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Displaying 1 to 20 of 68 results for HIV

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  • Amita Gupta Lab

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and other co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health.

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis

    Principal Investigator

    Amita Gupta, M.D.

    Department

    Medicine

  • Andrea Cox Lab

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of protective immunity against HCV infection and improve HCV vaccine design.

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells

    Principal Investigator

    Andrea Cox, M.D., Ph.D.

    Department

    Medicine

  • Anna Durbin Lab

    The Anna Durbin Lab evaluates experimental vaccines through human clinical trials. We have conducted both pediatric and adult clinical trials on vaccines for HIV, hepatitis C, HPV, influenza, malaria, dengue virus, rotavirus and other viruses. We also have a longstanding interest in better understanding the immunologic factors of dengue infection and disease. We’re working to identify the viral, host and immunologic factors that cause severe dengue illness.

    Research Areas: dengue fever, epidemiology, international health, vaccines, HPV, clinical trials, HIV, malaria, hepatitis C, flu

    Lab Website

    Principal Investigator

    Anna Durbin, M.D.

    Department

    Medicine

  • Anne Rompalo Lab

    Research in the Anne Rompalo Lab focuses on STD research and application. We recently examined the relationship between violence against women and HIV-related risk factors in women living in the United States. Past projects include a nine-year longitudinal observation study of HIV-infected women in Baltimore.

    Research Areas: women, HIV, sexually transmitted diseases, domestic violence

    Principal Investigator

    Anne Rompalo, M.D.

    Department

    Medicine

  • Ashwin Balagopal Lab

    Research in the Ashwin Balagopal Lab examines innate immunology and hepatic inflammation. Specifically, we explore microbial translocation Kupffer cells in HIV- hepatitis C virus (HCV) coinfection, while also developing in situ liver studies of HIV-HCV pathogenesis. Previous work has focused on antiretroviral therapy, interferon sensitivity and virologic setpoint in HIV/hepatitis C virus coinfected patients.

    Research Areas: antiretroviral therapies, infectious disease, AIDS, HIV, hepatitis C

    Principal Investigator

    Ashwin Balagopal, M.D.

    Department

    Medicine

  • Bryan Lau Lab

    The Bryan Lau Lab is interested in epidemiological and statistical methods for cohort studies and the application of these methods primarily to HIV cohort studies. We’re particularly interested in developing new methods and using approaches from other disciplines as novel solutions to specific epidemiologic issues.

    Research Areas: epidemiology, cohort studies, AIDS, HIV, biostatistics

    Lab Website

    Principal Investigator

    Bryan Lau, Ph.D.

    Department

    Medicine

  • Charles Holmes Lab

    Researchers in the Charles Holmes Lab study large-scale strategies for improving information for public health decision-making and for developing more effective and efficient health care delivery models. This includes working on strategies to expand access to antiretroviral therapies and services aimed at preventing mother-to-child disease transmission, as well as methods to integrate evolving science into public health policy.

    Research Areas: antiretroviral therapies, infectious disease, medical decision making, HIV, public health, tuberculosis

    Principal Investigator

    Charles Holmes, M.D., M.P.H.

    Department

    Medicine

  • Charles W. Flexner Laboratory

    A. Laboratory activities include the use of accelerator mass spectrometry (AMS) techniques to measure intracellular drugs and drugs metabolites. AMS is a highly sensitive method for detecting tracer amounts of radio-labeled molecules in cells, tissues, and body fluids. We have been able to measure intracellular zidovudine triphosphate (the active anabolite of zidovudine) in peripheral blood mononuclear cells from healthy volunteers given small doses of 14C-zidovudine, and have directly compared the sensitivity of AMS to traditional LC/MS methods carried out in our laboratory.

    B. Clinical research activities investigate the clinical pharmacology of new anti-HIV therapies and drug combinations. Specific drug classes studied include HIV reverse transcriptase inhibitors, protease inhibitors, entry inhibitors (selective CCR5 and CXCR4 antagonists), and integrase inhibitors. Scientific objectives of clinical studies include characterization of early drug activity, toxicity, and pharmacok...inetics. Additional objectives are characterization of pathways of drug metabolism, and identification of clinically significant harmful and beneficial drug interactions mediated by hepatic and intestinal cytochrome P450 isoforms. view more

    Research Areas: antiretroviral drugs, infectious disease, HIV protease inhibitors, HIV, drugs, accelerator mass spectrometry

    Principal Investigator

    Charles Flexner, M.D.

    Department

    Medicine

  • Chloe Thio Lab

    Research in the Chloe Thio lab focuses on several areas. First, HBV virology and immunology in HBV monoinfected and HIV-HBV co-infected individuals that will ultimately help develop a cure for HBV. Second, HCV infection in men who have sex with men. Third, non-alcoholic fatty liver disease with a focus on HIV-infected individuals. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance.

    Research Areas: HIV-HBV co-infection, hepatitis B, genomics, hepatitis C, fatty liver

    Principal Investigator

    Chloe Thio, M.D.

    Department

    Medicine

  • Christian Merlo Lab

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failure of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients.

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

    Principal Investigator

    Christian Merlo, M.D., M.P.H.

    Department

    Medicine

  • Christine Durand Lab

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopkins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased ...donor liver transplantation. view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C

    Principal Investigator

    Christine Durand, M.D.

    Department

    Medicine

  • Clinical Laboratory and Biomarkers Core

    The Clinical Laboratory and Biomarkers Cores will coordinate access to laboratory expertise, testing, training, specimen repositories and Good Clinical Laboratory Practices (GCLP). The goals of this core are to assure that all JHU HIV investigators have access to and utilize appropriate, validated and, where applicable, certified laboratory assays. The core will also maintain a biomarker specimen repository for storage cataloguing and utilization of biological specimens.

    Research Areas: virology, immunology, biomarkers, HIV, pathogenesis

    Lab Website

    Principal Investigator

    Craig W. Hendrix, M.D.

    Department

    Medicine

  • Craig W. Hendrix Lab

    Research in the Craig W. Hendrix Lab concentrates on the chemoprevention of HIV infection, clinical pharmacology of antiviral drugs, drug interactions, and oral, topical and injectable HIV microbicide development. Our lab conducts small, intensive sampling studies of PK and PD of drugs for HIV prevention with a focus on developing methods to better understand HIV and drug distribution in the male genital tract, female genital tract and lower gastrointestinal tract. We also support numerous HIV pre-exposure prophylaxis development studies from phase I to phase III, largely as leader of the Pharmacology Core Laboratory of both the Microbicide Trial Network and HIV Prevention Trials Network.

    Research Areas: antiretroviral therapies, infectious disease, HIV, drugs

    Principal Investigator

    Craig W. Hendrix, M.D.

    Department

    Medicine

  • David Celentano Lab

    The David Celentano Lab studies behavioral and social epidemiology by integrating behavioral science theory and research with epidemiology methods. Our team directs epidemiological investigations and stages preventive interventions targeting HIV/AIDS and other sexually transmitted infections.

    Research Areas: epidemiology, opioids, AIDS, HIV, sexually transmitted diseases

    Principal Investigator

    David Celentano, Sc.D.

    Department

    Medicine

  • David Graham Lab

    The David Graham Lab studies the consequences of HIV interactions with the immune system, the resulting pathogenesis and how to sabotage these interactions. We apply advanced technologies like mass spectrometry to dissect processes at the molecular level. We are also actively involved in cardiovascular research and studies the ways proteins are organized into functional units in different cell types of the heart.

    Major projects in our lab are organized into three major areas: (1) H/SIV pathogenesis and neuropathogenesis, (2) Cardiovascular disease, and (3) High technology development

    Research Areas: immunology, mass spectrometry, HIV, cardiovascular, SIV, pathogenesis

    Principal Investigator

    David Graham, M.S., Ph.D.

    Department

    Molecular and Comparative Pathobiology

  • David Holtgrave Lab

    Work in the David Holtgrave Lab primarily assesses the efficacy and cost-effectiveness of HIV prevention and care interventions in an effort to apply our findings to HIV prevention policy making. Our team also conducts research on the intersection of infectious disease rates, risk behavior prevalence and social capital measures. We have also studied the economic effectiveness of smoking interventions.

    Research Areas: smoking cessation, infectious disease, AIDS, HIV, economics, public policy

    Principal Investigator

    David Holtgrave, Ph.D.

    Department

    Medicine
    Oncology

  • David Thomas Lab

    The David Thomas Lab oversees clinical research projects that aim to understand the natural history and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people.

    Research Areas: HIV, hepatitis C, liver diseases

    Principal Investigator

    David Thomas, M.D., M.P.H.

    Department

    Medicine

  • Erica Johnson Lab

    Research in the Erica Johnson Lab investigates infection control in military deployment environments as well as infections that are associated with combat trauma. We explore topics such as HIV outcomes, gender-based health issues and disparities in care.

    Research Areas: gender-based health issues, infectious disease, combat trauma, HIV, deployment infection control, health disparities

    Lab Website

    Principal Investigator

    Erica Johnson, M.D.

    Department

    Medicine

  • Ernesto Freire Laboratory

    The Ernesto Freire Lab studies the use of novel drugs to treat disease. Our research has resulted in the development of a thermodynamic platform for drug discovery and optimization. Our aim is to achieve high binding affinity and selectivity as well as appropriate pharmacokinetics with the platform. We are currently focusing on drug targets such as HIV/-1 protease inhibitors (HIV/AIDS), plasmepsin inhibitors (malaria), HCV protease inhibitors (hepatitis C), coronavirus 3CL-pro protease inhibitors (SARS and other viral infections), HIV-1 gp120 inhibitors (HIV/AIDS), chymase inhibitors (cardiovascular disease) and beta lactamase inhibitors (antibiotic resistance).

    Research Areas: pharmaceuticals, thermodynamics, AIDS, drug discovery, HIV, protease inhibitors, malaria

  • Gail Berkenblit Lab

    The Gail Berkenblit Lab focuses on HIV testing. We are particularly interested in the training of residents as it relates to HIV outpatient care, and the development and assessment of online curriculum.

    Research Areas: medical education, HIV

    Principal Investigator

    Gail Berkenblit, M.D., Ph.D.

    Department

    Medicine

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