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Research Lab Results for HIV

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  • Lana Lee Lab

    Principal Investigator:
    Lana Lee, M.D.
    Pediatrics

    The Lana Lee Lab works to create successful patient-centered care strategies for young individu...als living with HIV. We focus in particular on decision making in HIV treatment for youth and on the availability of services for young people living with HIV in the United States and Uganda. view more

    Research Areas: patient-centered health care, medical decision making, HIV, care coordination
  • Larry Chang Lab

    Principal Investigator:
    Larry Chang, M.D., M.P.H.
    Medicine

    Research in the Larry Chang Lab focuses on innovative, multidisciplinary and pragmatic approach...es to impacting the HIV/AIDS pandemic. Our research investigates ways to improve HIV/AIDS care in low- and middle-income settings through strategies that include quantitative methods, qualitative methods, community-based trial designs, and behavioral science and economic evaluations. In addition, we research mobile technologies for health (mHealth) strategies for improving global public health and clinical care, including novel applications for intimate-partner violence intervention, dengue surveillance, and HIV care, surveillance and prevention. view more

    Research Areas: global health, infectious disease, AIDS, HIV, mHealth
  • Marvel Cognitive Neuropsychiatric Research Laboratory

    Lab Website
    Principal Investigator:
    Cherie Marvel, Ph.D.
    Neurology

    The Cognitive Neuropsychiatric Research Laboratory (CNRLab) is part of the Division of Cognitiv...e Neuroscience within the Department of Neurology at the Johns Hopkins University School of Medicine. Its current projects include investigating the motor system's contribution to cognitive function; HIV-related neuroplasticity and attention-to-reward as predictors of real world function; and brain function and cognition in Lyme disease. view more

    Research Areas: HIV, neuroplasticity, movement disorders, cognitive function
  • Mary Catherine Beach Lab

    Lab Website

    Research in the Mary Catherine Beach Lab focuses on humanizing healthcare through investigation... of patient-provider communication and relationships. Current research involves investigating the theoretical foundations of respect, as well as the impact of physician attitudes and communication on patients in the primary care setting, with a specific focus on HIV, substance abuse and sickle cell disease patients. view more

    Research Areas: Patient-Clinician Communication, Respect
  • Mohamed Atta Lab

    Dr. Atta and his research team explore the epidemiological and clinical interventions of a vari...ety of kidney diseases. Our goal is not only to advance the understanding of many kidney diseases but also to capitalize on novel discoveries of basic science to treat a wide range of rare and common kidney disorders.




    • Multi-international observational study of a rare form of amyloid (LECT2 amyloid) to understand its natural history with the ultimate interest of treating this condition.

    • Our group has launched a project investigating the impact of COVID19 on the kidney to identify risk factors influencing outcome across different clinical phenotypes

    • In collaboration with the Division of Infectious Diseases and the School of Public Health, our research has focused on the epidemiology of HIV and kidney disease. We also study clinical markers and contributing factors in the progression of kidney disease, and the association between kidney disease and heart disease.

    • Our research group is participating in a multicenter consortium serving as a clinical core site to study the pathogenesis of HIV-associated kidney disease by providing well-characterized clinical specimens and corresponding clinical and laboratory data.

    view more

    Research Areas: kidney diseases, HIV, hepatitis C
  • Namandje N. Bumpus Lab

    Lab Website
    Principal Investigator:
    Namandje Bumpus, Ph.D.
    Medicine

    The Bumpus Laboratory uses mass spectrometry and molecular pharmacology-based approaches to stu...dy the biotransformation of clinically used drugs by the cytochromes P450s. Specifically, we are studying ways to define a role for cytochrome P450-dependent metabolites in the drug-induced acute liver failure that is associated with certain antiviral drugs used to treat HIV and hepatitis C. Our long-term goal is to gain information that can be used to develop therapies that are devoid of toxic events by preventing the formation of a toxic metabolite or by developing strategies for preventing toxicity using concomitant therapy. view more

    Research Areas: antiviral therapy, drug metabolism, mass spectrometry, HIV, drugs, cellular signaling, cytochromes P450, pharmacology, molecular pharmacology, hepatitis C, metabolomics
  • Neuroimmunopathology Lab

    The research activities of the Neuroimmunopathology Laboratory focus on studies of immunologica...l and molecular mechanisms involved in the pathogenesis of neurological disorders. Our main areas of research include studies of neurological complications of HIV infection and AIDS, multiple sclerosis, transverse myelitis, autism and epilepsy. We seek to explore and identify immunopathological mechanisms associated with neurological disease that may be the target of potential therapeutic interventions. The laboratory collaborates with other researchers and laboratories at Johns Hopkins and other institutions in projects related with studies of the interaction between the immune and central nervous systems in pathological processes leading to neurological dysfunction. view more

    Research Areas: multiple sclerosis, autism, epilepsy, HIV, transverse myelitis
  • Philip Smith Lab

    Principal Investigator:
    Philip Smith, M.D.
    Medicine

    Work in the Philip Smith Lab explores several key topics within the field of sleep medicine. We... investigate the role of obesity and neural control in sleep-disordered breathing as well as the impact of metabolic function on sleep apnea. We also research the ways in which HIV and its treatments impact a patient’s sleep. Our studies have included the effects of HIV and highly active antiretroviral therapy (HAART) on both sleep and daytime function as well as the relationship between systemic inflammation and sleep apnea in men with HIV. view more

    Research Areas: AIDS, sleep medicine, obesity, HIV, metabolic function, sleep apnea
  • Retrovirus Laboratory

    Principal Investigator:
    Janice Clements, Ph.D.
    Molecular and Comparative Pathobiology

    Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of len...tivirus infections. In particular, we study the simian immunodeficiency virus (SIV) to determine the molecular basis for the development of HIV CNS, pulmonary and cardiac disease.

    Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. We are also interested in studies of lentivirus replication in macrophages and astrocytes and their role in the development of disease. These studies have led us to identify the viral genes that are important in neurovirulence of SIV and the development of CNS disease including NEF and the TM portion of ENV. The mechanisms of the action of these proteins in the CNS are complex and are under investigation. We have also developed a rapid, consistent SIV/macaque model in which we can test the ability of various antiviral and neuroprotective agents to reduce the severity of CNS and pulmonary disease.
    view more

    Research Areas: HIV, genomics, pulmonology, SIV, cardiology, lentivirus
  • Richard Chaisson Lab

    Principal Investigator:
    Richard Chaisson, M.D.
    Medicine

    Research in the Richard Chaisson Lab primarily examines tuberculosis and HIV infection, with sp...ecific focus on global epidemiology, clinical trials, diagnostics and public health interventions. Our recent research has involved evaluating a molecular diagnostic test for tuberculosis in HIV patients; observing TB responses during treatment of pulmonary tuberculosis; and examining antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. view more

    Research Areas: global health, epidemiology, infectious disease, AIDS, HIV, tuberculosis
  • Richard Moore Lab

    Principal Investigator:
    Richard Moore, M.D.
    Medicine

    Research interests in the Richard Moore Lab include clinical epidemiology, costs, cost-effectiv...eness and outcomes of HIV/AIDS. We recently examined whether the effect of delaying antiretroviral therapy initiation in HIV-positive adults is modified by age at entry into care. view more

    Research Areas: epidemiology, antiretroviral therapies, AIDS, HIV
  • Robert Bollinger Lab

    Principal Investigator:
    Robert Bollinger, M.D., M.P.H.
    Medicine

    The key research interests in the Robert Bollinger Lab include identifying biological and behav...ioral risk factors for HIV transmission as well as characterizing the clinical progression and treatment of HIV and related infectious diseases. We also have a long-standing interest in optimizing health care capacity and delivery in settings with limited resources. Our work includes implementing science research projects to explore the effectiveness of initiatives such as task-shifting, clinical education, distance learning and mobile health programs as a way to improve health care in these locations. view more

    Research Areas: mobile health, international health, infectious disease, HIV, public health, point-of-care diagnostics, tropical medicine, tuberculosis, health care capacity
  • Robert H. Brown Lab

    Lab Website

    Work in the Robert H. Brown Lab explores several topics within pulmonary physiology, with a lon...g-term goal of understanding the structural changes in the lungs that lead to the pathophysiology of lung disease. Our core studies examine the structure-function relationship of pulmonary airways and vessels as well as their role in chronic obstructive pulmonary disease (COPD) and reactive airway disease. Recent research has involved studying the mechanisms and treatment of COPD progression, new methods for treating asthma, and lung inflation and airway hyperresponsiveness. We are also exploring the impact of HIV infection on the etiology of lung disease and the pathophysiologic consequences of lung distention. view more

    Research Areas: asthma, HIV, pulmonary physiology, lung disease, COPD, reactive airway disease
  • Robert Siliciano Laboratory

    Principal Investigator:
    Robert Siliciano, M.D., Ph.D.
    Medicine

    Research in the Robert Siliciano Laboratory focuses on HIV and antiretroviral therapy (ART). AR...T consists of combinations of three drugs that inhibit specific steps in the virus life cycle. Though linked to reduced morbidity and mortality rates, ART is not curative. Through our research related to latently infected cells, we've shown that eradicating HIV-1 infection with ART alone is impossible due to the latent reservoir for HIV-1 in resting CD4+ T cells.

    Our laboratory characterized the different forms of HIV-1 that persist in patients on ART. Currently, we are searching for and evaluating drugs that target the latent reservoir. We are also developing assays that can be used to monitor the elimination of this reservoir. We are also interested in the basic pharmacodynamic principles that explain how antiretroviral drugs work. We have recently discovered why certain classes of antiretroviral drugs are so effective at inhibiting viral replication. We are using this discovery along with experimental and computational approaches to develop improved therapies for HIV-1 infection and to understand and prevent drug resistance. Finally, we are studying the immunology of HIV-1 infection, and in particular, the ability of some patients to control the infection without ART.
    view more

    Research Areas: antiretroviral therapies, HIV, drugs, pharmacology, drug resistance, T cells
  • Ronald Schnaar Lab

    The Ronald Schnaar Lab is involved in the rapidly expanding field of glycobiology, which studie...s cell surface glycans, lectins, and their roles in cell physiology.

    Current projects in our lab study include (1) Glycans and glycan-binding proteins in inflammatory lung diseases, (2) Ganglioside function in the brain, and (3) HIV-Tat and HIV-associated neurocognitive disorders.
    view more

    Research Areas: cell physiology, HIV, neurocognitive disorders, glycobiology
  • Stivers Lab

    Lab Website

    The Stivers Lab is broadly interested in the biology of the RNA base uracil when it is present ...in DNA. Our work involves structural and biophysical studies of uracil recognition by DNA repair enzymes, the central role of uracil in adapative and innate immunity, and the function of uracil in antifolate and fluoropyrimidine chemotherapy. We use a wide breadth of structural, chemical, genetic and biophysical approaches that provide a fundamental understanding of molecular function. Our long-range goal is to use this understanding to design novel small molecules that alter biological pathways within a cellular environment. One approach we are developing is the high-throughput synthesis and screening of small molecule libraries directed at important targets in cancer and HIV-1 pathogenesis. view more

    Research Areas: biophysics, enzymes, cell biology, uracil, cancer, HIV, DNA, RNA
  • Stuart C. Ray Lab

    Lab Website
    Principal Investigator:
    Stuart Ray, M.D.
    Medicine

    Chronic viral hepatitis (due to HBV and HCV) is a major cause of liver disease worldwide, and a...n increasing cause of death in persons living with HIV/AIDS. Our laboratory studies are aimed at better defining the host-pathogen interactions in these infections, with particular focus on humoral and cellular immune responses, viral evasion, inflammation, fibrosis progression, and drug resistance. We are engaged in synthetic biology approaches to rational vaccine development and understanding the limits on the extraordinary genetic variability of HCV. view more

    Research Areas: immunology, Hepatitis, AIDS, HIV, hepatitis B, hepatitis C, liver diseases, synthetic biology
  • Todd Brown Lab

    Principal Investigator:
    Todd Brown, M.D., Ph.D.
    Medicine

    The Todd Brown Lab focuses on metabolic, endocrine and skeletal abnormalities in HIV-infected p...atients, particularly as these factors relate to aging. Our studies take an epidemiologic approach to understanding the occurrence and prevalence of insulin resistance, diabetes, and anthropometric changes in HIV patients and their relationship to antiretroviral treatment. view more

    Research Areas: antiretroviral therapies, insulin resistance, metabolism, HIV, diabetes, endocrinology, skeletal abnormalities
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