lab works to create successful patient-centered care strategies for young individuals living with HIV. We focus in particular on decision making in HIV treatment for youth and on the availability of services for young people living with HIV in the United States and Uganda.

    Research Areas: patient-centered health care, medical decision making, HIV, care coordination

    Principal Investigator

    Lana Lee, M.D.

    Department

    Pediatrics

  • Larry Chang Lab

    Research in the Larry Chang Lab focuses on innovative, multidisciplinary and pragmatic approaches to impacting the HIV/AIDS pandemic. Our research investigates ways to improve HIV/AIDS care in low- and middle-income settings through strategies that include quantitative methods, qualitative methods, community-based trial designs, and behavioral science and economic evaluations. In addition, we research mobile technologies for health (mHealth) strategies for improving global public health and clinical care, including novel applications for intimate-partner violence intervention, dengue surveillance, and HIV care, surveillance and prevention.

    Research Areas: global health, infectious disease, AIDS, HIV, mHealth

    Principal Investigator

    Larry Chang, M.D., M.P.H.

    Department

    Medicine

  • Marvel Cognitive Neuropsychiatric Research Laboratory

    The Cognitive Neuropsychiatric Research Laboratory (CNRLab) is part of the Division of Cognitive Neuroscience within the Department of Neurology at the Johns Hopkins University School of Medicine. Its current projects include investigating the motor system's contribution to cognitive function; HIV-related neuroplasticity and attention-to-reward as predictors of real world function; and brain function and cognition in Lyme disease.

    Research Areas: HIV, neuroplasticity, movement disorders, cognitive function

    Lab Website

    Principal Investigator

    Cherie Marvel, Ph.D.

    Department

    Neurology

  • Mary Catherine Beach Lab

    Research in the Mary Catherine Beach Lab focuses on physician mindfulness and the patient-provider relationship and how such factors impact health care quality. Current research involves investigating the theoretical foundations of respect, as well as the impact of physician attitudes and communication on patients in the primary care setting, with a specific focus on HIV, substance abuse and sickle cell disease patients. We also explore issues such as patients’ rights, mental health parity, human subject protection, genetic discrimination, human cloning and stem cell research.

    Research Areas: physician mindfulness, mental health, sickle cell diseases, substance abuse, patient-provider relationships, HIV, patients’ rights

    Principal Investigator

    Mary Catherine Beach, M.D., M.P.H.

    Department

    Medicine

  • Maunank Shah Lab

    Work in the Maunank Shah Lab focuses on infectious disease modeling and health economics, and seeks to investigate new strategies for diagnosing HIV and tuberculosis (TB) in areas with limited resources, both domestically and abroad. Our primary focus is TB diagnostics, with studies examining the diagnostic test accuracy, cost-effectiveness and programmatic impact of emerging diagnostics. We have developed mobile health initiatives to incorporate video-based therapy for TB treatment, and we have a longstanding interest in interventions that help to reduce or prevent HIV transmission.

    Research Areas: health economics, mobile health, infectious disease, AIDS, HIV, tuberculosis

    Lab Website

    Principal Investigator

    Maunank Shah, M.D.

    Department

    Medicine

  • Michael Melia Lab

    Research in the Michael Melia Lab focuses primarily on nocardia infections, Lyme disease and hepatitis C. Our studies have included key topics such as risk factors for incident infections during hepatitis C treatment, racial differences in eligibility for hepatitis C treatment and misdiagnosis of Lyme arthritis using the Borrelia burgdorferi immunoblot testing method. We also have a longstanding interest in medical education and work on curriculum to improve the quality of education for medical students and interns.

    Research Areas: medical education, nocardia infections, infectious disease, AIDS, HIV, Lyme disease, hepatitis C

    Principal Investigator

    Michael Melia, M.D.

    Department

    Medicine

  • Mohamed Atta Lab

    Research in the Mohamed Atta Lab focuses on kidney diseases in patients with HIV. We recently reviewed the published nephrotoxic effects of newer antiviral therapies for HIV and hepatitis C, specifically looking at the role of epithelial organic transporters in explaining renal toxicities. We also examined the relationship between the APOL1 genotype and renal histology among black patients with HIV who had undergone kidney biopsies.

    Research Areas: kidney diseases, HIV, hepatitis C

    Principal Investigator

    Mohamed Atta, M.B.B.Ch., M.D., M.P.H.

    Department

    Medicine

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